CA2856411A1 - Method of treatment of tumors that are resistant to egfr therapies by egfr antibody cytotoxic agent conjugate - Google Patents
Method of treatment of tumors that are resistant to egfr therapies by egfr antibody cytotoxic agent conjugate Download PDFInfo
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- CA2856411A1 CA2856411A1 CA2856411A CA2856411A CA2856411A1 CA 2856411 A1 CA2856411 A1 CA 2856411A1 CA 2856411 A CA2856411 A CA 2856411A CA 2856411 A CA2856411 A CA 2856411A CA 2856411 A1 CA2856411 A1 CA 2856411A1
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68033—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a maytansine
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Landscapes
- Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US201161562157P | 2011-11-21 | 2011-11-21 | |
| US61/562,157 | 2011-11-21 | ||
| US201261639452P | 2012-04-27 | 2012-04-27 | |
| US61/639,452 | 2012-04-27 | ||
| PCT/US2012/066205 WO2013078271A1 (en) | 2011-11-21 | 2012-11-21 | Method of treatment of tumors that are resistant to egfr therapies by egfr antibody cytotoxic agent conjugate |
Publications (1)
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| CA2856411A1 true CA2856411A1 (en) | 2013-05-30 |
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| CA2856411A Abandoned CA2856411A1 (en) | 2011-11-21 | 2012-11-21 | Method of treatment of tumors that are resistant to egfr therapies by egfr antibody cytotoxic agent conjugate |
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|---|---|
| US (1) | US9233171B2 (enExample) |
| EP (1) | EP2794010A4 (enExample) |
| JP (1) | JP2014533954A (enExample) |
| KR (1) | KR20140105765A (enExample) |
| CN (1) | CN104066481A (enExample) |
| AU (1) | AU2012340686A1 (enExample) |
| BR (1) | BR112014012155A2 (enExample) |
| CA (1) | CA2856411A1 (enExample) |
| CL (1) | CL2014001282A1 (enExample) |
| HK (1) | HK1201772A1 (enExample) |
| IL (1) | IL232666A0 (enExample) |
| MX (1) | MX2014006087A (enExample) |
| PH (1) | PH12014501119A1 (enExample) |
| RU (1) | RU2014121820A (enExample) |
| SG (1) | SG11201402343SA (enExample) |
| WO (1) | WO2013078271A1 (enExample) |
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| EA201390575A1 (ru) | 2010-10-29 | 2014-01-30 | Иммьюноджен, Инк. | Неантагонистические egfr-связывающие молекулы и их иммуноконъюгаты |
| AU2011320314B2 (en) | 2010-10-29 | 2015-08-06 | Immunogen, Inc. | Novel EGFR-binding molecules and immunoconjugates thereof |
| AU2012211014A1 (en) | 2011-01-24 | 2013-05-02 | National Research Council Of Canada | Antibodies selective for cells presenting EGFR at high density |
| SG11201402343SA (en) | 2011-11-21 | 2014-06-27 | Immunogen Inc | Method of treatment of tumors that are resistant to egfr therapies by egfr antibody cytotoxic agent conjugate |
| WO2015000062A1 (en) | 2013-07-05 | 2015-01-08 | Avidbiologics Inc. | Egfr antibody conjugates |
| EP3044593A4 (en) * | 2013-09-09 | 2017-05-17 | Triact Therapeutics, Inc. | Cancer therapy |
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-
2012
- 2012-11-21 SG SG11201402343SA patent/SG11201402343SA/en unknown
- 2012-11-21 AU AU2012340686A patent/AU2012340686A1/en not_active Abandoned
- 2012-11-21 EP EP12850911.4A patent/EP2794010A4/en not_active Withdrawn
- 2012-11-21 HK HK15102403.0A patent/HK1201772A1/xx unknown
- 2012-11-21 CN CN201280056769.4A patent/CN104066481A/zh active Pending
- 2012-11-21 WO PCT/US2012/066205 patent/WO2013078271A1/en not_active Ceased
- 2012-11-21 KR KR1020147016745A patent/KR20140105765A/ko not_active Withdrawn
- 2012-11-21 US US13/682,948 patent/US9233171B2/en not_active Expired - Fee Related
- 2012-11-21 JP JP2014542584A patent/JP2014533954A/ja active Pending
- 2012-11-21 RU RU2014121820/15A patent/RU2014121820A/ru not_active Application Discontinuation
- 2012-11-21 MX MX2014006087A patent/MX2014006087A/es not_active Application Discontinuation
- 2012-11-21 CA CA2856411A patent/CA2856411A1/en not_active Abandoned
- 2012-11-21 BR BR112014012155A patent/BR112014012155A2/pt not_active IP Right Cessation
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2014
- 2014-05-15 CL CL2014001282A patent/CL2014001282A1/es unknown
- 2014-05-18 IL IL232666A patent/IL232666A0/en unknown
- 2014-05-19 PH PH12014501119A patent/PH12014501119A1/en unknown
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| RU2014121820A (ru) | 2015-12-27 |
| SG11201402343SA (en) | 2014-06-27 |
| MX2014006087A (es) | 2014-08-01 |
| WO2013078271A1 (en) | 2013-05-30 |
| US20130156796A1 (en) | 2013-06-20 |
| AU2012340686A1 (en) | 2014-06-19 |
| JP2014533954A (ja) | 2014-12-18 |
| CL2014001282A1 (es) | 2014-11-14 |
| BR112014012155A2 (pt) | 2017-05-30 |
| IL232666A0 (en) | 2014-07-31 |
| US9233171B2 (en) | 2016-01-12 |
| EP2794010A1 (en) | 2014-10-29 |
| PH12014501119A1 (en) | 2014-08-04 |
| CN104066481A (zh) | 2014-09-24 |
| KR20140105765A (ko) | 2014-09-02 |
| EP2794010A4 (en) | 2015-10-21 |
| HK1201772A1 (en) | 2015-09-11 |
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