CL2018001522A1 - Focalización de péptidos para dirigir virus adenoasociados (aavs) - Google Patents
Focalización de péptidos para dirigir virus adenoasociados (aavs)Info
- Publication number
- CL2018001522A1 CL2018001522A1 CL2018001522A CL2018001522A CL2018001522A1 CL 2018001522 A1 CL2018001522 A1 CL 2018001522A1 CL 2018001522 A CL2018001522 A CL 2018001522A CL 2018001522 A CL2018001522 A CL 2018001522A CL 2018001522 A1 CL2018001522 A1 CL 2018001522A1
- Authority
- CL
- Chile
- Prior art keywords
- aavs
- peptides
- direct
- focalization
- adeno
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2093—Leukaemia inhibitory factor [LIF]
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- A—HUMAN NECESSITIES
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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- A—HUMAN NECESSITIES
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- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
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- A—HUMAN NECESSITIES
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- A61K38/46—Hydrolases (3)
- A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
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- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/015—Parvoviridae, e.g. feline panleukopenia virus, human parvovirus
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/122—Hairpin
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- C12N2310/141—MicroRNAs, miRNAs
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- C12N2320/00—Applications; Uses
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- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14142—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule
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- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
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- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/0102—Alpha-glucosidase (3.2.1.20)
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- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/14—Dipeptidyl-peptidases and tripeptidyl-peptidases (3.4.14)
- C12Y304/14009—Tripeptidyl-peptidase I (3.4.14.9)
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- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
- C12Y305/01015—Aspartoacylase (3.5.1.15)
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Abstract
AQUÍ SE DIVULGAN SECUENCIAS DE PÉPTIDOS CAPACES DE DIRIGIR VIRUS ADENOASOCIADOS (AAV) PARA FOCALIZAR AMBIENTES ESPECÍFICOS, POR EJEMPLO EL SISTEMA NERVIOSO Y EL CORAZÓN, EN UN SUJETO. TAMBIÉN SE DIVULGAN AAVS QUE TIENEN PROTEÍNAS DE LA CÁPSIDE QUE NO OCURREN NATURALMENTE COMPRENDIENDO LAS SECUENCIAS DE PÉPTIDOS DIVULGADAS, Y MÉTODOS PARA UTILIZAR LOS AAVS PARA TRATAR ENFERMEDADES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562266184P | 2015-12-11 | 2015-12-11 | |
US201662421891P | 2016-11-14 | 2016-11-14 |
Publications (1)
Publication Number | Publication Date |
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CL2018001522A1 true CL2018001522A1 (es) | 2018-12-21 |
Family
ID=59013356
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2018001522A CL2018001522A1 (es) | 2015-12-11 | 2018-06-07 | Focalización de péptidos para dirigir virus adenoasociados (aavs) |
Country Status (19)
Country | Link |
---|---|
US (2) | US11499165B2 (es) |
EP (2) | EP3387137B1 (es) |
JP (1) | JP7066619B2 (es) |
KR (1) | KR102423442B1 (es) |
CN (1) | CN108699565B (es) |
AU (1) | AU2016366549B2 (es) |
BR (1) | BR112018011711A2 (es) |
CA (1) | CA3007495C (es) |
CL (1) | CL2018001522A1 (es) |
CO (1) | CO2018007203A2 (es) |
DK (1) | DK3387137T3 (es) |
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GB201403684D0 (en) * | 2014-03-03 | 2014-04-16 | King S College London | Vector |
HUE054768T2 (hu) | 2014-05-02 | 2021-09-28 | Genzyme Corp | AAV vektorok retina és CNS génterápiára |
WO2017100671A1 (en) | 2015-12-11 | 2017-06-15 | California Institute Of Technology | TARGETING PEPTIDES FOR DIRECTING ADENO-ASSOCIATED VIRUSES (AAVs) |
WO2018204786A1 (en) | 2017-05-05 | 2018-11-08 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
WO2018204797A1 (en) | 2017-05-05 | 2018-11-08 | Voyager Therapeutics, Inc. | Modulatory polynucleotides |
WO2018204803A1 (en) | 2017-05-05 | 2018-11-08 | Voyager Therapeutics, Inc. | Compositions and methods of treating huntington's disease |
EP3662060A2 (en) | 2017-08-03 | 2020-06-10 | Voyager Therapeutics, Inc. | Compositions and methods for delivery of aav |
-
2016
- 2016-12-09 WO PCT/US2016/065969 patent/WO2017100671A1/en active Application Filing
- 2016-12-09 RU RU2018120736A patent/RU2727672C2/ru active
- 2016-12-09 US US15/374,596 patent/US11499165B2/en active Active
- 2016-12-09 EP EP16873985.2A patent/EP3387137B1/en active Active
- 2016-12-09 CN CN201680081708.1A patent/CN108699565B/zh active Active
- 2016-12-09 CO CONC2018/0007203A patent/CO2018007203A2/es unknown
- 2016-12-09 KR KR1020187019747A patent/KR102423442B1/ko active IP Right Grant
- 2016-12-09 JP JP2018530606A patent/JP7066619B2/ja active Active
- 2016-12-09 CA CA3007495A patent/CA3007495C/en active Active
- 2016-12-09 EP EP21152352.7A patent/EP3875593A1/en active Pending
- 2016-12-09 BR BR112018011711A patent/BR112018011711A2/pt active Search and Examination
- 2016-12-09 MX MX2018006840A patent/MX2018006840A/es unknown
- 2016-12-09 SG SG11201804713VA patent/SG11201804713VA/en unknown
- 2016-12-09 ES ES16873985T patent/ES2869284T3/es active Active
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2018
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- 2018-06-07 ZA ZA201803808A patent/ZA201803808B/en unknown
- 2018-12-27 HK HK18116620.4A patent/HK1257563A1/zh unknown
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2022
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AU2016366549A1 (en) | 2018-07-12 |
KR102423442B1 (ko) | 2022-07-20 |
AU2016366549B2 (en) | 2022-11-10 |
DK3387137T3 (da) | 2021-05-03 |
CN108699565B (zh) | 2023-08-08 |
JP2019506141A (ja) | 2019-03-07 |
CA3007495C (en) | 2023-04-11 |
HK1257563A1 (zh) | 2019-10-25 |
EP3387137B1 (en) | 2021-02-03 |
EP3387137A4 (en) | 2019-06-12 |
WO2017100671A1 (en) | 2017-06-15 |
CO2018007203A2 (es) | 2018-09-20 |
US20230295659A1 (en) | 2023-09-21 |
MX2018006840A (es) | 2019-03-28 |
EP3875593A1 (en) | 2021-09-08 |
ZA201803808B (en) | 2020-11-25 |
BR112018011711A2 (pt) | 2018-12-04 |
ES2869284T3 (es) | 2021-10-25 |
EP3387137A1 (en) | 2018-10-17 |
KR20180097629A (ko) | 2018-08-31 |
US11499165B2 (en) | 2022-11-15 |
RU2018120736A3 (es) | 2020-01-13 |
JP7066619B2 (ja) | 2022-05-13 |
RU2727672C2 (ru) | 2020-07-22 |
CA3007495A1 (en) | 2017-06-15 |
IL259842A (en) | 2018-07-31 |
RU2018120736A (ru) | 2020-01-13 |
US20170166926A1 (en) | 2017-06-15 |
IL259842B (en) | 2022-08-01 |
CN108699565A (zh) | 2018-10-23 |
SG11201804713VA (en) | 2018-07-30 |
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