DK3288942T3 - Rsv-antivirale pyrazolo- og triazolopyrimidinforbindelser - Google Patents

Rsv-antivirale pyrazolo- og triazolopyrimidinforbindelser Download PDF

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Publication number
DK3288942T3
DK3288942T3 DK16719387.9T DK16719387T DK3288942T3 DK 3288942 T3 DK3288942 T3 DK 3288942T3 DK 16719387 T DK16719387 T DK 16719387T DK 3288942 T3 DK3288942 T3 DK 3288942T3
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Denmark
Prior art keywords
pyrazolo
triazolopyrimidine compounds
rsv antiviral
rsv
antiviral
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DK16719387.9T
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English (en)
Inventor
David Francis Alain Lançois
Jérôme Émile Georges Guillemont
Pierre Jean-Marie Bernard Raboisson
Dirk André Emmy Roymans
Boris Rogovoy
Vadim Bichko
Delphine Yvonne Raymonde Lardeau
Antoine Benjamin Michaut
Anil Koul
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Janssen Sciences Ireland Unlimited Co
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Publication of DK3288942T3 publication Critical patent/DK3288942T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK16719387.9T 2015-04-28 2016-04-27 Rsv-antivirale pyrazolo- og triazolopyrimidinforbindelser DK3288942T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562153753P 2015-04-28 2015-04-28
US201562204390P 2015-08-12 2015-08-12
PCT/EP2016/059392 WO2016174079A1 (en) 2015-04-28 2016-04-27 Rsv antiviral pyrazolo- and triazolo-pyrimidine compounds

Publications (1)

Publication Number Publication Date
DK3288942T3 true DK3288942T3 (da) 2022-01-17

Family

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DK16719387.9T DK3288942T3 (da) 2015-04-28 2016-04-27 Rsv-antivirale pyrazolo- og triazolopyrimidinforbindelser

Country Status (30)

Country Link
US (3) US10208048B2 (da)
EP (1) EP3288942B1 (da)
JP (1) JP6698693B2 (da)
KR (1) KR102538565B1 (da)
CN (1) CN107531715B (da)
AU (1) AU2016254700B2 (da)
BR (1) BR112017023263B1 (da)
CA (1) CA2981404C (da)
CL (1) CL2017002709A1 (da)
CY (1) CY1125329T1 (da)
DK (1) DK3288942T3 (da)
EA (1) EA035689B1 (da)
ES (1) ES2905550T3 (da)
HK (1) HK1248230A1 (da)
HR (1) HRP20211728T1 (da)
HU (1) HUE057626T2 (da)
IL (1) IL254750B (da)
JO (1) JO3637B1 (da)
LT (1) LT3288942T (da)
MA (1) MA41974A (da)
MX (1) MX369040B (da)
PH (1) PH12017501958A1 (da)
PL (1) PL3288942T3 (da)
PT (1) PT3288942T (da)
SG (1) SG11201708786SA (da)
SI (1) SI3288942T1 (da)
TW (1) TWI703146B (da)
UA (1) UA120448C2 (da)
WO (1) WO2016174079A1 (da)
ZA (1) ZA201707320B (da)

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Also Published As

Publication number Publication date
BR112017023263B1 (pt) 2023-04-11
HK1248230A1 (zh) 2018-10-12
US20180105529A1 (en) 2018-04-19
CN107531715A (zh) 2018-01-02
AU2016254700B2 (en) 2020-01-02
MX2017013884A (es) 2018-03-16
PT3288942T (pt) 2021-12-17
US20200223855A1 (en) 2020-07-16
LT3288942T (lt) 2021-12-10
EA201792370A1 (ru) 2018-02-28
JP6698693B2 (ja) 2020-05-27
JP2018514544A (ja) 2018-06-07
TW201708227A (zh) 2017-03-01
CA2981404A1 (en) 2016-11-03
CY1125329T1 (el) 2024-02-16
EP3288942A1 (en) 2018-03-07
PH12017501958B1 (en) 2018-03-26
KR20170139122A (ko) 2017-12-18
ZA201707320B (en) 2020-08-26
MA41974A (fr) 2018-03-07
ES2905550T3 (es) 2022-04-11
UA120448C2 (uk) 2019-12-10
HRP20211728T1 (hr) 2022-02-18
AU2016254700A1 (en) 2017-10-19
IL254750A0 (en) 2017-11-30
US20190248793A1 (en) 2019-08-15
EP3288942B1 (en) 2021-10-27
EA035689B1 (ru) 2020-07-27
CA2981404C (en) 2023-09-19
JO3637B1 (ar) 2020-08-27
MX369040B (es) 2019-10-25
KR102538565B1 (ko) 2023-05-30
CL2017002709A1 (es) 2018-04-20
TWI703146B (zh) 2020-09-01
IL254750B (en) 2020-07-30
WO2016174079A1 (en) 2016-11-03
SG11201708786SA (en) 2017-11-29
SI3288942T1 (sl) 2022-01-31
US10208048B2 (en) 2019-02-19
US11084826B2 (en) 2021-08-10
BR112017023263A2 (pt) 2018-08-07
CN107531715B (zh) 2021-03-30
HUE057626T2 (hu) 2022-05-28
PL3288942T3 (pl) 2022-02-21
PH12017501958A1 (en) 2018-03-26
US10611769B2 (en) 2020-04-07

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