CL2008003598A1 - Procedimiento de preparacion de 3-z-[1-(4-(n-((4-metil-piperazina-1-il)-metilcarbonil)-n-metil-amino)-anilino)-1-fenil-metilen]-6-metoxicarbonil-2-indolinona por descloroacetilacion en medio basico de uno de los compuestos intermediarios. - Google Patents

Procedimiento de preparacion de 3-z-[1-(4-(n-((4-metil-piperazina-1-il)-metilcarbonil)-n-metil-amino)-anilino)-1-fenil-metilen]-6-metoxicarbonil-2-indolinona por descloroacetilacion en medio basico de uno de los compuestos intermediarios.

Info

Publication number
CL2008003598A1
CL2008003598A1 CL2008003598A CL2008003598A CL2008003598A1 CL 2008003598 A1 CL2008003598 A1 CL 2008003598A1 CL 2008003598 A CL2008003598 A CL 2008003598A CL 2008003598 A CL2008003598 A CL 2008003598A CL 2008003598 A1 CL2008003598 A1 CL 2008003598A1
Authority
CL
Chile
Prior art keywords
methyl
phenyl
indolinone
methylcarbonyl
anilino
Prior art date
Application number
CL2008003598A
Other languages
English (en)
Inventor
Guenter Linz
Rolf Schmid
Werner Rall
Carsten Reichel
J Schnaubelt
Joern Merten
Svenja Renner
Robert Schiffers
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CL2008003598A1 publication Critical patent/CL2008003598A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedimiento de preparación de 3-z-[1-(4-(n-((4-metil-piperazina-1-il)-metilcarbonil)-n-metil-amino)-anilino)-1-fenil-metilen]-6-metoxicarbonil-2-indolinona, a partir de metil-3-[metoxi(fenil)metiliden]-2-oxo-2,3-diidro-1h-indol-6-carboxilato y n-(4-aminofenil)-n-metil-2-(4-metilpiperazin-1-il)acetamida.
CL2008003598A 2007-12-03 2008-12-02 Procedimiento de preparacion de 3-z-[1-(4-(n-((4-metil-piperazina-1-il)-metilcarbonil)-n-metil-amino)-anilino)-1-fenil-metilen]-6-metoxicarbonil-2-indolinona por descloroacetilacion en medio basico de uno de los compuestos intermediarios. CL2008003598A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07122122 2007-12-03

Publications (1)

Publication Number Publication Date
CL2008003598A1 true CL2008003598A1 (es) 2010-02-12

Family

ID=40452557

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008003598A CL2008003598A1 (es) 2007-12-03 2008-12-02 Procedimiento de preparacion de 3-z-[1-(4-(n-((4-metil-piperazina-1-il)-metilcarbonil)-n-metil-amino)-anilino)-1-fenil-metilen]-6-metoxicarbonil-2-indolinona por descloroacetilacion en medio basico de uno de los compuestos intermediarios.

Country Status (21)

Country Link
US (1) US8304541B2 (es)
EP (1) EP2229359B1 (es)
JP (1) JP5269907B2 (es)
KR (1) KR20100094497A (es)
CN (1) CN101883756A (es)
AR (1) AR069530A1 (es)
AU (1) AU2008333286B2 (es)
BR (1) BRPI0820689A2 (es)
CA (1) CA2706423A1 (es)
CL (1) CL2008003598A1 (es)
DK (1) DK2229359T3 (es)
ES (1) ES2658091T3 (es)
HU (1) HUE036390T2 (es)
IL (1) IL205389A (es)
MX (1) MX2010005556A (es)
NZ (1) NZ585799A (es)
PL (1) PL2229359T3 (es)
RU (1) RU2525114C2 (es)
TR (1) TR201802086T4 (es)
TW (1) TWI432424B (es)
WO (1) WO2009071523A1 (es)

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UY31506A1 (es) * 2007-12-03 2009-08-03 Derivados de indolinona y procedimiento para su preparacion
US20170065529A1 (en) 2015-09-09 2017-03-09 Boehringer Ingelheim International Gmbh Pharmaceutical dosage form for immediate release of an indolinone derivative
WO2012068441A2 (en) 2010-11-19 2012-05-24 Ratiopharm Gmbh Intedanib salts and solid state forms thereof
US20140350022A1 (en) 2013-05-10 2014-11-27 Boehringer Ingelheim International Gmbh Efficacious treatment of NSCLC and predictive clinical marker of the responsiveness of a tumour to a treatment
CN104829596B (zh) * 2014-02-10 2017-02-01 石家庄以岭药业股份有限公司 吡咯取代吲哚酮类衍生物、其制备方法、包含该衍生物的组合物、及其用途
CN104262232B (zh) 2014-09-09 2016-05-04 苏州明锐医药科技有限公司 尼泰达尼的制备方法
CN106008308A (zh) * 2015-03-13 2016-10-12 正大天晴药业集团股份有限公司 尼达尼布乙磺酸盐结晶
WO2016178064A1 (en) * 2015-05-06 2016-11-10 Suven Life Sciences Limited Polymorph of nintedanib ethanesulphonate, processes and intermediates thereof
CN104844499B (zh) * 2015-06-05 2017-03-08 北京康立生医药技术开发有限公司 一锅法制备尼达尼布的合成方法
CN105126909B (zh) * 2015-07-13 2018-01-23 淮海工学院 固载钯催化剂在4‑苯乙炔基‑3‑硝基苯甲酸甲酯合成中的应用
CN105001143A (zh) * 2015-07-24 2015-10-28 南京正大天晴制药有限公司 一种制备高纯度乙磺酸尼达尼布的方法
CZ308695B6 (cs) 2015-07-29 2021-03-03 Zentiva, K.S. Způsob přípravy methyl (Z)-3[[4-[methyl[2-(4-methyl-1piperazinyl)acetyl]amino]fenyl]amino]fenylmethylen)-oxindol-6karboxylátu (intedanibu, nintedanibu)
CN106432042A (zh) * 2015-08-13 2017-02-22 南京华威医药科技开发有限公司 尼达尼布乙磺酸水合物的药物新晶型
CN106467500A (zh) * 2015-08-14 2017-03-01 廊坊百瑞化工有限公司 一种一锅煮法合成尼达尼布关键中间体的新方法
WO2017077551A2 (en) * 2015-11-03 2017-05-11 Mylan Laboratories Limited An amorphous nintedanib esylate and solid dispersion thereof
CN105418483A (zh) * 2015-12-15 2016-03-23 南京艾德凯腾生物医药有限责任公司 一种结晶型乙磺酸尼达尼布的制备方法
CN105461609B (zh) * 2015-12-25 2019-08-23 杭州新博思生物医药有限公司 一种尼达尼布的制备方法
CN105837493B (zh) * 2016-04-08 2018-12-14 东南大学 尼达尼布的合成方法及其中间体
CN109415314A (zh) * 2016-05-19 2019-03-01 上海诚妙医药科技有限公司 尼达尼布的新晶型及其制备方法及其用途
CN106543069A (zh) * 2016-09-20 2017-03-29 北京万全德众医药生物技术有限公司 6‑甲氧基羰基‑2‑氧代二氢吲哚的制备
CN107935909B (zh) * 2016-10-13 2023-03-17 上海科胜药物研发有限公司 一种尼达尼布（nintedanib）及其中间体的合成方法
WO2018068733A1 (zh) * 2016-10-12 2018-04-19 浙江华海药业股份有限公司 尼达尼布及其中间体的制备方法
CN108610308A (zh) * 2016-12-09 2018-10-02 上海奥博生物医药技术有限公司 一锅法制备尼达尼布中间体的方法
WO2018165865A1 (zh) * 2017-03-14 2018-09-20 新源生物科技股份有限公司 3-z-[1-(4-(n-((4-甲基-哌嗪-1-基)-甲羰基)-n-甲基-氨基)-苯氨基)-1-苯基-亚甲基]-6-甲氧羰基-2-吲哚满酮的晶型
CN106841495B (zh) * 2017-04-21 2018-05-11 常州佳德医药科技有限公司 乙磺酸尼达尼布中基因毒性杂质的高灵敏度分析方法
EP3710427B1 (en) 2017-11-17 2023-03-08 Fermion Oy Synthesis of a 2-indolinone derivative known as intermediate for preparing nintedanib
CN110746378B (zh) * 2018-12-03 2021-11-05 江苏豪森药业集团有限公司 一种胺基中间体的制备方法
CN111004141B (zh) * 2019-12-19 2022-10-04 苏州诚和医药化学有限公司 一种尼达尼布中间体2-氯-n-甲基-n-(4-硝基苯基)乙酰胺合成新方法
CN115181078A (zh) * 2022-07-27 2022-10-14 安徽修一制药有限公司 一种尼达尼布关键中间体的合成方法

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SI1115704T1 (en) 1998-09-25 2003-12-31 Boehringer Ingelheim Pharma Gmbh & Co. Kg Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes
UA75054C2 (uk) * 1999-10-13 2006-03-15 Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу
DE10233500A1 (de) * 2002-07-24 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel
US7148249B2 (en) 2002-09-12 2006-12-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments

Also Published As

Publication number Publication date
EP2229359A1 (en) 2010-09-22
KR20100094497A (ko) 2010-08-26
MX2010005556A (es) 2010-08-11
AU2008333286B2 (en) 2014-08-14
RU2010126906A (ru) 2012-01-10
JP2011504919A (ja) 2011-02-17
HUE036390T2 (hu) 2018-07-30
ES2658091T3 (es) 2018-03-08
WO2009071523A1 (en) 2009-06-11
AR069530A1 (es) 2010-01-27
US20110201812A1 (en) 2011-08-18
US8304541B2 (en) 2012-11-06
IL205389A (en) 2014-11-30
DK2229359T3 (en) 2018-02-05
EP2229359B1 (en) 2017-11-29
TWI432424B (zh) 2014-04-01
BRPI0820689A2 (pt) 2019-09-24
IL205389A0 (en) 2010-12-30
CA2706423A1 (en) 2009-06-11
TR201802086T4 (tr) 2018-03-21
TW200932739A (en) 2009-08-01
RU2525114C2 (ru) 2014-08-10
AU2008333286A1 (en) 2009-06-11
NZ585799A (en) 2012-04-27
JP5269907B2 (ja) 2013-08-21
CN101883756A (zh) 2010-11-10
PL2229359T3 (pl) 2018-04-30

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