WO2007034445A3 - Novel piperazine derivatives as renin inhibitors for cardiovascular events and renal insufficiency - Google Patents

Novel piperazine derivatives as renin inhibitors for cardiovascular events and renal insufficiency Download PDF

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Publication number
WO2007034445A3
WO2007034445A3 PCT/IB2006/053445 IB2006053445W WO2007034445A3 WO 2007034445 A3 WO2007034445 A3 WO 2007034445A3 IB 2006053445 W IB2006053445 W IB 2006053445W WO 2007034445 A3 WO2007034445 A3 WO 2007034445A3
Authority
WO
WIPO (PCT)
Prior art keywords
piperazine derivatives
renal insufficiency
cardiovascular events
renin inhibitors
novel piperazine
Prior art date
Application number
PCT/IB2006/053445
Other languages
French (fr)
Other versions
WO2007034445A2 (en
Inventor
Olivier Bezencon
Christoph Boss
Daniel Bur
Olivier Corminboeuf
Corinna Grisostomi
Lubos Remen
Sylvia Richard-Bildstein
Thomas Weller
Original Assignee
Actelion Pharmaceuticals Ltd
Olivier Bezencon
Christoph Boss
Daniel Bur
Olivier Corminboeuf
Corinna Grisostomi
Lubos Remen
Sylvia Richard-Bildstein
Thomas Weller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd, Olivier Bezencon, Christoph Boss, Daniel Bur, Olivier Corminboeuf, Corinna Grisostomi, Lubos Remen, Sylvia Richard-Bildstein, Thomas Weller filed Critical Actelion Pharmaceuticals Ltd
Publication of WO2007034445A2 publication Critical patent/WO2007034445A2/en
Publication of WO2007034445A3 publication Critical patent/WO2007034445A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to novel piperazine derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin. In particular, the present invention relates to novel compounds of the formula (I),
PCT/IB2006/053445 2005-09-26 2006-09-22 Novel piperazine derivatives as renin inhibitors for cardiovascular events and renal insufficiency WO2007034445A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2005010368 2005-09-26
EPPCT/EP2005/010368 2005-09-26

Publications (2)

Publication Number Publication Date
WO2007034445A2 WO2007034445A2 (en) 2007-03-29
WO2007034445A3 true WO2007034445A3 (en) 2008-11-20

Family

ID=37889238

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/053445 WO2007034445A2 (en) 2005-09-26 2006-09-22 Novel piperazine derivatives as renin inhibitors for cardiovascular events and renal insufficiency

Country Status (1)

Country Link
WO (1) WO2007034445A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8129538B1 (en) 2007-03-28 2012-03-06 Takeda Pharmaceutical Company Limited Renin inhibitors
US8343968B2 (en) 2007-05-24 2013-01-01 Merck Canada Inc. Case of renin inhibitors
AU2008288648A1 (en) 2007-08-20 2009-02-26 Merck Frosst Canada Ltd. Renin inhibitors
AU2009243875B2 (en) 2008-05-05 2011-12-01 Idorsia Pharmaceuticals Ltd 3, 4 - substituted piperidine derivatives as renin inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005037803A1 (en) * 2003-10-09 2005-04-28 Speedel Experimenta Ag Organic compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005037803A1 (en) * 2003-10-09 2005-04-28 Speedel Experimenta Ag Organic compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RAHUEL J ET AL: "Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 7, no. 7, 1 July 2000 (2000-07-01), pages 493 - 504, XP002254255, ISSN: 1074-5521 *

Also Published As

Publication number Publication date
WO2007034445A2 (en) 2007-03-29

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