RU2019104307A - Иммуногенные композиции гликопротеина g вирусов hendra и nipah - Google Patents
Иммуногенные композиции гликопротеина g вирусов hendra и nipah Download PDFInfo
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- RU2019104307A RU2019104307A RU2019104307A RU2019104307A RU2019104307A RU 2019104307 A RU2019104307 A RU 2019104307A RU 2019104307 A RU2019104307 A RU 2019104307A RU 2019104307 A RU2019104307 A RU 2019104307A RU 2019104307 A RU2019104307 A RU 2019104307A
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- 108010046722 Thrombospondin 1 Proteins 0.000 title claims 5
- 102100036034 Thrombospondin-1 Human genes 0.000 title claims 5
- 241000700605 Viruses Species 0.000 title claims 3
- 239000000203 mixture Substances 0.000 title claims 2
- 230000002163 immunogen Effects 0.000 title 1
- 229960005486 vaccine Drugs 0.000 claims 11
- 241000526636 Nipah henipavirus Species 0.000 claims 7
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 4
- 241000893570 Hendra henipavirus Species 0.000 claims 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 150000003905 phosphatidylinositols Chemical class 0.000 claims 3
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 2
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims 2
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 2
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 2
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims 2
- SUHOOTKUPISOBE-UHFFFAOYSA-N O-phosphoethanolamine Chemical compound NCCOP(O)(O)=O SUHOOTKUPISOBE-UHFFFAOYSA-N 0.000 claims 2
- UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 claims 2
- 229940106189 ceramide Drugs 0.000 claims 2
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims 2
- 235000012000 cholesterol Nutrition 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 2
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 2
- 150000003908 phosphatidylinositol bisphosphates Chemical class 0.000 claims 2
- 150000003907 phosphatidylinositol monophosphates Chemical class 0.000 claims 2
- 150000003904 phospholipids Chemical class 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims 2
- 229930182490 saponin Natural products 0.000 claims 2
- 150000007949 saponins Chemical class 0.000 claims 2
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims 1
- 108060003393 Granulin Proteins 0.000 claims 1
- 108090001074 Nucleocapsid Proteins Proteins 0.000 claims 1
- 102000007982 Phosphoproteins Human genes 0.000 claims 1
- 108010089430 Phosphoproteins Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000008103 phosphatidic acids Chemical class 0.000 claims 1
- YHHSONZFOIEMCP-UHFFFAOYSA-O phosphocholine Chemical compound C[N+](C)(C)CCOP(O)(O)=O YHHSONZFOIEMCP-UHFFFAOYSA-O 0.000 claims 1
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims 1
- 229950004354 phosphorylcholine Drugs 0.000 claims 1
- 239000001226 triphosphate Substances 0.000 claims 1
- 235000011178 triphosphate Nutrition 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
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Claims (15)
1. Вакцина для предотвращения инфекции, вызванной вирусом Hendra и/или Nipah, у лошади или свиньи, содержащая
а. 50-100 мкг растворимого фрагмента гликопротеина G вируса Nipah, при этом указанный фрагмент состоит из аминокислот 71-602 SEQ ID NO: 4 или последовательности, по меньшей мере на 95% ей идентичной,
b. иммуностимулирующий комплекс (ISC), при этом ISC содержит сапонин, фосфолипид, выбранный из группы, состоящей из фосфатидилхолина (PC), дипальмитоилфосфатидилхолина (DPPC), фосфатидиновой кислоты (фосфатидат) (PA), фосфатидилэтаноламина (PE), фосфатидилсерина (PS), фосфатидилинозита (PI) фосфатидилинозитфосфата (PIP), фосфатидилинозитбисфосфата (PIP2), фосфатидилинозиттрифосфата (PIP3), фосфорилхолина (SPH), церамидфосфорилэтаноламина (Cer-PE) и церамидфосфорилглицерина, и холестерин, и
с. один или более эксципиентов.
2. Вакцина по п. 1, где вакцина содержит 100 мкг указанного растворимого фрагмента гликопротеина G вируса Nipah.
3. Вакцина по п.1 или 2, где растворимый гликопротеин G вируса Nipah присутствует в димерной форме.
4. Вакцина по п.1 или 2, где растворимый гликопротеин G вируса Nipah присутствует в форме тетрамера.
5. Вакцина по любому из пп. 1-4, где вакцина содержит 250 мкг ISC.
6. Вакцина по любому из пп.1-5, где указанный сапонин представляет собой Quil A, и указанный фосфолипид представляет собой DPPC.
7. Вакцина по п.6, где отношение Quil A:DPPC:холестерин в композиции составляет 5:1:1 по массе.
8. Способ предотвращения инфекции, вызванной вирусом Hendra и/или Nipah, у лошади или свиньи, включающий введение первой дозы и второй дозы вакцины по любому из пп. 1-7.
9. Способ по п.8, где вторую дозу вводят через около 21-28 дней после первой дозы.
10. Способ дифференциации субъекта, вакцинированного вакциной по любому из пп.1-7, от субъекта, подвергнутого воздействию вируса Hendra и/или Nipah, включающий детектирование присутствие антитела в биологическом образце, выделенном из субъекта, против по меньшей мере любого одного из следующих вирусных белков HeV и/или NiV, выбранных из группы, состоящей из слитого белка (F), матриксного белка (M), фосфопротеина (P), крупного белка (L) и нуклеокапсидного белка (N), где субъектом является лошадь или свинья.
11. Способ по п.10, где указанный вирус представляет собой вирус Hendra, и субъект представляет собой лошадь.
12. Способ по п.10, где указанный вирус представляет собой вирус Nipah, и субъект представляет собой свинью.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161485992P | 2011-05-13 | 2011-05-13 | |
| US61/485,992 | 2011-05-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013155470A Division RU2681529C2 (ru) | 2011-05-13 | 2012-05-14 | Иммуногенные композиции гликопротеина g вирусов hendra и nipah |
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| Publication Number | Publication Date |
|---|---|
| RU2019104307A true RU2019104307A (ru) | 2019-04-15 |
| RU2787820C2 RU2787820C2 (ru) | 2023-01-12 |
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