GB2023144A - Microbial preparation of 12 beta - hydroxy-cardenolide derivatives - Google Patents
Microbial preparation of 12 beta - hydroxy-cardenolide derivativesInfo
- Publication number
- GB2023144A GB2023144A GB7918023A GB7918023A GB2023144A GB 2023144 A GB2023144 A GB 2023144A GB 7918023 A GB7918023 A GB 7918023A GB 7918023 A GB7918023 A GB 7918023A GB 2023144 A GB2023144 A GB 2023144A
- Authority
- GB
- United Kingdom
- Prior art keywords
- beta
- hydroxy
- microbial preparation
- mng
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/06—Hydroxylating
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
- C07J19/005—Glycosides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
12-Deoxy-cardiac glycosides or their aglycones (e.g. digitoxin) are converted to 12 beta -hydroxy derivatives (e.g. digoxin and 7 beta -hydroxydigoxin) by contacting under aerobic conditions with a culture of Streptomyces praecox MNG 127. (MNG = Hungarian National Collection of Microorganisms, Budapest).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU78GO1405A HU175474B (en) | 1978-05-23 | 1978-05-23 | New microbiological process for producingcardenolide compounds containing 12-beta-hydroxyl-group |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2023144A true GB2023144A (en) | 1979-12-28 |
GB2023144B GB2023144B (en) | 1982-11-03 |
Family
ID=10996859
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB7918023A Expired GB2023144B (en) | 1978-05-23 | 1979-05-23 | Microbial preparation of 12s-hydroxy-cardenolide derivatives |
Country Status (6)
Country | Link |
---|---|
CH (1) | CH642978A5 (en) |
DD (1) | DD143927A5 (en) |
DE (1) | DE2921052A1 (en) |
GB (1) | GB2023144B (en) |
HU (1) | HU175474B (en) |
NL (1) | NL7904103A (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU176250B (en) * | 1978-10-30 | 1981-01-28 | Gyogyszerkutato Intezet | Process for producing mikrobiologically 12-beta-hydroxycardenolide derivatives |
WO1996015253A1 (en) * | 1994-11-14 | 1996-05-23 | Schering Aktiengesellschaft | Process for producing 1-hydroxymethyl-1.4-androstadiene-3.17-dione |
-
1978
- 1978-05-23 HU HU78GO1405A patent/HU175474B/en not_active IP Right Cessation
-
1979
- 1979-05-21 DD DD21303179A patent/DD143927A5/en not_active IP Right Cessation
- 1979-05-22 CH CH477179A patent/CH642978A5/en not_active IP Right Cessation
- 1979-05-23 NL NL7904103A patent/NL7904103A/en not_active Application Discontinuation
- 1979-05-23 GB GB7918023A patent/GB2023144B/en not_active Expired
- 1979-05-23 DE DE19792921052 patent/DE2921052A1/en active Granted
Also Published As
Publication number | Publication date |
---|---|
CH642978A5 (en) | 1984-05-15 |
DE2921052A1 (en) | 1980-01-17 |
GB2023144B (en) | 1982-11-03 |
NL7904103A (en) | 1979-11-27 |
DE2921052C2 (en) | 1987-10-29 |
DD143927A5 (en) | 1980-09-17 |
HU175474B (en) | 1980-08-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |