CL2013002195A1 - Miméticos de las moléculas mir-34a y mir-34c, composiciones farmacéuticas que los comprenden, y su uso para inhibir la proliferación celular e inducir apoptosis de células cancerosas. - Google Patents

Miméticos de las moléculas mir-34a y mir-34c, composiciones farmacéuticas que los comprenden, y su uso para inhibir la proliferación celular e inducir apoptosis de células cancerosas.

Info

Publication number
CL2013002195A1
CL2013002195A1 CL2013002195A CL2013002195A CL2013002195A1 CL 2013002195 A1 CL2013002195 A1 CL 2013002195A1 CL 2013002195 A CL2013002195 A CL 2013002195A CL 2013002195 A CL2013002195 A CL 2013002195A CL 2013002195 A1 CL2013002195 A1 CL 2013002195A1
Authority
CL
Chile
Prior art keywords
mir
mimetics
molecules
pharmaceutical compositions
cancer cells
Prior art date
Application number
CL2013002195A
Other languages
English (en)
Inventor
Kevin Kelnar
David Brown
Original Assignee
Mirna Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mirna Therapeutics Inc filed Critical Mirna Therapeutics Inc
Publication of CL2013002195A1 publication Critical patent/CL2013002195A1/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CL2013002195A 2011-02-03 2013-07-31 Miméticos de las moléculas mir-34a y mir-34c, composiciones farmacéuticas que los comprenden, y su uso para inhibir la proliferación celular e inducir apoptosis de células cancerosas. CL2013002195A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161439280P 2011-02-03 2011-02-03

Publications (1)

Publication Number Publication Date
CL2013002195A1 true CL2013002195A1 (es) 2014-05-30

Family

ID=45592829

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2013002195A CL2013002195A1 (es) 2011-02-03 2013-07-31 Miméticos de las moléculas mir-34a y mir-34c, composiciones farmacéuticas que los comprenden, y su uso para inhibir la proliferación celular e inducir apoptosis de células cancerosas.

Country Status (16)

Country Link
US (3) US8586727B2 (es)
EP (2) EP3178932A1 (es)
JP (2) JP2014506791A (es)
KR (1) KR20140020900A (es)
CN (1) CN103476931A (es)
AU (1) AU2012212023B9 (es)
BR (1) BR112013019853A2 (es)
CA (1) CA2825981A1 (es)
CL (1) CL2013002195A1 (es)
IL (1) IL227697A0 (es)
MX (1) MX342927B (es)
MY (1) MY165507A (es)
RU (1) RU2615117C2 (es)
SG (2) SG192252A1 (es)
WO (1) WO2012106591A1 (es)
ZA (1) ZA201306518B (es)

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AU2012212023B9 (en) 2011-02-03 2017-01-12 Mirna Therapeutics, Inc. Synthetic mimics of miR-34
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US20140308274A1 (en) * 2013-03-15 2014-10-16 Mirna Therapeutics, Inc. Combination cancer treatments utilizing synthetic oligonucleotides and egfr-tki inhibitors
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US10934542B2 (en) * 2013-12-27 2021-03-02 Bonac Corporation Artificial match-type miRNA for controlling gene expression and use therefor
JP6492014B2 (ja) * 2013-12-27 2019-03-27 株式会社ボナック 遺伝子発現制御のための人工マッチ型ｍｉＲＮＡおよびその用途
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Also Published As

Publication number Publication date
EP3178932A1 (en) 2017-06-14
ZA201306518B (en) 2014-05-28
KR20140020900A (ko) 2014-02-19
US20160053264A1 (en) 2016-02-25
SG10201600836PA (en) 2016-03-30
AU2012212023A1 (en) 2013-09-12
JP2014506791A (ja) 2014-03-20
MY165507A (en) 2018-03-28
MX342927B (es) 2016-10-19
JP2016152804A (ja) 2016-08-25
MX2013008945A (es) 2014-01-08
CN103476931A (zh) 2013-12-25
US9371526B2 (en) 2016-06-21
US20120288933A1 (en) 2012-11-15
SG192252A1 (en) 2013-09-30
US8586727B2 (en) 2013-11-19
RU2615117C2 (ru) 2017-04-04
WO2012106591A1 (en) 2012-08-09
AU2012212023B2 (en) 2017-01-05
EP2670850B1 (en) 2016-10-26
US20140107182A1 (en) 2014-04-17
RU2013140634A (ru) 2015-03-10
EP2670850A1 (en) 2013-12-11
CA2825981A1 (en) 2012-08-09
BR112013019853A2 (pt) 2017-03-21
AU2012212023B9 (en) 2017-01-12
IL227697A0 (en) 2013-09-30

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