CL2013003248A1 - Composición inmunogenica que comprende una glucoproteina g de los virus hendra y nipah y un complejo inmunoestimulante; método para producir una respuesta de anticuerpo neutralizante contra un virus hendra y/o nipah en un sujeto. - Google Patents
Composición inmunogenica que comprende una glucoproteina g de los virus hendra y nipah y un complejo inmunoestimulante; método para producir una respuesta de anticuerpo neutralizante contra un virus hendra y/o nipah en un sujeto.Info
- Publication number
- CL2013003248A1 CL2013003248A1 CL2013003248A CL2013003248A CL2013003248A1 CL 2013003248 A1 CL2013003248 A1 CL 2013003248A1 CL 2013003248 A CL2013003248 A CL 2013003248A CL 2013003248 A CL2013003248 A CL 2013003248A CL 2013003248 A1 CL2013003248 A1 CL 2013003248A1
- Authority
- CL
- Chile
- Prior art keywords
- hendra
- subject
- immunogenic composition
- glycoprotein
- nipah
- Prior art date
Links
- 241000893570 Hendra henipavirus Species 0.000 title abstract 6
- 230000002163 immunogen Effects 0.000 title abstract 4
- 241000526636 Nipah henipavirus Species 0.000 title abstract 3
- 108010046722 Thrombospondin 1 Proteins 0.000 title abstract 2
- 102100036034 Thrombospondin-1 Human genes 0.000 title abstract 2
- 230000003308 immunostimulating effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000003472 neutralizing effect Effects 0.000 title abstract 2
- 230000005875 antibody response Effects 0.000 title 1
- 239000012634 fragment Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108060003393 Granulin Proteins 0.000 abstract 1
- 208000025164 Hendra virus infection Diseases 0.000 abstract 1
- 208000000464 Henipavirus Infections Diseases 0.000 abstract 1
- 102000007982 Phosphoproteins Human genes 0.000 abstract 1
- 108010089430 Phosphoproteins Proteins 0.000 abstract 1
- 108010067390 Viral Proteins Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 abstract 1
- 229930182490 saponin Natural products 0.000 abstract 1
- 150000007949 saponins Chemical class 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
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- A—HUMAN NECESSITIES
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- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
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Abstract
La invención se relaciona con una composición inmunogénica porque comprende una glucoproteína G de los virus Hendra donde dicho fragmento consiste en los aminoácidos 73 a 604 de (SEQ ID N° 2) o una secuencia al menos 90% idéntica de la misma, un complejo inmunoestimulante (ISC) donde dicho complejo ISC comprende una saponina, un fosfolípido y un esteroide; y uno o más excipientes, donde la concentración del fragmento soluble de la glucoproteína G del virus Hendra en la composición es de 5-100 ?g/ml de ISC y donde dicha composición suscita la producción de anticuerpos neutralizantes contra el virus Hendra después de su administración a un sujeto. Así mismo reivindica un método para diferenciar un sujeto vacunado con la composición inmunogénica del invento, de un sujeto expuesto a un virus Hendra y/o Nipah porque comprende detectar la presencia de un anticuerpo en una muestra biológica aislada del sujeto contra por lo menos una de cualquiera de las siguientes proteínas virales HeV y/o NiV seleccionadas del grupo que consiste en una proteína de fusión (F), una proteína de la matriz (M), una fosfoproteína (P), una proteína grande (L) y una proteína de la nucleocápside (N). Además, describe el uso de la composición inmunogénica del invento porque sirve para la fabricación de un medicamento útil en el tratamiento de un sujeto con una infección de virus Hendra.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161485992P | 2011-05-13 | 2011-05-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2013003248A1 true CL2013003248A1 (es) | 2014-08-08 |
Family
ID=47177303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2013003248A CL2013003248A1 (es) | 2011-05-13 | 2013-11-13 | Composición inmunogenica que comprende una glucoproteina g de los virus hendra y nipah y un complejo inmunoestimulante; método para producir una respuesta de anticuerpo neutralizante contra un virus hendra y/o nipah en un sujeto. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20150050305A1 (es) |
| EP (2) | EP2707025B8 (es) |
| JP (4) | JP2014516955A (es) |
| KR (2) | KR20200040899A (es) |
| CN (2) | CN104244974A (es) |
| AU (2) | AU2012256000B2 (es) |
| CA (1) | CA2836098C (es) |
| CL (1) | CL2013003248A1 (es) |
| CO (1) | CO6940373A2 (es) |
| ES (2) | ES2639122T3 (es) |
| MX (2) | MX392320B (es) |
| PH (1) | PH12013502322A1 (es) |
| PT (1) | PT2707025T (es) |
| RU (1) | RU2681529C2 (es) |
| UA (1) | UA114086C2 (es) |
| WO (1) | WO2012158643A1 (es) |
| ZA (1) | ZA201308701B (es) |
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| TWI483950B (zh) | 2009-09-21 | 2015-05-11 | Gilead Sciences Inc | 用於製備１’－取代碳核苷類似物之方法及中間物 |
| PH12013500035A1 (en) | 2010-07-22 | 2013-03-11 | Gilead Sciences Inc | Methods and compounds for treating paramyxoviridae virus infections |
| ES2764079T3 (es) * | 2011-05-27 | 2020-06-02 | Boehringer Ingelheim Animal Health Usa Inc | Vacunas genéticas contra el virus Hendra y el virus Nipah |
| CN109078179A (zh) * | 2013-09-05 | 2018-12-25 | 硕腾服务有限责任公司 | Hendra和Nipah病毒G糖蛋白免疫原性组合物 |
| RU2730011C2 (ru) * | 2013-09-19 | 2020-08-14 | Зоэтис Сервисиз Ллс | Адъюванты на масляной основе |
| EP3082856A1 (en) * | 2013-12-16 | 2016-10-26 | Zoetis Services LLC | Hendra and nipah virus g glycoprotein immunogenic compositions |
| TWI740546B (zh) | 2014-10-29 | 2021-09-21 | 美商基利科學股份有限公司 | 製備核糖苷的方法 |
| SG10202109869XA (en) | 2015-09-16 | 2021-10-28 | Gilead Sciences Inc | Methods for treating arenaviridae and coronaviridae virus infections |
| EP3235908A1 (en) * | 2016-04-21 | 2017-10-25 | Ecole Normale Superieure De Lyon | Methods for selectively modulating the activity of distinct subtypes of cells |
| AR109621A1 (es) * | 2016-10-24 | 2018-12-26 | Janssen Pharmaceuticals Inc | Formulaciones de vacunas contra glucoconjugados de expec |
| CN110869028B (zh) | 2017-03-14 | 2023-01-20 | 吉利德科学公司 | 治疗猫冠状病毒感染的方法 |
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| WO2019014247A1 (en) | 2017-07-11 | 2019-01-17 | Gilead Sciences, Inc. | COMPOSITIONS COMPRISING POLYMERASE RNA INHIBITOR AND CYCLODEXTRIN FOR THE TREATMENT OF VIRAL INFECTIONS |
| AU2018390817B2 (en) * | 2017-12-20 | 2025-06-05 | Zoetis Services Llc | Vaccines against Hendra and Nipah virus infection |
| JP2022513040A (ja) | 2018-11-14 | 2022-02-07 | フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド | コンパートメント特異的カーゴ送達のための組成物および方法 |
| CN110951922A (zh) * | 2019-12-25 | 2020-04-03 | 中国动物卫生与流行病学中心 | 一种检测亨德拉病毒的raa引物探针及检测方法 |
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| US11613553B2 (en) | 2020-03-12 | 2023-03-28 | Gilead Sciences, Inc. | Methods of preparing 1′-cyano nucleosides |
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| KR102897866B1 (ko) * | 2023-12-12 | 2025-12-11 | 대한민국(질병관리청 국립보건연구원장) | 니파바이러스 재조합 g 단백질을 포함하는 백신 조성물 |
| KR102900650B1 (ko) * | 2024-08-01 | 2025-12-19 | 대한민국 | 니파바이러스 g 당단백질 유래 에피토프를 포함하는 펩타이드 및 이를 포함하는 백신 조성물 |
| KR102900618B1 (ko) * | 2024-08-01 | 2025-12-19 | 대한민국 | 니파바이러스 f 당단백질 유래 에피토프를 포함하는 펩타이드 및 이를 포함하는 백신 조성물 |
| KR102864661B1 (ko) * | 2024-12-20 | 2025-09-29 | 대한민국 | 니파바이러스 재조합 단백질을 포함하는 백신 조성물 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8205892D0 (sv) | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
| SE8405493D0 (sv) | 1984-11-01 | 1984-11-01 | Bror Morein | Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel |
| JP2851288B2 (ja) | 1987-06-05 | 1999-01-27 | アメリカ合衆国 | 癌診断および管理における自己分泌運動性因子 |
| NZ230747A (en) | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
| SE9600647D0 (sv) | 1996-02-21 | 1996-02-21 | Bror Morein | Ny användning |
| AUPO517897A0 (en) * | 1997-02-19 | 1997-04-11 | Csl Limited | Chelating immunostimulating complexes |
| GB9817052D0 (en) | 1998-08-05 | 1998-09-30 | Smithkline Beecham Biolog | Vaccine |
| AUPP807399A0 (en) * | 1999-01-08 | 1999-02-04 | Csl Limited | Improved immunogenic lhrh composition and methods relating thereto |
| US20050287170A1 (en) * | 2002-12-11 | 2005-12-29 | Hawaii Biotech, Inc. | Subunit vaccine against West Nile viral infection |
| CN1882704A (zh) * | 2003-09-22 | 2006-12-20 | 巴斯德研究院 | 尼帕病毒检测方法和提供抗汉尼巴病毒的免疫保护的方法 |
| AU2004274717A1 (en) * | 2003-09-22 | 2005-03-31 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | A method for detecting Nipah virus and method for providing immunoprotection against henipaviruses |
| ES2673972T3 (es) * | 2004-07-09 | 2018-06-26 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Formas solubles de la glicoproteína G de los virus hendra y nipah |
| DE602005027258D1 (de) | 2005-03-14 | 2011-05-12 | Us Gov Health & Human Serv | Humane monoklonale antikörper gegen hendra- und nipah-viren |
| WO2006115843A2 (en) * | 2005-04-25 | 2006-11-02 | Merial Limited | Nipah virus vaccines |
| EP3118213A1 (en) | 2007-12-19 | 2017-01-18 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | Soluble forms of hendra and nipah virus f glycoprotein and uses thereof |
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