CL2017002709A1 - Compuestos de pirazolo - y triazolo - pirimidina antivirales contra vsr - Google Patents

Compuestos de pirazolo - y triazolo - pirimidina antivirales contra vsr

Info

Publication number
CL2017002709A1
CL2017002709A1 CL2017002709A CL2017002709A CL2017002709A1 CL 2017002709 A1 CL2017002709 A1 CL 2017002709A1 CL 2017002709 A CL2017002709 A CL 2017002709A CL 2017002709 A CL2017002709 A CL 2017002709A CL 2017002709 A1 CL2017002709 A1 CL 2017002709A1
Authority
CL
Chile
Prior art keywords
compounds
triazolo
pyrazolo
vsr
pyrimidine
Prior art date
Application number
CL2017002709A
Other languages
English (en)
Inventor
Pierre Jean-Marie Bernard Raboisson
David Francis Alain Lançois
Jérôme Émile Georges Guillemont
Dirk André Emmy Roymans
Boris Rogovoy
Vadim Bichko
Delphine Yvonne Raymonde Lardeau
Antoine Benjamin Michaut
Anil Koul
Original Assignee
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc
Publication of CL2017002709A1 publication Critical patent/CL2017002709A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

<p>La invención se refiere a compuestos de pirazolo- y triazolo-pirimidina sustituidos novedosos de fórmula (I) que tienen actividad antiviral, en particular, que tienen una actividad inhibidora sobre la replicación del virus sincitial respiratorio (VSR). La invención se refiere además a composiciones farmacéuticas que comprenden estos compuestos y a los compuestos para su uso en el tratamiento de la infección por el virus sincitial respiratorio.</p>
CL2017002709A 2015-04-28 2017-10-25 Compuestos de pirazolo - y triazolo - pirimidina antivirales contra vsr CL2017002709A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562153753P 2015-04-28 2015-04-28
US201562204390P 2015-08-12 2015-08-12

Publications (1)

Publication Number Publication Date
CL2017002709A1 true CL2017002709A1 (es) 2018-04-20

Family

ID=55860847

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017002709A CL2017002709A1 (es) 2015-04-28 2017-10-25 Compuestos de pirazolo - y triazolo - pirimidina antivirales contra vsr

Country Status (30)

Country Link
US (3) US10208048B2 (es)
EP (1) EP3288942B1 (es)
JP (1) JP6698693B2 (es)
KR (1) KR102538565B1 (es)
CN (1) CN107531715B (es)
AU (1) AU2016254700B2 (es)
BR (1) BR112017023263B1 (es)
CA (1) CA2981404C (es)
CL (1) CL2017002709A1 (es)
CY (1) CY1125329T1 (es)
DK (1) DK3288942T3 (es)
EA (1) EA035689B1 (es)
ES (1) ES2905550T3 (es)
HK (1) HK1248230A1 (es)
HR (1) HRP20211728T1 (es)
HU (1) HUE057626T2 (es)
IL (1) IL254750B (es)
JO (1) JO3637B1 (es)
LT (1) LT3288942T (es)
MA (1) MA41974A (es)
MX (1) MX369040B (es)
PH (1) PH12017501958A1 (es)
PL (1) PL3288942T3 (es)
PT (1) PT3288942T (es)
SG (1) SG11201708786SA (es)
SI (1) SI3288942T1 (es)
TW (1) TWI703146B (es)
UA (1) UA120448C2 (es)
WO (1) WO2016174079A1 (es)
ZA (1) ZA201707320B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3637B1 (ar) 2015-04-28 2020-08-27 Janssen Sciences Ireland Uc مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv
TW201932470A (zh) * 2017-11-29 2019-08-16 愛爾蘭商健生科學愛爾蘭無限公司 具有抗ｒｓｖ活性之吡唑并嘧啶
TW201936193A (zh) * 2017-12-05 2019-09-16 愛爾蘭商健生科學愛爾蘭無限公司 使用組合產品治療ｒｓｖ
JP7305658B2 (ja) * 2018-01-31 2023-07-10 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー 抗ｒｓｖ活性を有するシクロアルキル置換ピラゾロピリミジン
WO2019206828A1 (en) 2018-04-23 2019-10-31 Janssen Sciences Ireland Unlimited Company Heteroaromatic compounds having activity against rsv
WO2019213579A1 (en) * 2018-05-03 2019-11-07 Georgia State University Research Foundation, Inc. Inhibitors of rsv replication and applications thereof
MX2021006138A (es) * 2018-11-26 2021-06-23 Janssen Sciences Ireland Unlimited Co Otros compuestos heteroaromaticos que tienen actividad contra el vrs.
WO2020138015A1 (ja) 2018-12-27 2020-07-02 大正製薬株式会社 ピラゾロ［１，５－ａ］ピリミジン大環状化合物
KR20220011634A (ko) 2019-05-23 2022-01-28 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 Rsv에 대한 활성을 갖는 기타 헤테로방향족 화합물
CN111440173B (zh) * 2020-03-27 2021-05-14 山东大学 一种pi3k抑制剂的制备方法
WO2022020889A1 (en) * 2020-07-27 2022-02-03 Esfam Biotech Pty Ltd Method of treatment of cytomegalovirus
WO2022020891A1 (en) * 2020-07-27 2022-02-03 Esfam Biotech Pty Ltd Methods of prophylaxis and treatment of corona virus
CN116425754A (zh) * 2021-12-30 2023-07-14 苏州爱科百发生物医药技术有限公司 芳杂双环化合物及其抗病毒用途
WO2023245166A2 (en) * 2022-06-17 2023-12-21 Trawsfynydd Therapeutics, Inc. Compounds for treatment of a coronavirus infection
WO2024121262A1 (en) 2022-12-09 2024-06-13 Syngenta Crop Protection Ag Insecticidal compound based on pyrazole derivatives
WO2024121264A1 (en) 2022-12-09 2024-06-13 Syngenta Crop Protection Ag Insecticidal compound based on pyrazole derivatives
WO2024121261A1 (en) 2022-12-09 2024-06-13 Syngenta Crop Protection Ag Insecticidal compound based on pyrazole derivatives
WO2024121263A1 (en) 2022-12-09 2024-06-13 Syngenta Crop Protection Ag Insecticidal compound based on pyrazole derivatives

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4250596A (en) 1994-12-22 1996-07-10 Biochem Pharma Inc. Low molecular weight bicyclic thrombin inhibitors
JP2000501063A (ja) 1995-06-29 2000-02-02 メルク エンド カンパニー インコーポレーテッド ファルネシル−タンパク質トランスフェラーゼ阻害剤の組み合わせ
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
US5972966A (en) 1996-12-05 1999-10-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5977134A (en) 1996-12-05 1999-11-02 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6177443B1 (en) 1997-03-07 2001-01-23 Novo Nordisk A/S 4,5,6,7-tetrahydro-thieno[3, 2-C]pyridine derivatives, their preparation and use
WO2001005768A1 (fr) 1999-07-19 2001-01-25 Shionogi & Co., Ltd. Composes tricycliques porteurs de pendants acyloxymethoxycarbonyle
EP1113007A1 (en) 1999-12-24 2001-07-04 Pfizer Inc. Tetrahydroisoquinoline compounds as estrogen agonists/antagonists
US20030073681A1 (en) 2001-08-21 2003-04-17 Hauske James R. 2-substituted piperidines that are ligands for monoamine receptors and transporters
MXPA04010441A (es) 2002-04-23 2005-02-14 Shionogi & Co Derivado de pirazolo[1,5-a]pirimidina e inhibidor de nad(p)h oxidasa que contiene el mismo.
JP4469720B2 (ja) 2002-09-20 2010-05-26 メディシン テクノロジーズ インコーポレーテッド 治療薬及び対応する治療
AU2003260908A1 (en) 2002-09-26 2004-04-19 Pfizer Inc. Pyrazole derivatives as reverse transcriptase inhibitors
WO2004037817A1 (ja) 2002-10-25 2004-05-06 Mitsubishi Pharma Corporation Ｎ−オキシド化合物
AR043633A1 (es) 2003-03-20 2005-08-03 Schering Corp Ligandos de receptores de canabinoides
CA2520124A1 (en) 2003-03-28 2004-10-14 Chiron Corporation Use of benzazole compounds for immunopotentiation
FR2856596B1 (fr) 2003-06-27 2007-04-27 Bioprojet Soc Civ Nouvelle association medicamenteuse psychiatrique et utilisation d'une antagoniste ou agoniste inverse du recepteur h3 de l'histamine pour preparer un medicament prevenant des effets indesirables de psychotropes.
EP1671962A1 (en) 2003-10-10 2006-06-21 Ono Pharmaceutical Co., Ltd. Novel fused heterocyclic compound and use thereof
US7323567B2 (en) 2003-10-30 2008-01-29 Boehringer Ingelheim (Canada) Ltd. RSV polymerase inhibitors
AR046959A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
EP1697377B1 (en) 2003-12-24 2011-01-26 Biota Scientific Management Pty. Ltd. Polycyclic agents for the treatment of respiratory syncytial virus infections
NZ553696A (en) 2004-09-13 2010-02-26 Ono Pharmaceutical Co Nitrogenous heterocyclic derivative and medicine containing the same as an active ingredient
AU2005286731A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase
WO2007044085A2 (en) 2005-05-19 2007-04-19 Xenon Pharmaceuticals Inc. Heteroaryl compounds and their uses as therapeutic agents
AU2006260969B2 (en) * 2005-06-20 2011-11-17 Janssen Sciences Ireland Uc 1- ( 2-amino-3- (substituted alkyl)-3H-benzimidazolylmethyl) -3-substituted-1,3-dihydro-benzoimidazol-2-ones with activity on respiratory syncytial virus
US7507842B2 (en) 2005-08-12 2009-03-24 Radiorx, Inc. Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof
CN101360736A (zh) 2005-11-23 2009-02-04 阿斯利康(瑞典)有限公司 L-丙氨酸衍生物
JP2009544625A (ja) * 2006-07-20 2009-12-17 メーメット・カーラマン Ｒｈｏキナーゼのベンゾチオフェン阻害剤
EP2102211A2 (en) 2006-11-20 2009-09-23 Alantos Pharmaceuticals Holding, Inc. Heterobicyclic metalloprotease inhibitors
AU2008287421A1 (en) 2007-08-10 2009-02-19 Glaxosmithkline Llc Nitrogen containing bicyclic chemical entities for treating viral infections
JP2011506335A (ja) 2007-12-06 2011-03-03 シェーリング コーポレイション γ−セクレターゼ調節剤
CN102186479A (zh) 2008-09-10 2011-09-14 凯利普西斯公司 用于治疗疾病的组胺受体的氨基嘧啶抑制剂
TW201022266A (en) 2008-10-23 2010-06-16 Boehringer Ingelheim Int Urea derivatives of substituted nortropanes, medicaments containing such compounds and their use
US20100204265A1 (en) 2009-02-09 2010-08-12 Genelabs Technologies, Inc. Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections
KR20100101054A (ko) 2009-03-07 2010-09-16 주식회사 메디젠텍 세포핵에서 세포질로의 ｇｓｋ３의 이동을 억제하는 화합물을 함유하는 세포핵에서 세포질로의 ｇｓｋ３ 이동에 의해 발생되는 질환의 치료 또는 예방용 약학적 조성물
EP2410857B1 (en) 2009-03-23 2014-01-29 Merck Sharp & Dohme Corp. P2x3, receptor antagonists for treatment of pain
US8937150B2 (en) 2009-06-11 2015-01-20 Abbvie Inc. Anti-viral compounds
RS52854B (en) 2009-06-11 2013-12-31 Abbvie Bahamas Limited INHIBITOR OF PATITIS C VIRUSA
SG10201505022WA (en) * 2010-06-24 2015-07-30 Gilead Sciences Inc Pyrazolo [1, 5 -a] pyrimidines as antiviral agents
CA2825098C (en) * 2011-01-27 2020-03-10 Universite De Montreal Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators
DK2838900T3 (da) * 2012-04-17 2019-10-14 Gilead Sciences Inc Forbindelser og fremgangsmåder til antiviral behandling
TWI652014B (zh) * 2013-09-13 2019-03-01 美商艾佛艾姆希公司 雜環取代之雙環唑殺蟲劑
JP6564380B2 (ja) 2013-09-20 2019-08-21 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 前立腺癌を治療するための化合物
CA2935944A1 (en) 2014-01-09 2015-07-16 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Substituted benzoxazine and related compounds
KR101551313B1 (ko) 2014-07-28 2015-09-09 충남대학교산학협력단 신규한 인덴 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 망막 질환의 예방 또는 치료용 약학적 조성물
AU2015341913B2 (en) 2014-11-03 2020-07-16 Iomet Pharma Ltd Pharmaceutical compound
WO2016091774A1 (en) 2014-12-08 2016-06-16 Janssen Sciences Ireland Uc Piperidine substituted pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (rsv)
CN105777632A (zh) 2015-01-09 2016-07-20 成都贝斯凯瑞生物科技有限公司 芳环并氮杂环衍生物及其应用
JO3637B1 (ar) * 2015-04-28 2020-08-27 Janssen Sciences Ireland Uc مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv

Also Published As

Publication number Publication date
PH12017501958B1 (en) 2018-03-26
IL254750A0 (en) 2017-11-30
AU2016254700A1 (en) 2017-10-19
CN107531715A (zh) 2018-01-02
US20200223855A1 (en) 2020-07-16
IL254750B (en) 2020-07-30
AU2016254700B2 (en) 2020-01-02
MA41974A (fr) 2018-03-07
HUE057626T2 (hu) 2022-05-28
EA035689B1 (ru) 2020-07-27
US10208048B2 (en) 2019-02-19
HK1248230A1 (zh) 2018-10-12
DK3288942T3 (da) 2022-01-17
JO3637B1 (ar) 2020-08-27
BR112017023263B1 (pt) 2023-04-11
ES2905550T3 (es) 2022-04-11
CA2981404C (en) 2023-09-19
EP3288942A1 (en) 2018-03-07
UA120448C2 (uk) 2019-12-10
EA201792370A1 (ru) 2018-02-28
US11084826B2 (en) 2021-08-10
SI3288942T1 (sl) 2022-01-31
JP2018514544A (ja) 2018-06-07
TWI703146B (zh) 2020-09-01
PT3288942T (pt) 2021-12-17
US20190248793A1 (en) 2019-08-15
TW201708227A (zh) 2017-03-01
HRP20211728T1 (hr) 2022-02-18
US20180105529A1 (en) 2018-04-19
EP3288942B1 (en) 2021-10-27
KR20170139122A (ko) 2017-12-18
SG11201708786SA (en) 2017-11-29
JP6698693B2 (ja) 2020-05-27
PL3288942T3 (pl) 2022-02-21
BR112017023263A2 (pt) 2018-08-07
MX2017013884A (es) 2018-03-16
LT3288942T (lt) 2021-12-10
US10611769B2 (en) 2020-04-07
MX369040B (es) 2019-10-25
CN107531715B (zh) 2021-03-30
WO2016174079A1 (en) 2016-11-03
PH12017501958A1 (en) 2018-03-26
KR102538565B1 (ko) 2023-05-30
ZA201707320B (en) 2020-08-26
CY1125329T1 (el) 2024-02-16
CA2981404A1 (en) 2016-11-03

Similar Documents

Publication Publication Date Title
CL2017002709A1 (es) Compuestos de pirazolo - y triazolo - pirimidina antivirales contra vsr
CL2017000379A1 (es) Compuestos de pirrolopirimidina usados como agonistas del receptor de tipo toll. 7 (tlr7)
BR112017013491A2 (pt) compostos de pirimidina fundida para o tratamento de hiv
SV2018005750A (es) Derivados de compuestos de indol sustituidos como inhibidores de la replicacion virica del dengue
GT201700234A (es) Derivados de indol mono o disustituidos como inhibidores de la replicación viral del dengue
NZ733174A (en) Quinazoline derivatives used to treat hiv
UY37645A (es) Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
CL2016000381A1 (es) Compuestos antivirales
ECSP11011310A (es) Análogos carba - nucleósido para tratamiento antiviral
CO2018008421A2 (es) Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
CL2017001923A1 (es) Derivados de 9h-pirrolo-dipiridina
PE20151867A1 (es) Polipeptidos f de prefusion del virus sincicial respiratorio (rsv )solubles y estabilizados
UY37741A (es) Derivados de indolina sustituidos como inhibidores de la replicación del virus del dengue
UY37646A (es) Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
CL2014000311A1 (es) Compuestos derivados de benzotiazepinas sustituidas; composicion farmaceutica que los contiene; y su uso para el tratamiento o profilaxis de la infeccion del virus sincicial respiratorio.
CO2018009563A2 (es) Derivados de indolina sustituidos como inhibidores de la replicación viral del dengue
BR112017013440A2 (pt) compostos de isoquinolina para o tratamento de hiv
CU20170109A7 (es) Derivado de quinoleina para tratar y prevenir infecciones virales
CL2016001973A1 (es) Derivados de nucleosido sustituidos con 4&#39; -difluorometilo como inhibidores de la replicación de arn de la influenza.
CO2018007669A2 (es) Pirimidinas sustituidas con arilo para su uso en la infección por virus influenza
EA201690687A1 (ru) Ингибиторы репликации вируса иммунодефицита
BR112017003242A2 (pt) composto, métodos para tratar infecção por vírus e para fabricação de um medicamento, composição farmacêutica, e, uso de um composto.
CU24519B1 (es) Derivados de aminotiazol útiles como agentes antivíricos
UY36145A (es) Compuestos de 1, 3, 4-tiadiazol y uso de los mismos para el tratamiento del cáncer
EA201790495A1 (ru) Фармацевтические композиции длительного действия