PH12014500351B1 - COMPOUNDS AND COMPOSITIONS AS c-KIT KINASE INHIBITORS - Google Patents

COMPOUNDS AND COMPOSITIONS AS c-KIT KINASE INHIBITORS

Info

Publication number
PH12014500351B1
PH12014500351B1 PH1/2014/500351A PH12014500351A PH12014500351B1 PH 12014500351 B1 PH12014500351 B1 PH 12014500351B1 PH 12014500351 A PH12014500351 A PH 12014500351A PH 12014500351 B1 PH12014500351 B1 PH 12014500351B1
Authority
PH
Philippines
Prior art keywords
compounds
kinase inhibitors
compositions
kit
kit kinase
Prior art date
Application number
PH1/2014/500351A
Other languages
English (en)
Other versions
PH12014500351A1 (en
Inventor
Xiaolin Li
Xiaodong Liu
Jon Loren
Valentina Molteni
Juliet Nabakka
Bao Nguyen
Hank Michael James Petrassi
Vince Yeh
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PH12014500351A1 publication Critical patent/PH12014500351A1/en
Publication of PH12014500351B1 publication Critical patent/PH12014500351B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/04Drugs for disorders of the respiratory system for throat disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
PH1/2014/500351A 2011-09-01 2012-08-28 COMPOUNDS AND COMPOSITIONS AS c-KIT KINASE INHIBITORS PH12014500351B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161530028P 2011-09-01 2011-09-01
PCT/US2012/052621 WO2013033070A1 (en) 2011-09-01 2012-08-28 COMPOUNDS AND COMPOSITIONS AS c-KIT KINASE INHIBITORS

Publications (2)

Publication Number Publication Date
PH12014500351A1 PH12014500351A1 (en) 2014-04-07
PH12014500351B1 true PH12014500351B1 (en) 2019-04-03

Family

ID=46829898

Family Applications (1)

Application Number Title Priority Date Filing Date
PH1/2014/500351A PH12014500351B1 (en) 2011-09-01 2012-08-28 COMPOUNDS AND COMPOSITIONS AS c-KIT KINASE INHIBITORS

Country Status (42)

Country Link
US (1) US9199981B2 (enExample)
EP (1) EP2751102B1 (enExample)
JP (1) JP6117208B2 (enExample)
KR (1) KR101959590B1 (enExample)
CN (1) CN103764653B (enExample)
AP (1) AP2014007494A0 (enExample)
AR (1) AR087752A1 (enExample)
AU (1) AU2012300248B2 (enExample)
BR (1) BR112014004504B1 (enExample)
CA (1) CA2845159C (enExample)
CL (1) CL2014000494A1 (enExample)
CO (1) CO6900140A2 (enExample)
CR (1) CR20140106A (enExample)
CU (1) CU20140023A7 (enExample)
CY (1) CY1121695T1 (enExample)
DK (1) DK2751102T3 (enExample)
EA (1) EA024293B1 (enExample)
ES (1) ES2732671T3 (enExample)
GT (1) GT201400036A (enExample)
HR (1) HRP20191140T1 (enExample)
HU (1) HUE044373T2 (enExample)
IL (1) IL231226A (enExample)
JO (1) JOP20120246B1 (enExample)
LT (1) LT2751102T (enExample)
MA (1) MA35459B1 (enExample)
ME (1) ME03395B (enExample)
MX (1) MX342329B (enExample)
MY (1) MY167245A (enExample)
PE (1) PE20141033A1 (enExample)
PH (1) PH12014500351B1 (enExample)
PL (1) PL2751102T3 (enExample)
PT (1) PT2751102T (enExample)
RS (1) RS59025B1 (enExample)
SG (1) SG2014011050A (enExample)
SI (1) SI2751102T1 (enExample)
TN (1) TN2014000061A1 (enExample)
TR (1) TR201909189T4 (enExample)
TW (1) TWI543981B (enExample)
UA (1) UA110841C2 (enExample)
UY (1) UY34300A (enExample)
WO (1) WO2013033070A1 (enExample)
ZA (1) ZA201401113B (enExample)

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US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
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MA42293A (fr) 2015-07-02 2018-05-09 Janssen Sciences Ireland Uc Composés antibactériens
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CN111039946A (zh) * 2018-10-15 2020-04-21 上海轶诺药业有限公司 一类咪唑并芳环类化合物的制备和应用
KR20210142154A (ko) 2019-03-21 2021-11-24 옹쎄오 암 치료를 위한 키나제 억제제와 조합된 dbait 분자
MX2021013814A (es) * 2019-05-13 2022-02-10 Novartis Ag Formas cristalinas de n-(5-(5-((1r,2s)-2-fluorociclopropil)-1,2,4- oxadiazol-3-yl)-2- metilfenil)imidazo[1,2-a]piridin-3-carboxamida.
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WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
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WO2022016021A1 (en) * 2020-07-15 2022-01-20 Third Harmonic Bio, Inc. Crystalline forms of a selective c-kit kinase inhibitor
WO2022106615A1 (en) 2020-11-19 2022-05-27 Novartis Ag Pharmaceutical compositions of a selective c-kit kinase inhibitor and methods for making and using same
JP2023551434A (ja) 2020-11-19 2023-12-08 サード ハーモニック バイオ, インコーポレイテッド 選択的c-kitキナーゼ阻害剤の医薬組成物ならびにその作製および使用のための方法
WO2022182982A1 (en) * 2021-02-26 2022-09-01 Third Harmonic Bio, Inc. Methods for treating c-kit kinase mediated diseases and disorders using a selective c-kit kinase inhibitor
MX2023010947A (es) 2021-03-16 2023-11-29 Janssen Sciences Ireland Unlimited Co Compuestos antibacterianos.
KR20230158046A (ko) 2021-03-17 2023-11-17 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 항박테리아성 화합물
US20240182495A1 (en) 2021-03-17 2024-06-06 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
CA3234515A1 (en) 2021-10-28 2023-05-04 Jose Manuel Bartolome-Nebreda Imidazopyridine amides and related compounds for use in the treatment of bacterial infections
WO2024089170A1 (en) 2022-10-27 2024-05-02 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
CN120677154A (zh) 2022-11-30 2025-09-19 缆图药品公司 用于治疗荨麻疹的作为野生型c-kit激酶抑制剂的n-苯基-吡唑并[1,5-a]吡啶-3-甲酰胺衍生物
JP2025541191A (ja) * 2022-12-07 2025-12-18 サード ハーモニック バイオ, インコーポレイテッド C-kitキナーゼ阻害剤としての化合物及び組成物
KR20250129682A (ko) * 2022-12-07 2025-08-29 써드 하모닉 바이오, 인크. C-kit 키나제 억제제로서의 화합물 및 조성물
WO2024223859A1 (en) 2023-04-26 2024-10-31 Janssen Pharmaceutica Nv Antibacterial compounds
WO2025024503A1 (en) * 2023-07-25 2025-01-30 Enanta Pharmaceuticals, Inc. PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS AS c-KIT KINASE INHIBITORS
US12384773B2 (en) 2023-11-02 2025-08-12 Arcus Biosciences, Inc. Thiazole compounds and methods of use thereof
WO2025146196A1 (zh) * 2024-01-04 2025-07-10 上海翰森生物医药科技有限公司 多环类衍生物抑制剂、其制备方法和应用

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Also Published As

Publication number Publication date
MX2014002482A (es) 2014-11-25
EP2751102B1 (en) 2019-03-27
CL2014000494A1 (es) 2014-09-05
UA110841C2 (uk) 2016-02-25
LT2751102T (lt) 2019-07-10
MA35459B1 (fr) 2014-09-01
CA2845159A1 (en) 2013-03-07
US20130059846A1 (en) 2013-03-07
AU2012300248B2 (en) 2015-08-27
CA2845159C (en) 2020-11-03
AU2012300248A1 (en) 2014-04-17
PT2751102T (pt) 2019-07-10
NZ621092A (en) 2016-06-24
TR201909189T4 (tr) 2019-07-22
US9199981B2 (en) 2015-12-01
IL231226A0 (en) 2014-04-30
PH12014500351A1 (en) 2014-04-07
HRP20191140T1 (hr) 2019-09-20
JP2014525444A (ja) 2014-09-29
DK2751102T3 (da) 2019-07-01
GT201400036A (es) 2015-06-02
JOP20120246B1 (ar) 2022-03-14
EA024293B1 (ru) 2016-09-30
CO6900140A2 (es) 2014-03-20
AP2014007494A0 (en) 2014-03-31
CY1121695T1 (el) 2020-07-31
CR20140106A (es) 2014-05-02
KR101959590B1 (ko) 2019-03-18
EA201490540A1 (ru) 2014-06-30
EP2751102A1 (en) 2014-07-09
ME03395B (me) 2020-01-20
CN103764653A (zh) 2014-04-30
BR112014004504A2 (pt) 2017-03-28
UY34300A (es) 2013-04-05
WO2013033070A1 (en) 2013-03-07
PL2751102T3 (pl) 2019-09-30
KR20140071382A (ko) 2014-06-11
TN2014000061A1 (en) 2015-07-01
MX342329B (es) 2016-09-26
CN103764653B (zh) 2015-12-02
MY167245A (en) 2018-08-14
SI2751102T1 (sl) 2019-08-30
ZA201401113B (en) 2015-10-28
PE20141033A1 (es) 2014-08-30
IL231226A (en) 2017-03-30
HUE044373T2 (hu) 2019-10-28
JP6117208B2 (ja) 2017-04-19
CU20140023A7 (es) 2014-04-24
BR112014004504B1 (pt) 2022-03-22
SG2014011050A (en) 2014-08-28
RS59025B1 (sr) 2019-08-30
ES2732671T3 (es) 2019-11-25
AR087752A1 (es) 2014-04-16
TWI543981B (zh) 2016-08-01
TW201313716A (zh) 2013-04-01

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