CL2003002042A1 - Compuestos derivados de 3,9-diazabiciclo[3.3.1]noneno; composicion farmaceutica; y uso del compuesto como inhibidor de renina (ras), para tratar hipertension, insuficiencia cardiaca congestiva, hipertension pulmonar, insuficiencia renal, ateroscleros - Google Patents

Compuestos derivados de 3,9-diazabiciclo[3.3.1]noneno; composicion farmaceutica; y uso del compuesto como inhibidor de renina (ras), para tratar hipertension, insuficiencia cardiaca congestiva, hipertension pulmonar, insuficiencia renal, ateroscleros

Info

Publication number
CL2003002042A1
CL2003002042A1 CL200302042A CL2003002042A CL2003002042A1 CL 2003002042 A1 CL2003002042 A1 CL 2003002042A1 CL 200302042 A CL200302042 A CL 200302042A CL 2003002042 A CL2003002042 A CL 2003002042A CL 2003002042 A1 CL2003002042 A1 CL 2003002042A1
Authority
CL
Chile
Prior art keywords
nonene
hypertension
ateroscleros
diazabiciclo
ras
Prior art date
Application number
CL200302042A
Other languages
English (en)
Spanish (es)
Inventor
Olivier Bur Daniel Fi Bezencon
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29286070&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2003002042(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of CL2003002042A1 publication Critical patent/CL2003002042A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CL200302042A 2002-04-29 2003-10-10 Compuestos derivados de 3,9-diazabiciclo[3.3.1]noneno; composicion farmaceutica; y uso del compuesto como inhibidor de renina (ras), para tratar hipertension, insuficiencia cardiaca congestiva, hipertension pulmonar, insuficiencia renal, ateroscleros CL2003002042A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP0204705 2002-04-29
PCT/EP2003/003721 WO2003093267A1 (en) 2002-04-29 2003-04-08 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases

Publications (1)

Publication Number Publication Date
CL2003002042A1 true CL2003002042A1 (es) 2005-02-04

Family

ID=29286070

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200302042A CL2003002042A1 (es) 2002-04-29 2003-10-10 Compuestos derivados de 3,9-diazabiciclo[3.3.1]noneno; composicion farmaceutica; y uso del compuesto como inhibidor de renina (ras), para tratar hipertension, insuficiencia cardiaca congestiva, hipertension pulmonar, insuficiencia renal, ateroscleros

Country Status (26)

Country Link
US (2) US7427613B2 (enExample)
EP (1) EP1501830B1 (enExample)
JP (1) JP4041123B2 (enExample)
KR (1) KR100783863B1 (enExample)
CN (1) CN1649870A (enExample)
AT (1) ATE527261T1 (enExample)
AU (1) AU2003233963B2 (enExample)
BR (1) BR0309498A (enExample)
CA (1) CA2483241C (enExample)
CL (1) CL2003002042A1 (enExample)
CO (1) CO5631443A2 (enExample)
EC (1) ECSP045378A (enExample)
ES (1) ES2372931T3 (enExample)
HR (1) HRP20041132A2 (enExample)
IL (1) IL164767A0 (enExample)
IS (1) IS7545A (enExample)
MA (1) MA27305A1 (enExample)
MX (1) MXPA04010608A (enExample)
NO (1) NO20045042L (enExample)
NZ (1) NZ536750A (enExample)
PL (1) PL372141A1 (enExample)
RU (1) RU2343153C2 (enExample)
TW (1) TW200514786A (enExample)
UA (1) UA80821C2 (enExample)
WO (1) WO2003093267A1 (enExample)
ZA (1) ZA200408283B (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060217371A1 (en) * 2003-04-28 2006-09-28 Olivier Bezencon Diazabicyclononene and tetrahydropyriddine derivatives as renin inhibitors
JP2006524657A (ja) * 2003-04-30 2006-11-02 アクテリオン　ファマシューティカルズ　リミテッド 新規トロパン誘導体
AU2004234038A1 (en) * 2003-04-30 2004-11-11 Actelion Pharmaceuticals Ltd. Azabicyclononene derivatives
AU2004233575A1 (en) * 2003-04-30 2004-11-11 Actelion Pharmaceuticals Ltd 9-azabicyclo'3.3.1!non-6-ee derivatives with a heteroatom at the 3-position as renin inhibitors
RU2005137571A (ru) * 2003-05-02 2006-05-10 Актелион Фармасьютикалз Лтд. (Ch) Новые производные диазабициклононена
WO2004105762A1 (en) * 2003-05-30 2004-12-09 Actelion Pharmaceuticals Ltd Medical use of diazabicyclononene derivatives as inhibitors of parasite aspartic proteases
CN1863773A (zh) * 2003-10-09 2006-11-15 埃科特莱茵药品有限公司 四氢吡啶衍生物
US20070142363A1 (en) * 2003-10-13 2007-06-21 Actelion Pharmaceuticals Ltd Novel diazabicyclonene derivatives and use thereof
US20070135405A1 (en) * 2003-10-23 2007-06-14 Olivier Bezencon Novel diazabicyclononene and tetrahydropyridine derivatives with a new polar side-chain
US20070135406A1 (en) * 2003-12-05 2007-06-14 Olivier Bezencon Diazabicyclononene and tetrahydropyridine derivatives with a new side-chain
WO2005054243A1 (en) * 2003-12-05 2005-06-16 Actelion Pharmaceuticals Ltd Diazabicyclononene derivatives and their use as renin inhibitors
JP2008510755A (ja) * 2004-08-25 2008-04-10 アクテリオン ファーマシューティカルズ リミテッド ビシクロノネン誘導体
WO2006021399A2 (en) * 2004-08-25 2006-03-02 Actelion Pharmaceuticals Ltd Azabicyclononene derivatives as renin inhibitors
WO2006021403A1 (en) * 2004-08-25 2006-03-02 Actelion Pharmaceuticals Ltd Bicyclononene derivatives
WO2006021401A2 (en) * 2004-08-25 2006-03-02 Actelion Pharmaceuticals Ltd Bicylononene derivatives
AR052263A1 (es) * 2004-12-08 2007-03-07 Actelion Pharmaceuticals Ltd Derivado de diazabiciclononeno
WO2006063610A1 (en) * 2004-12-17 2006-06-22 Actelion Pharmaceuticals Ltd Heteroaryl substituted diazabicyclononene derivatives
GB0428526D0 (en) 2004-12-30 2005-02-09 Novartis Ag Organic compounds
CA2595986A1 (en) * 2005-01-28 2006-08-03 Actelion Pharmaceuticals Ltd 7-{4-[2-(2,6-dichlor0-4-methylphenoxy)-ethoxy]phenyl}-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylic acid cyclopropyl-(2,3-dimethylbenzyl)amides as inhibitors of renin for the treatment of hypertension
KR100963455B1 (ko) * 2005-05-27 2010-06-18 액테리온 파마슈티칼 리미티드 신규한 피페리딘 카르복실산 아미드 유도체
GB0514203D0 (en) 2005-07-11 2005-08-17 Novartis Ag Organic compounds
ES2430139T3 (es) 2005-12-30 2013-11-19 Novartis Ag Compuestos de piperidina 3,5-sustituido como inhibidores de renina
JP2009526767A (ja) 2006-02-02 2009-07-23 アクテリオン ファーマシューティカルズ リミテッド 新規二級アミン
TW200800897A (en) * 2006-03-08 2008-01-01 Actelion Pharmaceuticals Ltd New amines
EP2162436A4 (en) 2007-05-24 2010-08-04 Merck Frosst Canada Ltd NEW CASE OF RENININHIBITORS
EP2181105B1 (en) 2007-06-25 2015-04-29 Novartis AG N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors
CA2696689A1 (en) 2007-08-20 2009-02-26 Merck Frosst Canada Ltd. Renin inhibitors
CN102015682B (zh) 2008-05-05 2014-07-16 埃科特莱茵药品有限公司 作为肾素抑制剂的3,4-取代的哌啶衍生物
CN109721613B (zh) * 2017-10-27 2021-07-30 四川科伦博泰生物医药股份有限公司 含季铵离子的大环酰胺化合物及其药物组合物和用途

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US3509161A (en) * 1967-07-10 1970-04-28 Boehringer & Soehne Gmbh 3-phenyl-granatene-(2)-derivatives
GB9020927D0 (en) 1990-09-26 1990-11-07 Beecham Group Plc Pharmaceuticals
US5268361A (en) * 1991-06-07 1993-12-07 Sri International Hydroxyazido derivatives and related compounds as renin inhibitors
US5374719A (en) * 1993-06-04 1994-12-20 Eli Lilly And Company Process for converting loracarbef dihydrate to loracarbef monohydrate
KR100384979B1 (ko) 1995-09-07 2003-10-17 에프. 호프만-라 로슈 아게 심부전증및신부전증치료용의신규한4-(옥시알콕시페닐)-3-옥시-피페리딘
WO1998039328A1 (en) 1997-03-03 1998-09-11 F.Hoffmann-La Roche Ag Substituted 2,4-diaminopyrimidines
US20060223795A1 (en) * 2003-05-02 2006-10-05 Oliver Bezencon Novel diazabicyclononene derivatives
WO2005054243A1 (en) * 2003-12-05 2005-06-16 Actelion Pharmaceuticals Ltd Diazabicyclononene derivatives and their use as renin inhibitors

Also Published As

Publication number Publication date
CO5631443A2 (es) 2006-04-28
PL372141A1 (en) 2005-07-11
CA2483241A1 (en) 2003-11-13
BR0309498A (pt) 2005-02-15
CN1649870A (zh) 2005-08-03
AU2003233963B2 (en) 2008-09-11
JP4041123B2 (ja) 2008-01-30
MA27305A1 (fr) 2005-05-02
RU2343153C2 (ru) 2009-01-10
WO2003093267A1 (en) 2003-11-13
EP1501830B1 (en) 2011-10-05
US7427613B2 (en) 2008-09-23
ECSP045378A (es) 2004-11-26
NO20045042L (no) 2004-11-19
CA2483241C (en) 2011-05-31
IS7545A (is) 2004-11-22
AU2003233963A1 (en) 2003-11-17
RU2004134320A (ru) 2005-08-27
KR100783863B1 (ko) 2007-12-10
UA80821C2 (en) 2007-11-12
TW200514786A (en) 2005-05-01
ES2372931T3 (es) 2012-01-27
KR20040101546A (ko) 2004-12-02
NZ536750A (en) 2007-02-23
MXPA04010608A (es) 2004-12-13
HRP20041132A2 (en) 2006-07-31
ZA200408283B (en) 2006-05-31
ATE527261T1 (de) 2011-10-15
US20050176700A1 (en) 2005-08-11
US20080312242A1 (en) 2008-12-18
JP2005527602A (ja) 2005-09-15
EP1501830A1 (en) 2005-02-02
IL164767A0 (en) 2005-12-18

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