CL2008002982A1 - Compuestos derivados de 4,5-difenil-imidazol sustituidos por heterociclos, inhibidores mdm2; composicion farmaceutica que los comprende; proceso de preparacion de los compuestos; y uso en el tratamiento del cancer de mama, colon, pulmon o prostata. - Google Patents
Compuestos derivados de 4,5-difenil-imidazol sustituidos por heterociclos, inhibidores mdm2; composicion farmaceutica que los comprende; proceso de preparacion de los compuestos; y uso en el tratamiento del cancer de mama, colon, pulmon o prostata.Info
- Publication number
- CL2008002982A1 CL2008002982A1 CL2008002982A CL2008002982A CL2008002982A1 CL 2008002982 A1 CL2008002982 A1 CL 2008002982A1 CL 2008002982 A CL2008002982 A CL 2008002982A CL 2008002982 A CL2008002982 A CL 2008002982A CL 2008002982 A1 CL2008002982 A1 CL 2008002982A1
- Authority
- CL
- Chile
- Prior art keywords
- heterocycle
- colon
- diphenyl
- breast
- lung
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Abstract
Compuestos derivados de 4,5-difenil-imidazol sustituidos por heterociclos; procedimiento de preparación; composición farmacéutica que comprende dichos compuestos; y su uso en el tratamiento del cáncer, tal como, cáncer de mama, colon, pulmón y próstata.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97850607P | 2007-10-09 | 2007-10-09 | |
US9275908P | 2008-08-29 | 2008-08-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2008002982A1 true CL2008002982A1 (es) | 2009-10-16 |
Family
ID=40149549
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2008002982A CL2008002982A1 (es) | 2007-10-09 | 2008-10-07 | Compuestos derivados de 4,5-difenil-imidazol sustituidos por heterociclos, inhibidores mdm2; composicion farmaceutica que los comprende; proceso de preparacion de los compuestos; y uso en el tratamiento del cancer de mama, colon, pulmon o prostata. |
Country Status (20)
Country | Link |
---|---|
US (1) | US8513239B2 (es) |
EP (2) | EP2203437B1 (es) |
JP (1) | JP5324586B2 (es) |
KR (1) | KR101203020B1 (es) |
CN (2) | CN104710408A (es) |
AR (1) | AR068742A1 (es) |
AU (1) | AU2008309759A1 (es) |
BR (1) | BRPI0817850A2 (es) |
CA (1) | CA2701932C (es) |
CL (1) | CL2008002982A1 (es) |
CO (1) | CO6280486A2 (es) |
CR (1) | CR11333A (es) |
ES (1) | ES2395210T3 (es) |
IL (1) | IL204653A0 (es) |
MA (1) | MA31754B1 (es) |
MX (1) | MX2010003868A (es) |
PE (1) | PE20090814A1 (es) |
RU (1) | RU2487127C2 (es) |
TW (1) | TW200916446A (es) |
WO (1) | WO2009047161A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2375899B1 (en) * | 2009-01-12 | 2015-02-25 | Array Biopharma Inc. | Piperidine-containing compounds and use thereof in the treatment of diabetes |
US8389731B2 (en) * | 2009-05-15 | 2013-03-05 | Northwestern University | Chiral pyrrolidine core compounds en route to inhibitors of nitric oxide synthase |
JP5658272B2 (ja) | 2009-12-17 | 2015-01-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ccr2の新規アンタゴニスト及びこれらの使用 |
PT3091012T (pt) | 2009-12-17 | 2018-06-27 | Centrexion Therapeutics Corp | Antagonistas do receptor ccr2 e suas utilizações |
JP2013526507A (ja) | 2010-05-12 | 2013-06-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ccr2受容体アンタゴニスト、その製造方法及び薬物としてのその使用 |
JP5636094B2 (ja) | 2010-05-25 | 2014-12-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ccr2受容体アンタゴニスト |
EP2576538B1 (en) | 2010-06-01 | 2015-10-28 | Boehringer Ingelheim International GmbH | New CCR2 antagonists |
JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
CA2813256A1 (en) | 2010-09-30 | 2012-04-05 | St. Jude Children's Research Hospital | Aryl-substituted imidazoles |
WO2012080389A1 (en) | 2010-12-16 | 2012-06-21 | Roche Glycart Ag | Combination therapy of an afucosylated cd20 antibody with a mdm2 inhibitor |
CA2850166C (en) | 2011-09-27 | 2019-12-03 | Amgen Inc. | Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer |
WO2014082889A1 (en) * | 2012-11-28 | 2014-06-05 | F. Hoffmann-La Roche Ag | Novel imidazolines as dual inhibitors of mdm2 and mdmx |
CA2895504A1 (en) | 2012-12-20 | 2014-06-26 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as hdm2 inhibitors |
US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
MX368703B (es) | 2013-02-28 | 2019-10-11 | Amgen Inc | Un inhibidor de mdm2 derivado de acido benzoico para el tratamiento del cancer. |
RU2737434C2 (ru) | 2013-03-13 | 2020-11-30 | Форма Терапьютикс, Инк. | Новые соединения и композиции для ингибирования fasn |
WO2014151863A1 (en) | 2013-03-14 | 2014-09-25 | Amgen Inc. | Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer |
JOP20200296A1 (ar) | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
US10758525B2 (en) | 2015-01-22 | 2020-09-01 | MyoKardia, Inc. | 4-methylsulfonyl-substituted piperidine urea compounds |
PL3458101T3 (pl) | 2016-05-20 | 2021-05-31 | F. Hoffmann-La Roche Ag | Koniugaty PROTAC-przeciwciało i sposoby ich stosowania |
CN105906610B (zh) * | 2016-05-24 | 2018-10-23 | 绍兴文理学院 | 一种3-(4-苯基-1h-咪唑-5-基)-1h-吲哚衍生物及其制备方法和应用 |
PL3415802T3 (pl) | 2017-06-14 | 2020-03-31 | Borealis Ag | Dylatacja |
US10793554B2 (en) | 2018-10-29 | 2020-10-06 | Forma Therapeutics, Inc. | Solid forms of 4-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone |
WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02101065A (ja) | 1988-10-06 | 1990-04-12 | Tanabe Seiyaku Co Ltd | イミダゾリン誘導体及びその製法 |
GB2351082A (en) | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Synthesis of Cyclic Substituted Amidines |
EP1463501B1 (en) * | 2001-12-18 | 2008-06-11 | F. Hoffmann-La Roche AG | Cis-imidazolines as mdm2 inhibitors |
JP4477351B2 (ja) | 2001-12-18 | 2010-06-09 | エフ.ホフマン−ラ ロシュ アーゲー | シス−2,4,5−トリフェニル−イミダゾリン類及び腫瘍の処理へのそれらの使用 |
ATE414693T1 (de) | 2004-05-18 | 2008-12-15 | Hoffmann La Roche | Neuartige cis-imidazoline |
ES2377752T5 (es) | 2005-07-08 | 2016-03-14 | Vestas Wind Systems A/S | Turbina eólica, buje para turbina eólica y uso del mismo |
EP2130822A1 (en) * | 2005-12-01 | 2009-12-09 | F. Hoffmann-La Roche AG | 2,4,5-triphenyl imidazoline derivatives as inhibitors of the interaction between p53 and mdm2 proteins for use as anticancer agents |
CN101370799B (zh) * | 2006-01-18 | 2012-09-05 | 霍夫曼-拉罗奇有限公司 | 作为mdm2抑制剂的顺-4,5-二芳基-2-杂环-咪唑啉 |
-
2008
- 2008-09-30 CN CN201510024021.1A patent/CN104710408A/zh active Pending
- 2008-09-30 CA CA2701932A patent/CA2701932C/en active Active
- 2008-09-30 EP EP08837881A patent/EP2203437B1/en active Active
- 2008-09-30 WO PCT/EP2008/063053 patent/WO2009047161A1/en active Application Filing
- 2008-09-30 JP JP2010528361A patent/JP5324586B2/ja not_active Expired - Fee Related
- 2008-09-30 ES ES08837881T patent/ES2395210T3/es active Active
- 2008-09-30 EP EP10175975A patent/EP2325180A1/en not_active Withdrawn
- 2008-09-30 BR BRPI0817850 patent/BRPI0817850A2/pt not_active Application Discontinuation
- 2008-09-30 MX MX2010003868A patent/MX2010003868A/es active IP Right Grant
- 2008-09-30 CN CN200880110704A patent/CN101821251A/zh active Pending
- 2008-09-30 AU AU2008309759A patent/AU2008309759A1/en not_active Abandoned
- 2008-09-30 KR KR1020107007374A patent/KR101203020B1/ko active IP Right Grant
- 2008-09-30 RU RU2010118018/04A patent/RU2487127C2/ru active
- 2008-10-07 AR ARP080104381A patent/AR068742A1/es not_active Application Discontinuation
- 2008-10-07 PE PE2008001740A patent/PE20090814A1/es not_active Application Discontinuation
- 2008-10-07 CL CL2008002982A patent/CL2008002982A1/es unknown
- 2008-10-08 TW TW097138773A patent/TW200916446A/zh unknown
- 2008-10-09 US US12/248,095 patent/US8513239B2/en active Active
-
2010
- 2010-03-22 IL IL204653A patent/IL204653A0/en unknown
- 2010-03-24 CR CR11333A patent/CR11333A/es not_active Application Discontinuation
- 2010-03-26 CO CO10036293A patent/CO6280486A2/es not_active Application Discontinuation
- 2010-04-05 MA MA32739A patent/MA31754B1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
IL204653A0 (en) | 2010-11-30 |
BRPI0817850A2 (pt) | 2015-04-07 |
RU2487127C2 (ru) | 2013-07-10 |
ES2395210T3 (es) | 2013-02-11 |
TW200916446A (en) | 2009-04-16 |
CN104710408A (zh) | 2015-06-17 |
MX2010003868A (es) | 2010-04-27 |
KR20100051742A (ko) | 2010-05-17 |
CO6280486A2 (es) | 2011-05-20 |
JP5324586B2 (ja) | 2013-10-23 |
EP2203437B1 (en) | 2012-11-07 |
PE20090814A1 (es) | 2009-06-27 |
EP2325180A1 (en) | 2011-05-25 |
KR101203020B1 (ko) | 2012-11-20 |
RU2010118018A (ru) | 2011-11-20 |
CA2701932C (en) | 2015-10-20 |
CN101821251A (zh) | 2010-09-01 |
US8513239B2 (en) | 2013-08-20 |
MA31754B1 (fr) | 2010-10-01 |
CA2701932A1 (en) | 2009-04-16 |
JP2010540675A (ja) | 2010-12-24 |
US20090111789A1 (en) | 2009-04-30 |
CR11333A (es) | 2010-06-21 |
AU2008309759A1 (en) | 2009-04-16 |
EP2203437A1 (en) | 2010-07-07 |
AR068742A1 (es) | 2009-12-02 |
WO2009047161A1 (en) | 2009-04-16 |
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