CL2014002726A1 - Compuestos derivados de pirrolopirimidina y purina; composicion farmaceutica; utiles en el tratamiento del cancer (div. sol. 566-14). - Google Patents
Compuestos derivados de pirrolopirimidina y purina; composicion farmaceutica; utiles en el tratamiento del cancer (div. sol. 566-14).Info
- Publication number
- CL2014002726A1 CL2014002726A1 CL2014002726A CL2014002726A CL2014002726A1 CL 2014002726 A1 CL2014002726 A1 CL 2014002726A1 CL 2014002726 A CL2014002726 A CL 2014002726A CL 2014002726 A CL2014002726 A CL 2014002726A CL 2014002726 A1 CL2014002726 A1 CL 2014002726A1
- Authority
- CL
- Chile
- Prior art keywords
- pyrrolopyrimidine
- div
- purine
- sol
- cancer
- Prior art date
Links
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 title 2
- KDOPAZIWBAHVJB-UHFFFAOYSA-N 5h-pyrrolo[3,2-d]pyrimidine Chemical compound C1=NC=C2NC=CC2=N1 KDOPAZIWBAHVJB-UHFFFAOYSA-N 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161538103P | 2011-09-22 | 2011-09-22 | |
| US201261639639P | 2012-04-27 | 2012-04-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014002726A1 true CL2014002726A1 (es) | 2015-02-13 |
Family
ID=47116127
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014000566A CL2014000566A1 (es) | 2011-09-22 | 2014-10-09 | Compuestos derivados de pirrolopirimidina y purina, y sus sales farmaceuticamente aceptables; composicion farmaceutica que los comprende, util para el tratamiento del crecimiento celular anormal, tal como cancer. |
| CL2014002726A CL2014002726A1 (es) | 2011-09-22 | 2014-10-09 | Compuestos derivados de pirrolopirimidina y purina; composicion farmaceutica; utiles en el tratamiento del cancer (div. sol. 566-14). |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014000566A CL2014000566A1 (es) | 2011-09-22 | 2014-10-09 | Compuestos derivados de pirrolopirimidina y purina, y sus sales farmaceuticamente aceptables; composicion farmaceutica que los comprende, util para el tratamiento del crecimiento celular anormal, tal como cancer. |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US9040547B2 (enExample) |
| EP (1) | EP2758402B9 (enExample) |
| JP (1) | JP5914667B2 (enExample) |
| KR (1) | KR20140059246A (enExample) |
| CN (1) | CN103814030A (enExample) |
| AP (1) | AP2014007475A0 (enExample) |
| AR (1) | AR088760A1 (enExample) |
| AU (1) | AU2012311184A1 (enExample) |
| BR (1) | BR112014006840A2 (enExample) |
| CA (1) | CA2847540C (enExample) |
| CL (2) | CL2014000566A1 (enExample) |
| CO (1) | CO6910196A2 (enExample) |
| CR (1) | CR20140132A (enExample) |
| DO (1) | DOP2014000055A (enExample) |
| EA (1) | EA201490673A1 (enExample) |
| ES (1) | ES2575710T3 (enExample) |
| IL (1) | IL231592A0 (enExample) |
| MA (1) | MA35451B1 (enExample) |
| MD (1) | MD20140023A2 (enExample) |
| MX (1) | MX2014003501A (enExample) |
| NI (1) | NI201400023A (enExample) |
| PE (1) | PE20141228A1 (enExample) |
| PH (1) | PH12014500638A1 (enExample) |
| SG (1) | SG2014014450A (enExample) |
| TN (1) | TN2014000115A1 (enExample) |
| TW (1) | TWI492946B (enExample) |
| UA (1) | UA110259C2 (enExample) |
| UY (1) | UY34342A (enExample) |
| WO (1) | WO2013042006A1 (enExample) |
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| WO2011146313A1 (en) | 2010-05-19 | 2011-11-24 | The University Of North Carolina At Chapel Hill | Pyrazolopyrimidine compounds for the treatment of cancer |
| RU2598852C2 (ru) * | 2010-06-23 | 2016-09-27 | Ханми Сайенс Ко., Лтд. | Новые конденсированные пиримидиновые производные для ингибирования тирозинкиназной активности |
| US9834518B2 (en) | 2011-05-04 | 2017-12-05 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
| US9273056B2 (en) | 2011-10-03 | 2016-03-01 | The University Of North Carolina At Chapel Hill | Pyrrolopyrimidine compounds for the treatment of cancer |
| JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Egfr発動性がんの細胞増殖阻害用化合物 |
| KR20150018789A (ko) | 2012-05-22 | 2015-02-24 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | 암의 치료를 위한 피리미딘 화합물 |
| US9562047B2 (en) | 2012-10-17 | 2017-02-07 | The University Of North Carolina At Chapel Hill | Pyrazolopyrimidine compounds for the treatment of cancer |
| WO2014085225A1 (en) | 2012-11-27 | 2014-06-05 | The University Of North Carolina At Chapel Hill | Pyrimidine compounds for the treatment of cancer |
| CN105188704B (zh) | 2013-01-16 | 2017-09-19 | 西格诺药品有限公司 | 被取代的吡咯并嘧啶化合物、其组合物和使用其的治疗方法 |
| CA2904797A1 (en) * | 2013-03-14 | 2014-09-18 | Pfizer Inc. | Combination of an egfr t790m inhibitor and an egfr inhibitor for the treatment of non-small cell lung cancer |
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| KR101657616B1 (ko) * | 2013-05-24 | 2016-09-19 | 주식회사유한양행 | 피리미딘 고리를 포함하는 바이사이클릭 유도체 및 그의 제조방법 |
| CN104311573B (zh) * | 2013-09-18 | 2017-12-15 | 北京韩美药品有限公司 | 抑制btk和/或jak3激酶活性的化合物 |
| CN104513229A (zh) * | 2013-09-28 | 2015-04-15 | 正大天晴药业集团股份有限公司 | 喹唑啉衍生物及其制备方法 |
| UA115388C2 (uk) | 2013-11-21 | 2017-10-25 | Пфайзер Інк. | 2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань |
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| CN111170998B (zh) | 2014-11-05 | 2023-04-11 | 益方生物科技(上海)股份有限公司 | 嘧啶或吡啶类化合物、其制备方法和医药用途 |
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| RU2720810C2 (ru) | 2015-03-20 | 2020-05-13 | Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд. | Соли производного хиназолина и способ их получения |
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| CN112932416A (zh) | 2015-06-04 | 2021-06-11 | 松下知识产权经营株式会社 | 生物体信息检测装置及生物体信息检测方法 |
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| CN114656446A (zh) * | 2015-11-25 | 2022-06-24 | R.J.雷诺兹烟草公司 | 烟碱盐、共晶体和盐共晶体配合物 |
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| US10709708B2 (en) | 2016-03-17 | 2020-07-14 | The University Of North Carolina At Chapel Hill | Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor |
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| EP3587422A4 (en) | 2017-02-22 | 2020-05-06 | Daegu-Gyeongbuk Medical Innovation Foundation | PYRROLO-PYRIMIDINE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR THE PREVENTION OR TREATMENT OF A PROTEIN KINASE-RELATED DISEASE |
| KR102398659B1 (ko) * | 2017-03-17 | 2022-05-16 | 주식회사 대웅제약 | 카이네이즈 저해제로서의 피롤로트리아진 유도체 |
| WO2019075386A1 (en) | 2017-10-13 | 2019-04-18 | The Regents Of The University Of California | MODULATORS OF MTORC1 |
| KR20200085779A (ko) * | 2017-12-05 | 2020-07-15 | 주식회사 오스코텍 | Lrrk2 억제제로서의 피롤로(피라졸로)피리미딘 유도체 |
| KR102577242B1 (ko) * | 2017-12-28 | 2023-09-11 | 주식회사 대웅제약 | 카이네이즈 저해제로서의 아미노-메틸피페리딘 유도체 |
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- 2012-09-10 WO PCT/IB2012/054702 patent/WO2013042006A1/en not_active Ceased
- 2012-09-10 PE PE2014000403A patent/PE20141228A1/es not_active Application Discontinuation
- 2012-09-10 BR BR112014006840A patent/BR112014006840A2/pt not_active IP Right Cessation
- 2012-09-10 ES ES12780286.6T patent/ES2575710T3/es active Active
- 2012-09-10 CN CN201280045991.4A patent/CN103814030A/zh active Pending
- 2012-09-10 AP AP2014007475A patent/AP2014007475A0/xx unknown
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- 2012-09-10 EP EP12780286.6A patent/EP2758402B9/en active Active
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- 2012-09-10 AU AU2012311184A patent/AU2012311184A1/en not_active Abandoned
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