CL2014001282A1 - Uso de un inmunoconjugado de un anticuerpo dirigido contra el receptor del factor de crecimiento epidérmico (egfr) para el tratamiento del cáncer resistente al tratamiento dirigido contra egfr, donde el inmunoconjugado es un anticuerpo enlazado a un agente citotóxico. - Google Patents
Uso de un inmunoconjugado de un anticuerpo dirigido contra el receptor del factor de crecimiento epidérmico (egfr) para el tratamiento del cáncer resistente al tratamiento dirigido contra egfr, donde el inmunoconjugado es un anticuerpo enlazado a un agente citotóxico.Info
- Publication number
- CL2014001282A1 CL2014001282A1 CL2014001282A CL2014001282A CL2014001282A1 CL 2014001282 A1 CL2014001282 A1 CL 2014001282A1 CL 2014001282 A CL2014001282 A CL 2014001282A CL 2014001282 A CL2014001282 A CL 2014001282A CL 2014001282 A1 CL2014001282 A1 CL 2014001282A1
- Authority
- CL
- Chile
- Prior art keywords
- immunoconjugate
- directed against
- egfr
- treatment
- antibody
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68033—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a maytansine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161562157P | 2011-11-21 | 2011-11-21 | |
| US201261639452P | 2012-04-27 | 2012-04-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014001282A1 true CL2014001282A1 (es) | 2014-11-14 |
Family
ID=48470279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014001282A CL2014001282A1 (es) | 2011-11-21 | 2014-05-15 | Uso de un inmunoconjugado de un anticuerpo dirigido contra el receptor del factor de crecimiento epidérmico (egfr) para el tratamiento del cáncer resistente al tratamiento dirigido contra egfr, donde el inmunoconjugado es un anticuerpo enlazado a un agente citotóxico. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9233171B2 (enExample) |
| EP (1) | EP2794010A4 (enExample) |
| JP (1) | JP2014533954A (enExample) |
| KR (1) | KR20140105765A (enExample) |
| CN (1) | CN104066481A (enExample) |
| AU (1) | AU2012340686A1 (enExample) |
| BR (1) | BR112014012155A2 (enExample) |
| CA (1) | CA2856411A1 (enExample) |
| CL (1) | CL2014001282A1 (enExample) |
| HK (1) | HK1201772A1 (enExample) |
| IL (1) | IL232666A0 (enExample) |
| MX (1) | MX2014006087A (enExample) |
| PH (1) | PH12014501119A1 (enExample) |
| RU (1) | RU2014121820A (enExample) |
| SG (1) | SG11201402343SA (enExample) |
| WO (1) | WO2013078271A1 (enExample) |
Families Citing this family (18)
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| CA2815277A1 (en) | 2010-10-29 | 2012-05-03 | Immunogen, Inc. | Novel egfr-binding molecules and immunoconjugates thereof |
| JP5828902B2 (ja) | 2010-10-29 | 2015-12-09 | イミュノジェン， インコーポレイテッド | 非拮抗性ｅｇｆｒ結合分子およびその免疫複合体 |
| US10570211B2 (en) | 2011-01-24 | 2020-02-25 | Gilead Sciences, Inc. | Antibodies selective for cells presenting EGFR at high density |
| JP2014533954A (ja) | 2011-11-21 | 2014-12-18 | イミュノジェン， インコーポレイテッド | Ｅｇｆｒ抗体細胞傷害性薬物複合体による、ｅｇｆｒ療法に耐性である腫瘍の治療方法 |
| WO2015000062A1 (en) | 2013-07-05 | 2015-01-08 | Avidbiologics Inc. | Egfr antibody conjugates |
| WO2015035410A1 (en) * | 2013-09-09 | 2015-03-12 | Triact Therapeutic, Inc. | Cancer therapy |
| EP3068892A4 (en) | 2013-11-13 | 2017-05-31 | Zymeworks Inc. | Monovalent antigen binding constructs targeting egfr and/or her2 and uses thereof |
| HUE049437T2 (hu) * | 2014-02-04 | 2020-09-28 | Astellas Pharma Inc | Hatóanyagként heterociklusos diamino-karboxamid vegyületet tartalmazó gyógyászati készítmény |
| TWI731535B (zh) * | 2014-03-21 | 2021-06-21 | 美商艾伯維有限公司 | 抗-egfr抗體及抗體藥物結合物 |
| MA40539A (fr) | 2014-09-02 | 2016-03-10 | Immunogen Inc | Procédés de formulation de compositions de conjugués anticorps-médicaments |
| EP3223857A4 (en) * | 2014-10-31 | 2018-06-27 | Formation Biologics Inc. | Egfr antibody-based combination therapy |
| KR101692044B1 (ko) * | 2014-12-05 | 2017-01-04 | 사회복지법인 삼성생명공익재단 | 교모세포종에서 표피 성장인자 수용체 억제제의 치료 효과를 예측하는 방법 |
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| WO2017011618A1 (en) * | 2015-07-15 | 2017-01-19 | The Curators Of The University Of Missouri | Targeted nanoparticle conjugate and method for co-delivery of sirna and drug |
| KR102988978B1 (ko) * | 2015-12-11 | 2026-07-10 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | Cd47 및 egfr의 이중 표적화를 이용한 암의 치료 |
| US11576873B2 (en) * | 2017-03-31 | 2023-02-14 | The Curators Of The University Of Missouri | Compositions for the treatment of drug-resistant tumors and methods of use thereof |
| CN107496933B (zh) * | 2017-08-21 | 2019-12-24 | 山东新华制药股份有限公司 | 一种用于治疗胰腺癌的抗体药物偶联物及其制备方法 |
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| MX2011001927A (es) | 2008-08-29 | 2011-04-21 | Symphogen As | Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico. |
| NZ592611A (en) | 2008-10-10 | 2013-01-25 | Emergent Product Dev Seattle | A single chain fusion protein that binds to tcr complex and does not induce or induces a minimally detectable cytokine release |
| EP2359852A4 (en) | 2008-11-17 | 2015-05-20 | Nat Cancer Ct | NEW CANCERED THERAPY WITH A SUBSTANCE COMPLEX SPECIFICALLY BINDING TO A TUMOR STREAM FACTOR AND ANTITUMIR COMPOUND |
| CN102596922A (zh) * | 2009-10-06 | 2012-07-18 | 免疫基因公司 | 有效的缀合物和亲水性连接体 |
| WO2011145629A2 (ja) | 2010-05-18 | 2011-11-24 | 株式会社医学生物学研究所 | 形質転換増殖因子アルファに結合し、Ras遺伝子変異癌に対して増殖抑制活性を有する抗体 |
| CA2815277A1 (en) | 2010-10-29 | 2012-05-03 | Immunogen, Inc. | Novel egfr-binding molecules and immunoconjugates thereof |
| JP5828902B2 (ja) | 2010-10-29 | 2015-12-09 | イミュノジェン， インコーポレイテッド | 非拮抗性ｅｇｆｒ結合分子およびその免疫複合体 |
| JP2014533954A (ja) | 2011-11-21 | 2014-12-18 | イミュノジェン， インコーポレイテッド | Ｅｇｆｒ抗体細胞傷害性薬物複合体による、ｅｇｆｒ療法に耐性である腫瘍の治療方法 |
-
2012
- 2012-11-21 JP JP2014542584A patent/JP2014533954A/ja active Pending
- 2012-11-21 MX MX2014006087A patent/MX2014006087A/es not_active Application Discontinuation
- 2012-11-21 CA CA2856411A patent/CA2856411A1/en not_active Abandoned
- 2012-11-21 SG SG11201402343SA patent/SG11201402343SA/en unknown
- 2012-11-21 CN CN201280056769.4A patent/CN104066481A/zh active Pending
- 2012-11-21 EP EP12850911.4A patent/EP2794010A4/en not_active Withdrawn
- 2012-11-21 WO PCT/US2012/066205 patent/WO2013078271A1/en not_active Ceased
- 2012-11-21 RU RU2014121820/15A patent/RU2014121820A/ru not_active Application Discontinuation
- 2012-11-21 BR BR112014012155A patent/BR112014012155A2/pt not_active IP Right Cessation
- 2012-11-21 KR KR1020147016745A patent/KR20140105765A/ko not_active Withdrawn
- 2012-11-21 HK HK15102403.0A patent/HK1201772A1/xx unknown
- 2012-11-21 AU AU2012340686A patent/AU2012340686A1/en not_active Abandoned
- 2012-11-21 US US13/682,948 patent/US9233171B2/en not_active Expired - Fee Related
-
2014
- 2014-05-15 CL CL2014001282A patent/CL2014001282A1/es unknown
- 2014-05-18 IL IL232666A patent/IL232666A0/en unknown
- 2014-05-19 PH PH12014501119A patent/PH12014501119A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2014121820A (ru) | 2015-12-27 |
| SG11201402343SA (en) | 2014-06-27 |
| PH12014501119A1 (en) | 2014-08-04 |
| WO2013078271A1 (en) | 2013-05-30 |
| KR20140105765A (ko) | 2014-09-02 |
| BR112014012155A2 (pt) | 2017-05-30 |
| MX2014006087A (es) | 2014-08-01 |
| AU2012340686A1 (en) | 2014-06-19 |
| HK1201772A1 (en) | 2015-09-11 |
| IL232666A0 (en) | 2014-07-31 |
| EP2794010A1 (en) | 2014-10-29 |
| US9233171B2 (en) | 2016-01-12 |
| JP2014533954A (ja) | 2014-12-18 |
| US20130156796A1 (en) | 2013-06-20 |
| CA2856411A1 (en) | 2013-05-30 |
| CN104066481A (zh) | 2014-09-24 |
| EP2794010A4 (en) | 2015-10-21 |
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