UA114086C2 - Імуногенна композиція глікопротеїну g вірусу hendra і/або nipah - Google Patents

Імуногенна композиція глікопротеїну g вірусу hendra і/або nipah

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UA114086C2
UA114086C2 UAA201314534A UAA201314534A UA114086C2 UA 114086 C2 UA114086 C2 UA 114086C2 UA A201314534 A UAA201314534 A UA A201314534A UA A201314534 A UAA201314534 A UA A201314534A UA 114086 C2 UA114086 C2 UA 114086C2
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hendra
nipah
glycoprotein
immmunogenic
composition
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UAA201314534A
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/155Paramyxoviridae, e.g. parainfluenza virus
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
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    • C12N2760/18011Paramyxoviridae
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    • G01N2469/00Immunoassays for the detection of microorganisms
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  • Health & Medical Sciences (AREA)
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Abstract

Винахід стосується вакцини, що містить глікопротеїн G вірусу Hendra і/або Nipah у кількості 5-100 мкг/дозу, імуностимулюючий комплекс (ISC), який містить сапонін та стероїд, і один або більше ексципієнтів, у кількості, здатній ефективно викликати імунологічний захист проти вірусів Hendra і/або Nipah після введення суб'єкту, який сприйнятливий до вірусу Hendra і/або Nipah, де вказаний суб'єкт являє собою коня або свиню.
UAA201314534A 2011-05-13 2012-05-14 Імуногенна композиція глікопротеїну g вірусу hendra і/або nipah UA114086C2 (xx)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161485992P 2011-05-13 2011-05-13
PCT/US2012/037839 WO2012158643A1 (en) 2011-05-13 2012-05-14 Hendra and nipah virus g glycoprotein immunogenic compositions

Publications (1)

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UA114086C2 true UA114086C2 (xx) 2017-04-25

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US (1) US20150050305A1 (uk)
EP (2) EP3251692B1 (uk)
JP (4) JP2014516955A (uk)
KR (2) KR20140053906A (uk)
CN (2) CN104244974A (uk)
AU (2) AU2012256000B2 (uk)
BR (1) BR112013029309A8 (uk)
CA (1) CA2836098C (uk)
CL (1) CL2013003248A1 (uk)
CO (1) CO6940373A2 (uk)
ES (2) ES2639122T3 (uk)
HK (1) HK1247833A1 (uk)
MX (1) MX352604B (uk)
PT (1) PT2707025T (uk)
RU (1) RU2681529C2 (uk)
UA (1) UA114086C2 (uk)
WO (1) WO2012158643A1 (uk)
ZA (1) ZA201308701B (uk)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2480559E (pt) 2009-09-21 2013-10-02 Gilead Sciences Inc Processos e intermediários para a preparação de análogos de 1'-ciano-carbanucleósido
UA111163C2 (uk) 2010-07-22 2016-04-11 Гайлід Сайєнсіз, Інк. Способи й сполуки для лікування вірусних інфекцій paramyxoviridae
CA2837582C (en) * 2011-05-27 2021-03-02 Merial Limited Genetic vaccines against hendra virus and nipah virus
WO2015034903A1 (en) * 2013-09-05 2015-03-12 Zoetis Llc Hendra and nipah virus g glycoprotein immunogenic compositions
KR20200039025A (ko) * 2013-09-19 2020-04-14 조에티스 서비시즈 엘엘씨 유성 아쥬반트
EP3082856A1 (en) * 2013-12-16 2016-10-26 Zoetis Services LLC Hendra and nipah virus g glycoprotein immunogenic compositions
TWI740546B (zh) 2014-10-29 2021-09-21 美商基利科學股份有限公司 製備核糖苷的方法
EP3785717B1 (en) 2015-09-16 2022-01-05 Gilead Sciences, Inc. Methods for treating coronaviridae infections
AR109621A1 (es) * 2016-10-24 2018-12-26 Janssen Pharmaceuticals Inc Formulaciones de vacunas contra glucoconjugados de expec
ES2961460T3 (es) 2017-03-14 2024-03-12 Gilead Sciences Inc Métodos para tratar las infecciones por coronavirus felinas
CN108624602B (zh) * 2017-03-24 2020-10-16 华中农业大学 一株具有阻断活性的抗尼帕病毒g蛋白的单克隆抗体及其应用
WO2018204198A1 (en) 2017-05-01 2018-11-08 Gilead Sciences, Inc. Crystalline forms of (s) 2 ethylbutyl 2 (((s) (((2r,3s,4r,5r) 5 (4 aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2 yl)methoxy)(phenoxy) phosphoryl)amino)propanoate
US10675296B2 (en) 2017-07-11 2020-06-09 Gilead Sciences, Inc. Compositions comprising an RNA polymerase inhibitor and cyclodextrin for treating viral infections
JP7370983B2 (ja) * 2017-12-20 2023-10-30 ゾエティス・サービシーズ・エルエルシー ヘンドラウイルス感染症及びニパウイルス感染症に対するワクチン
CN110951922A (zh) * 2019-12-25 2020-04-03 中国动物卫生与流行病学中心 一种检测亨德拉病毒的raa引物探针及检测方法
US11660307B2 (en) 2020-01-27 2023-05-30 Gilead Sciences, Inc. Methods for treating SARS CoV-2 infections
WO2021183750A2 (en) 2020-03-12 2021-09-16 Gilead Sciences, Inc. Methods of preparing 1'-cyano nucleosides
WO2021207049A1 (en) 2020-04-06 2021-10-14 Gilead Sciences, Inc. Inhalation formulations of 1'-cyano substituted carbanucleoside analogs
EP4157272A1 (en) 2020-05-29 2023-04-05 Gilead Sciences, Inc. Remdesivir treatment methods
MX2022016405A (es) 2020-06-24 2023-01-30 Gilead Sciences Inc Análogos de nucleósido de 1¿-ciano y usos de estos.
JP2023540225A (ja) 2020-08-27 2023-09-22 ギリアード サイエンシーズ, インコーポレイテッド ウイルス感染症の治療のための化合物及び方法
US20220193225A1 (en) * 2020-08-31 2022-06-23 Bruce Lyday Compositions and methods for sars-2 vaccine with virus replicative particles and recombinant glycoproteins
WO2022270656A1 (ko) * 2021-06-24 2022-12-29 진철 금 나노입자를 유효성분으로 포함하는 니파 바이러스의 예방 또는 치료용 조성물
TW202400185A (zh) 2022-03-02 2024-01-01 美商基利科學股份有限公司 用於治療病毒感染的化合物及方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8205892D0 (sv) 1982-10-18 1982-10-18 Bror Morein Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
SE8405493D0 (sv) 1984-11-01 1984-11-01 Bror Morein Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel
WO1988009797A1 (en) 1987-06-05 1988-12-15 The United States Of America, As Represented By Th Autocrine motility factors in cancer diagnosis and management
NZ230747A (en) 1988-09-30 1992-05-26 Bror Morein Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina
SE9600647D0 (sv) 1996-02-21 1996-02-21 Bror Morein Ny användning
AUPO517897A0 (en) * 1997-02-19 1997-04-11 Csl Limited Chelating immunostimulating complexes
GB9817052D0 (en) 1998-08-05 1998-09-30 Smithkline Beecham Biolog Vaccine
AUPP807399A0 (en) * 1999-01-08 1999-02-04 Csl Limited Improved immunogenic lhrh composition and methods relating thereto
US20050287170A1 (en) * 2002-12-11 2005-12-29 Hawaii Biotech, Inc. Subunit vaccine against West Nile viral infection
JP2007505618A (ja) * 2003-09-22 2007-03-15 インスティティ・パスツール ニパウイルスの検出方法及びヘニパウイルスに対する免疫保護を提供する方法
CN1882704A (zh) * 2003-09-22 2006-12-20 巴斯德研究院 尼帕病毒检测方法和提供抗汉尼巴病毒的免疫保护的方法
AU2005327194B2 (en) * 2004-07-09 2010-09-09 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Soluble forms of Hendra and Nipah virus G glycoprotein
EP1861424B1 (en) 2005-03-14 2011-03-30 The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services Human monoclonal antibodies against hendra and nipah viruses
CN101208104B (zh) * 2005-04-25 2012-10-31 梅瑞尔有限公司 Nipah病毒疫苗
WO2009117035A1 (en) 2007-12-19 2009-09-24 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Soluble forms of hendra and nipah virus f glycoprotein and uses thereof

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US20150050305A1 (en) 2015-02-19
CA2836098A1 (en) 2012-11-22
EP2707025A1 (en) 2014-03-19
JP2014516955A (ja) 2014-07-17
KR20140053906A (ko) 2014-05-08
PT2707025T (pt) 2017-08-31
MX352604B (es) 2017-11-30
ES2963147T3 (es) 2024-03-25
AU2017213501A1 (en) 2017-08-31
EP2707025B8 (en) 2017-08-23
JP2017193537A (ja) 2017-10-26
RU2019104307A (ru) 2019-04-15
JP2018030862A (ja) 2018-03-01
MX2013013277A (es) 2014-09-22
ES2639122T3 (es) 2017-10-25
AU2012256000A1 (en) 2013-12-12
CO6940373A2 (es) 2014-05-09
WO2012158643A1 (en) 2012-11-22
CN104244974A (zh) 2014-12-24
CN110680913A (zh) 2020-01-14
CA2836098C (en) 2022-06-21
RU2681529C2 (ru) 2019-03-07
EP3251692B1 (en) 2023-09-27
JP6898024B2 (ja) 2021-07-07
EP2707025B1 (en) 2017-07-12
AU2012256000B2 (en) 2017-05-11
EP3251692A1 (en) 2017-12-06
BR112013029309A8 (pt) 2018-01-23
EP2707025A4 (en) 2014-12-17
KR20200040899A (ko) 2020-04-20
BR112013029309A2 (pt) 2017-06-20
JP2019142909A (ja) 2019-08-29
NZ617722A (en) 2016-03-31
CL2013003248A1 (es) 2014-08-08
RU2013155470A (ru) 2015-06-20
ZA201308701B (en) 2015-08-26
HK1247833A1 (zh) 2018-10-05

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