CH642978A5 - Verfahren zur herstellung von 12-beta-hydroxycardenolidverbindungen. - Google Patents
Verfahren zur herstellung von 12-beta-hydroxycardenolidverbindungen. Download PDFInfo
- Publication number
- CH642978A5 CH642978A5 CH477179A CH477179A CH642978A5 CH 642978 A5 CH642978 A5 CH 642978A5 CH 477179 A CH477179 A CH 477179A CH 477179 A CH477179 A CH 477179A CH 642978 A5 CH642978 A5 CH 642978A5
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- CH
- Switzerland
- Prior art keywords
- formula
- compounds
- culture
- digitoxin
- general formula
- Prior art date
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- SGCWCAMXENXYHU-MHMIYUGKSA-N 3-[(8R,9S,10S,13R,14R,17R)-13-(hydroxymethyl)-10-methyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one Chemical class OC[C@]12CC[C@H]3[C@@H](CCC4CCCC[C@]34C)[C@H]1CC[C@@H]2C=1COC(=O)C=1 SGCWCAMXENXYHU-MHMIYUGKSA-N 0.000 title 1
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- 239000011521 glass Substances 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
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- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
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- 239000011777 magnesium Substances 0.000 description 1
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- HOVAGTYPODGVJG-ZFYZTMLRSA-N methyl alpha-D-glucopyranoside Chemical compound CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HOVAGTYPODGVJG-ZFYZTMLRSA-N 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 229940055695 pancreatin Drugs 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 238000012746 preparative thin layer chromatography Methods 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- NGFMICBWJRZIBI-UJPOAAIJSA-N salicin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UJPOAAIJSA-N 0.000 description 1
- 229940120668 salicin Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/06—Hydroxylating
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
- C07J19/005—Glycosides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU78GO1405A HU175474B (hu) | 1978-05-23 | 1978-05-23 | Novyjj mikrobiologicheskijj sposob poluchenija proizvodnykh kardenolida soderzhahhikh gruppu 12-beta-gidroksila |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH642978A5 true CH642978A5 (de) | 1984-05-15 |
Family
ID=10996859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH477179A CH642978A5 (de) | 1978-05-23 | 1979-05-22 | Verfahren zur herstellung von 12-beta-hydroxycardenolidverbindungen. |
Country Status (6)
| Country | Link |
|---|---|
| CH (1) | CH642978A5 (enrdf_load_stackoverflow) |
| DD (1) | DD143927A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2921052A1 (enrdf_load_stackoverflow) |
| GB (1) | GB2023144B (enrdf_load_stackoverflow) |
| HU (1) | HU175474B (enrdf_load_stackoverflow) |
| NL (1) | NL7904103A (enrdf_load_stackoverflow) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU176250B (en) * | 1978-10-30 | 1981-01-28 | Gyogyszerkutato Intezet | Process for producing mikrobiologically 12-beta-hydroxycardenolide derivatives |
| WO1996015253A1 (de) * | 1994-11-14 | 1996-05-23 | Schering Aktiengesellschaft | Verfahren zur herstellung von 1-hydroxymethyl-1.4-androstadien-3.17-dion |
-
1978
- 1978-05-23 HU HU78GO1405A patent/HU175474B/hu not_active IP Right Cessation
-
1979
- 1979-05-21 DD DD21303179A patent/DD143927A5/de not_active IP Right Cessation
- 1979-05-22 CH CH477179A patent/CH642978A5/de not_active IP Right Cessation
- 1979-05-23 GB GB7918023A patent/GB2023144B/en not_active Expired
- 1979-05-23 NL NL7904103A patent/NL7904103A/xx not_active Application Discontinuation
- 1979-05-23 DE DE19792921052 patent/DE2921052A1/de active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| GB2023144B (en) | 1982-11-03 |
| DD143927A5 (de) | 1980-09-17 |
| GB2023144A (en) | 1979-12-28 |
| DE2921052A1 (de) | 1980-01-17 |
| NL7904103A (nl) | 1979-11-27 |
| DE2921052C2 (enrdf_load_stackoverflow) | 1987-10-29 |
| HU175474B (hu) | 1980-08-28 |
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