CH651932A5 - Verfahren zur bestimmung von encainid und metaboliten davon in biologischen fluessigkeiten. - Google Patents
Verfahren zur bestimmung von encainid und metaboliten davon in biologischen fluessigkeiten. Download PDFInfo
- Publication number
- CH651932A5 CH651932A5 CH90/85A CH9085A CH651932A5 CH 651932 A5 CH651932 A5 CH 651932A5 CH 90/85 A CH90/85 A CH 90/85A CH 9085 A CH9085 A CH 9085A CH 651932 A5 CH651932 A5 CH 651932A5
- Authority
- CH
- Switzerland
- Prior art keywords
- encainide
- metabolites
- compound
- determining
- biological liquids
- Prior art date
Links
- PJWPNDMDCLXCOM-UHFFFAOYSA-N encainide Chemical compound C1=CC(OC)=CC=C1C(=O)NC1=CC=CC=C1CCC1N(C)CCCC1 PJWPNDMDCLXCOM-UHFFFAOYSA-N 0.000 title description 16
- 229960001142 encainide Drugs 0.000 title description 13
- 238000000034 method Methods 0.000 title description 10
- 239000002207 metabolite Substances 0.000 title description 6
- 239000007788 liquid Substances 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 description 18
- 238000004128 high performance liquid chromatography Methods 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 210000002381 plasma Anatomy 0.000 description 6
- 229940126062 Compound A Drugs 0.000 description 5
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 5
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 5
- KHWTYGFHPHRQMP-UHFFFAOYSA-N (4-propan-2-ylcyclohexyl)methanol Chemical compound CC(C)C1CCC(CO)CC1 KHWTYGFHPHRQMP-UHFFFAOYSA-N 0.000 description 4
- AZUVBPVDRHGGEP-UHFFFAOYSA-N 6a,9a-dimethyl-4,5,7,8,9,9a-hexahydro-6aH-dipyrrolo(2,3-b;3',2',1'-hi)indole Natural products CC(=C)C1CCC(C)=CCCC(C)=CCCC(C)=CC1O AZUVBPVDRHGGEP-UHFFFAOYSA-N 0.000 description 4
- WSTYNZDAOAEEKG-UHFFFAOYSA-N Mayol Natural products CC1=C(O)C(=O)C=C2C(CCC3(C4CC(C(CC4(CCC33C)C)=O)C)C)(C)C3=CC=C21 WSTYNZDAOAEEKG-UHFFFAOYSA-N 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 230000003288 anthiarrhythmic effect Effects 0.000 description 2
- 239000003416 antiarrhythmic agent Substances 0.000 description 2
- 239000013060 biological fluid Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 229960004121 encainide hydrochloride Drugs 0.000 description 2
- OJIIZIWOLTYOBS-UHFFFAOYSA-N encainide hydrochloride Chemical compound Cl.C1=CC(OC)=CC=C1C(=O)NC1=CC=CC=C1CCC1N(C)CCCC1 OJIIZIWOLTYOBS-UHFFFAOYSA-N 0.000 description 2
- 229940098779 methanesulfonic acid Drugs 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- VFWCMGCRMGJXDK-UHFFFAOYSA-N 1-chlorobutane Chemical compound CCCCCl VFWCMGCRMGJXDK-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- QLMVRMLCNYDKJN-UHFFFAOYSA-N 4-methoxy-n-[2-(2-piperidin-2-ylethyl)phenyl]benzamide Chemical compound C1=CC(OC)=CC=C1C(=O)NC1=CC=CC=C1CCC1NCCCC1 QLMVRMLCNYDKJN-UHFFFAOYSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000906446 Theraps Species 0.000 description 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 229930182851 human metabolite Natural products 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/188,184 US4332803A (en) | 1980-09-18 | 1980-09-18 | Benzanilide derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH651932A5 true CH651932A5 (de) | 1985-10-15 |
Family
ID=22692080
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH90/85A CH651932A5 (de) | 1980-09-18 | 1981-09-17 | Verfahren zur bestimmung von encainid und metaboliten davon in biologischen fluessigkeiten. |
| CH6017/81A CH650497A5 (de) | 1980-09-18 | 1981-09-17 | 4-hydroxy-3-methoxy-n-(2-(2-(1-methyl-2-piperidinyl)-aethyl)-phenyl)-benzamid und saeureadditionssalze davon. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH6017/81A CH650497A5 (de) | 1980-09-18 | 1981-09-17 | 4-hydroxy-3-methoxy-n-(2-(2-(1-methyl-2-piperidinyl)-aethyl)-phenyl)-benzamid und saeureadditionssalze davon. |
Country Status (25)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4618680A (en) * | 1980-09-18 | 1986-10-21 | Mead Johnson & Company | Benzanilide derivative |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA961038A (en) * | 1971-03-03 | 1975-01-14 | Joseph L. Minielli | Substituted piperidines |
| US3931195A (en) * | 1971-03-03 | 1976-01-06 | Mead Johnson & Company | Substituted piperidines |
-
1980
- 1980-09-18 US US06/188,184 patent/US4332803A/en not_active Expired - Lifetime
-
1981
- 1981-09-08 CY CY137081A patent/CY1370A/en unknown
- 1981-09-08 GB GB8127079A patent/GB2084570B/en not_active Expired
- 1981-09-11 YU YU2192/81A patent/YU42425B/xx unknown
- 1981-09-11 AU AU75181/81A patent/AU526825B2/en not_active Ceased
- 1981-09-14 ZA ZA816348A patent/ZA816348B/xx unknown
- 1981-09-15 FI FI812873A patent/FI66597C/fi not_active IP Right Cessation
- 1981-09-15 NL NL8104261A patent/NL8104261A/nl not_active Application Discontinuation
- 1981-09-15 FR FR8117391A patent/FR2494267B1/fr not_active Expired
- 1981-09-16 DK DK412881A patent/DK152121C/da not_active IP Right Cessation
- 1981-09-17 IT IT8149311A patent/IT1209900B/it active
- 1981-09-17 GR GR66079A patent/GR75788B/el unknown
- 1981-09-17 IE IE2160/81A patent/IE51584B1/en not_active IP Right Cessation
- 1981-09-17 DE DE3137084A patent/DE3137084C2/de not_active Expired
- 1981-09-17 DE DE3153300A patent/DE3153300C2/de not_active Expired
- 1981-09-17 CH CH90/85A patent/CH651932A5/de not_active IP Right Cessation
- 1981-09-17 CH CH6017/81A patent/CH650497A5/de not_active IP Right Cessation
- 1981-09-18 AT AT0403781A patent/AT378181B/de active
- 1981-09-18 CA CA000386216A patent/CA1183537A/en not_active Expired
- 1981-09-18 BE BE0/206007A patent/BE890418A/fr not_active IP Right Cessation
- 1981-09-18 JP JP56146406A patent/JPS5782368A/ja active Granted
- 1981-09-18 LU LU83644A patent/LU83644A1/fr unknown
- 1981-09-18 AR AR286799A patent/AR227065A1/es active
- 1981-09-18 SE SE8105538A patent/SE445215B/sv not_active IP Right Cessation
-
1984
- 1984-02-02 GB GB08402839A patent/GB2144050B/en not_active Expired
- 1984-02-02 CY CY137784A patent/CY1377A/en unknown
-
1987
- 1987-03-27 SG SG301/87A patent/SG30187G/en unknown
- 1987-03-31 KE KE3716A patent/KE3716A/xx unknown
- 1987-03-31 KE KE3717A patent/KE3717A/xx unknown
-
1988
- 1988-01-21 HK HK53/88A patent/HK5388A/xx unknown
- 1988-01-21 HK HK44/88A patent/HK4488A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |