CL2014000494A1 - Compuestos derivados de imidazo[1,2-a]piridina, como inhibidores de las quinasas pdgfr y/o c-kit; composicion farmaceutica que los comprende; y su uso para tratar una enfermedad asociada con mastocitos, una enfermedad respiratoria, una enfermedad metabolica, un trastorno autoinmune, una enfermedad dermatologica, entre otras. - Google Patents

Compuestos derivados de imidazo[1,2-a]piridina, como inhibidores de las quinasas pdgfr y/o c-kit; composicion farmaceutica que los comprende; y su uso para tratar una enfermedad asociada con mastocitos, una enfermedad respiratoria, una enfermedad metabolica, un trastorno autoinmune, una enfermedad dermatologica, entre otras.

Info

Publication number
CL2014000494A1
CL2014000494A1 CL2014000494A CL2014000494A CL2014000494A1 CL 2014000494 A1 CL2014000494 A1 CL 2014000494A1 CL 2014000494 A CL2014000494 A CL 2014000494A CL 2014000494 A CL2014000494 A CL 2014000494A CL 2014000494 A1 CL2014000494 A1 CL 2014000494A1
Authority
CL
Chile
Prior art keywords
disease
pdgfr
imidazo
pyridine
inhibitors
Prior art date
Application number
CL2014000494A
Other languages
English (en)
Spanish (es)
Inventor
Valentina Molteni
Vince Yeh
Xiaolin Li
Xiaodong Liu
Jon Loren
Juliet Nabakka
Bao Nguyen
Hank Michael James Petrassi
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of CL2014000494A1 publication Critical patent/CL2014000494A1/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/04Drugs for disorders of the respiratory system for throat disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
CL2014000494A 2011-09-01 2014-02-27 Compuestos derivados de imidazo[1,2-a]piridina, como inhibidores de las quinasas pdgfr y/o c-kit; composicion farmaceutica que los comprende; y su uso para tratar una enfermedad asociada con mastocitos, una enfermedad respiratoria, una enfermedad metabolica, un trastorno autoinmune, una enfermedad dermatologica, entre otras. CL2014000494A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161530028P 2011-09-01 2011-09-01

Publications (1)

Publication Number Publication Date
CL2014000494A1 true CL2014000494A1 (es) 2014-09-05

Family

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Family Applications (1)

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CL2014000494A CL2014000494A1 (es) 2011-09-01 2014-02-27 Compuestos derivados de imidazo[1,2-a]piridina, como inhibidores de las quinasas pdgfr y/o c-kit; composicion farmaceutica que los comprende; y su uso para tratar una enfermedad asociada con mastocitos, una enfermedad respiratoria, una enfermedad metabolica, un trastorno autoinmune, una enfermedad dermatologica, entre otras.

Country Status (42)

Country Link
US (1) US9199981B2 (enExample)
EP (1) EP2751102B1 (enExample)
JP (1) JP6117208B2 (enExample)
KR (1) KR101959590B1 (enExample)
CN (1) CN103764653B (enExample)
AP (1) AP2014007494A0 (enExample)
AR (1) AR087752A1 (enExample)
AU (1) AU2012300248B2 (enExample)
BR (1) BR112014004504B1 (enExample)
CA (1) CA2845159C (enExample)
CL (1) CL2014000494A1 (enExample)
CO (1) CO6900140A2 (enExample)
CR (1) CR20140106A (enExample)
CU (1) CU20140023A7 (enExample)
CY (1) CY1121695T1 (enExample)
DK (1) DK2751102T3 (enExample)
EA (1) EA024293B1 (enExample)
ES (1) ES2732671T3 (enExample)
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JO (1) JOP20120246B1 (enExample)
LT (1) LT2751102T (enExample)
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ME (1) ME03395B (enExample)
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MY (1) MY167245A (enExample)
PE (1) PE20141033A1 (enExample)
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PL (1) PL2751102T3 (enExample)
PT (1) PT2751102T (enExample)
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SG (1) SG2014011050A (enExample)
SI (1) SI2751102T1 (enExample)
TN (1) TN2014000061A1 (enExample)
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UA (1) UA110841C2 (enExample)
UY (1) UY34300A (enExample)
WO (1) WO2013033070A1 (enExample)
ZA (1) ZA201401113B (enExample)

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JP2023551434A (ja) 2020-11-19 2023-12-08 サード ハーモニック バイオ, インコーポレイテッド 選択的c-kitキナーゼ阻害剤の医薬組成物ならびにその作製および使用のための方法
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Also Published As

Publication number Publication date
IL231226A (en) 2017-03-30
RS59025B1 (sr) 2019-08-30
NZ621092A (en) 2016-06-24
TR201909189T4 (tr) 2019-07-22
MX342329B (es) 2016-09-26
ES2732671T3 (es) 2019-11-25
TWI543981B (zh) 2016-08-01
EP2751102B1 (en) 2019-03-27
SI2751102T1 (sl) 2019-08-30
PL2751102T3 (pl) 2019-09-30
UY34300A (es) 2013-04-05
IL231226A0 (en) 2014-04-30
HUE044373T2 (hu) 2019-10-28
BR112014004504A2 (pt) 2017-03-28
MX2014002482A (es) 2014-11-25
TW201313716A (zh) 2013-04-01
JP6117208B2 (ja) 2017-04-19
JOP20120246B1 (ar) 2022-03-14
AU2012300248A1 (en) 2014-04-17
KR20140071382A (ko) 2014-06-11
TN2014000061A1 (en) 2015-07-01
AR087752A1 (es) 2014-04-16
ME03395B (me) 2020-01-20
US20130059846A1 (en) 2013-03-07
CA2845159A1 (en) 2013-03-07
AU2012300248B2 (en) 2015-08-27
EA201490540A1 (ru) 2014-06-30
PT2751102T (pt) 2019-07-10
CR20140106A (es) 2014-05-02
CN103764653B (zh) 2015-12-02
AP2014007494A0 (en) 2014-03-31
PH12014500351A1 (en) 2014-04-07
KR101959590B1 (ko) 2019-03-18
CO6900140A2 (es) 2014-03-20
CU20140023A7 (es) 2014-04-24
DK2751102T3 (da) 2019-07-01
MA35459B1 (fr) 2014-09-01
EP2751102A1 (en) 2014-07-09
CA2845159C (en) 2020-11-03
PH12014500351B1 (en) 2019-04-03
HRP20191140T1 (hr) 2019-09-20
JP2014525444A (ja) 2014-09-29
MY167245A (en) 2018-08-14
WO2013033070A1 (en) 2013-03-07
EA024293B1 (ru) 2016-09-30
ZA201401113B (en) 2015-10-28
SG2014011050A (en) 2014-08-28
UA110841C2 (uk) 2016-02-25
CY1121695T1 (el) 2020-07-31
PE20141033A1 (es) 2014-08-30
BR112014004504B1 (pt) 2022-03-22
US9199981B2 (en) 2015-12-01
CN103764653A (zh) 2014-04-30
GT201400036A (es) 2015-06-02
LT2751102T (lt) 2019-07-10

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