DK3288942T3 - Rsv-antivirale pyrazolo- og triazolopyrimidinforbindelser - Google Patents
Rsv-antivirale pyrazolo- og triazolopyrimidinforbindelser Download PDFInfo
- Publication number
- DK3288942T3 DK3288942T3 DK16719387.9T DK16719387T DK3288942T3 DK 3288942 T3 DK3288942 T3 DK 3288942T3 DK 16719387 T DK16719387 T DK 16719387T DK 3288942 T3 DK3288942 T3 DK 3288942T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyrazolo
- triazolopyrimidine compounds
- rsv antiviral
- rsv
- antiviral
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562153753P | 2015-04-28 | 2015-04-28 | |
US201562204390P | 2015-08-12 | 2015-08-12 | |
PCT/EP2016/059392 WO2016174079A1 (en) | 2015-04-28 | 2016-04-27 | Rsv antiviral pyrazolo- and triazolo-pyrimidine compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3288942T3 true DK3288942T3 (da) | 2022-01-17 |
Family
ID=55860847
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK16719387.9T DK3288942T3 (da) | 2015-04-28 | 2016-04-27 | Rsv-antivirale pyrazolo- og triazolopyrimidinforbindelser |
Country Status (30)
Country | Link |
---|---|
US (3) | US10208048B2 (da) |
EP (1) | EP3288942B1 (da) |
JP (1) | JP6698693B2 (da) |
KR (1) | KR102538565B1 (da) |
CN (1) | CN107531715B (da) |
AU (1) | AU2016254700B2 (da) |
BR (1) | BR112017023263B1 (da) |
CA (1) | CA2981404C (da) |
CL (1) | CL2017002709A1 (da) |
CY (1) | CY1125329T1 (da) |
DK (1) | DK3288942T3 (da) |
EA (1) | EA035689B1 (da) |
ES (1) | ES2905550T3 (da) |
HK (1) | HK1248230A1 (da) |
HR (1) | HRP20211728T1 (da) |
HU (1) | HUE057626T2 (da) |
IL (1) | IL254750B (da) |
JO (1) | JO3637B1 (da) |
LT (1) | LT3288942T (da) |
MA (1) | MA41974A (da) |
MX (1) | MX369040B (da) |
PH (1) | PH12017501958A1 (da) |
PL (1) | PL3288942T3 (da) |
PT (1) | PT3288942T (da) |
SG (1) | SG11201708786SA (da) |
SI (1) | SI3288942T1 (da) |
TW (1) | TWI703146B (da) |
UA (1) | UA120448C2 (da) |
WO (1) | WO2016174079A1 (da) |
ZA (1) | ZA201707320B (da) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO3637B1 (ar) | 2015-04-28 | 2020-08-27 | Janssen Sciences Ireland Uc | مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv |
TW201932470A (zh) * | 2017-11-29 | 2019-08-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 具有抗rsv活性之吡唑并嘧啶 |
TW201936193A (zh) * | 2017-12-05 | 2019-09-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 使用組合產品治療rsv |
JP7305658B2 (ja) * | 2018-01-31 | 2023-07-10 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | 抗rsv活性を有するシクロアルキル置換ピラゾロピリミジン |
WO2019206828A1 (en) | 2018-04-23 | 2019-10-31 | Janssen Sciences Ireland Unlimited Company | Heteroaromatic compounds having activity against rsv |
WO2019213579A1 (en) * | 2018-05-03 | 2019-11-07 | Georgia State University Research Foundation, Inc. | Inhibitors of rsv replication and applications thereof |
MX2021006138A (es) * | 2018-11-26 | 2021-06-23 | Janssen Sciences Ireland Unlimited Co | Otros compuestos heteroaromaticos que tienen actividad contra el vrs. |
WO2020138015A1 (ja) | 2018-12-27 | 2020-07-02 | 大正製薬株式会社 | ピラゾロ[1,5-a]ピリミジン大環状化合物 |
KR20220011634A (ko) | 2019-05-23 | 2022-01-28 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | Rsv에 대한 활성을 갖는 기타 헤테로방향족 화합물 |
CN111440173B (zh) * | 2020-03-27 | 2021-05-14 | 山东大学 | 一种pi3k抑制剂的制备方法 |
WO2022020889A1 (en) * | 2020-07-27 | 2022-02-03 | Esfam Biotech Pty Ltd | Method of treatment of cytomegalovirus |
WO2022020891A1 (en) * | 2020-07-27 | 2022-02-03 | Esfam Biotech Pty Ltd | Methods of prophylaxis and treatment of corona virus |
CN116425754A (zh) * | 2021-12-30 | 2023-07-14 | 苏州爱科百发生物医药技术有限公司 | 芳杂双环化合物及其抗病毒用途 |
WO2023245166A2 (en) * | 2022-06-17 | 2023-12-21 | Trawsfynydd Therapeutics, Inc. | Compounds for treatment of a coronavirus infection |
WO2024121262A1 (en) | 2022-12-09 | 2024-06-13 | Syngenta Crop Protection Ag | Insecticidal compound based on pyrazole derivatives |
WO2024121264A1 (en) | 2022-12-09 | 2024-06-13 | Syngenta Crop Protection Ag | Insecticidal compound based on pyrazole derivatives |
WO2024121261A1 (en) | 2022-12-09 | 2024-06-13 | Syngenta Crop Protection Ag | Insecticidal compound based on pyrazole derivatives |
WO2024121263A1 (en) | 2022-12-09 | 2024-06-13 | Syngenta Crop Protection Ag | Insecticidal compound based on pyrazole derivatives |
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ZA9610738B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | Subtype selective nmda receptor ligands and the use thereof |
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EP1113007A1 (en) | 1999-12-24 | 2001-07-04 | Pfizer Inc. | Tetrahydroisoquinoline compounds as estrogen agonists/antagonists |
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JO3637B1 (ar) * | 2015-04-28 | 2020-08-27 | Janssen Sciences Ireland Uc | مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv |
-
2016
- 2016-04-25 JO JOP/2016/0080A patent/JO3637B1/ar active
- 2016-04-26 TW TW105112899A patent/TWI703146B/zh not_active IP Right Cessation
- 2016-04-27 HU HUE16719387A patent/HUE057626T2/hu unknown
- 2016-04-27 LT LTEPPCT/EP2016/059392T patent/LT3288942T/lt unknown
- 2016-04-27 PL PL16719387T patent/PL3288942T3/pl unknown
- 2016-04-27 UA UAA201711550A patent/UA120448C2/uk unknown
- 2016-04-27 MA MA041974A patent/MA41974A/fr unknown
- 2016-04-27 PT PT167193879T patent/PT3288942T/pt unknown
- 2016-04-27 AU AU2016254700A patent/AU2016254700B2/en active Active
- 2016-04-27 HR HRP20211728TT patent/HRP20211728T1/hr unknown
- 2016-04-27 WO PCT/EP2016/059392 patent/WO2016174079A1/en active Application Filing
- 2016-04-27 SG SG11201708786SA patent/SG11201708786SA/en unknown
- 2016-04-27 EP EP16719387.9A patent/EP3288942B1/en active Active
- 2016-04-27 EA EA201792370A patent/EA035689B1/ru unknown
- 2016-04-27 CA CA2981404A patent/CA2981404C/en active Active
- 2016-04-27 KR KR1020177033587A patent/KR102538565B1/ko active IP Right Grant
- 2016-04-27 MX MX2017013884A patent/MX369040B/es active IP Right Grant
- 2016-04-27 DK DK16719387.9T patent/DK3288942T3/da active
- 2016-04-27 JP JP2017556537A patent/JP6698693B2/ja active Active
- 2016-04-27 CN CN201680024585.8A patent/CN107531715B/zh active Active
- 2016-04-27 BR BR112017023263-4A patent/BR112017023263B1/pt active IP Right Grant
- 2016-04-27 US US15/570,054 patent/US10208048B2/en active Active
- 2016-04-27 SI SI201631398T patent/SI3288942T1/sl unknown
- 2016-04-27 ES ES16719387T patent/ES2905550T3/es active Active
-
2017
- 2017-09-27 IL IL254750A patent/IL254750B/en active IP Right Grant
- 2017-10-25 CL CL2017002709A patent/CL2017002709A1/es unknown
- 2017-10-26 PH PH12017501958A patent/PH12017501958A1/en unknown
- 2017-10-27 ZA ZA2017/07320A patent/ZA201707320B/en unknown
-
2018
- 2018-06-15 HK HK18107771.0A patent/HK1248230A1/zh unknown
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2019
- 2019-02-11 US US16/272,934 patent/US10611769B2/en active Active
-
2020
- 2020-03-30 US US16/835,073 patent/US11084826B2/en active Active
-
2022
- 2022-01-25 CY CY20221100055T patent/CY1125329T1/el unknown
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