CL2013003248A1 - Composición inmunogenica que comprende una glucoproteina g de los virus hendra y nipah y un complejo inmunoestimulante; método para producir una respuesta de anticuerpo neutralizante contra un virus hendra y/o nipah en un sujeto. - Google Patents

Composición inmunogenica que comprende una glucoproteina g de los virus hendra y nipah y un complejo inmunoestimulante; método para producir una respuesta de anticuerpo neutralizante contra un virus hendra y/o nipah en un sujeto.

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Publication number
CL2013003248A1
CL2013003248A1 CL2013003248A CL2013003248A CL2013003248A1 CL 2013003248 A1 CL2013003248 A1 CL 2013003248A1 CL 2013003248 A CL2013003248 A CL 2013003248A CL 2013003248 A CL2013003248 A CL 2013003248A CL 2013003248 A1 CL2013003248 A1 CL 2013003248A1
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CL
Chile
Prior art keywords
hendra
subject
immunogenic composition
glycoprotein
nipah
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CL2013003248A
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English (en)
Inventor
Marin Elhay
Christopher C Broder
jin-an Huang
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Henry M Jackson Found Advancement Military Medicine Inc
Zoetis Services Llc
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Application filed by Henry M Jackson Found Advancement Military Medicine Inc, Zoetis Services Llc filed Critical Henry M Jackson Found Advancement Military Medicine Inc
Publication of CL2013003248A1 publication Critical patent/CL2013003248A1/es

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    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
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    • A61P31/12—Antivirals
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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Abstract

La invención se relaciona con una composición inmunogénica porque comprende una glucoproteína G de los virus Hendra donde dicho fragmento consiste en los aminoácidos 73 a 604 de (SEQ ID N° 2) o una secuencia al menos 90% idéntica de la misma, un complejo inmunoestimulante (ISC) donde dicho complejo ISC comprende una saponina, un fosfolípido y un esteroide; y uno o más excipientes, donde la concentración del fragmento soluble de la glucoproteína G del virus Hendra en la composición es de 5-100 ?g/ml de ISC y donde dicha composición suscita la producción de anticuerpos neutralizantes contra el virus Hendra después de su administración a un sujeto. Así mismo reivindica un método para diferenciar un sujeto vacunado con la composición inmunogénica del invento, de un sujeto expuesto a un virus Hendra y/o Nipah porque comprende detectar la presencia de un anticuerpo en una muestra biológica aislada del sujeto contra por lo menos una de cualquiera de las siguientes proteínas virales HeV y/o NiV seleccionadas del grupo que consiste en una proteína de fusión (F), una proteína de la matriz (M), una fosfoproteína (P), una proteína grande (L) y una proteína de la nucleocápside (N). Además, describe el uso de la composición inmunogénica del invento porque sirve para la fabricación de un medicamento útil en el tratamiento de un sujeto con una infección de virus Hendra.
CL2013003248A 2011-05-13 2013-11-13 Composición inmunogenica que comprende una glucoproteina g de los virus hendra y nipah y un complejo inmunoestimulante; método para producir una respuesta de anticuerpo neutralizante contra un virus hendra y/o nipah en un sujeto. CL2013003248A1 (es)

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US (1) US20150050305A1 (es)
EP (2) EP2707025B8 (es)
JP (4) JP2014516955A (es)
KR (2) KR20140053906A (es)
CN (2) CN104244974A (es)
AU (2) AU2012256000B2 (es)
BR (1) BR112013029309A8 (es)
CA (1) CA2836098C (es)
CL (1) CL2013003248A1 (es)
CO (1) CO6940373A2 (es)
ES (2) ES2963147T3 (es)
HK (1) HK1247833A1 (es)
MX (1) MX352604B (es)
PT (1) PT2707025T (es)
RU (1) RU2681529C2 (es)
UA (1) UA114086C2 (es)
WO (1) WO2012158643A1 (es)
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AU2017213501A1 (en) 2017-08-31
EP3251692B1 (en) 2023-09-27
CO6940373A2 (es) 2014-05-09
ZA201308701B (en) 2015-08-26
RU2019104307A (ru) 2019-04-15
RU2681529C2 (ru) 2019-03-07
RU2013155470A (ru) 2015-06-20
JP2018030862A (ja) 2018-03-01
ES2639122T3 (es) 2017-10-25
MX352604B (es) 2017-11-30
BR112013029309A8 (pt) 2018-01-23
JP2019142909A (ja) 2019-08-29
EP2707025B8 (en) 2017-08-23
JP2014516955A (ja) 2014-07-17
UA114086C2 (xx) 2017-04-25
NZ617722A (en) 2016-03-31
BR112013029309A2 (pt) 2017-06-20
HK1247833A1 (zh) 2018-10-05
ES2963147T3 (es) 2024-03-25
JP6898024B2 (ja) 2021-07-07
JP2017193537A (ja) 2017-10-26
WO2012158643A1 (en) 2012-11-22
US20150050305A1 (en) 2015-02-19
EP2707025B1 (en) 2017-07-12
EP3251692A1 (en) 2017-12-06
CA2836098A1 (en) 2012-11-22
EP2707025A4 (en) 2014-12-17
KR20140053906A (ko) 2014-05-08
KR20200040899A (ko) 2020-04-20
PT2707025T (pt) 2017-08-31
CA2836098C (en) 2022-06-21
CN110680913A (zh) 2020-01-14
MX2013013277A (es) 2014-09-22
AU2012256000B2 (en) 2017-05-11
EP2707025A1 (en) 2014-03-19
CN104244974A (zh) 2014-12-24
AU2012256000A1 (en) 2013-12-12

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