GB2023144A - Microbial preparation of 12 beta - hydroxy-cardenolide derivatives - Google Patents

Microbial preparation of 12 beta - hydroxy-cardenolide derivatives

Info

Publication number
GB2023144A
GB2023144A GB7918023A GB7918023A GB2023144A GB 2023144 A GB2023144 A GB 2023144A GB 7918023 A GB7918023 A GB 7918023A GB 7918023 A GB7918023 A GB 7918023A GB 2023144 A GB2023144 A GB 2023144A
Authority
GB
United Kingdom
Prior art keywords
beta
hydroxy
microbial preparation
mng
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7918023A
Other versions
GB2023144B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of GB2023144A publication Critical patent/GB2023144A/en
Application granted granted Critical
Publication of GB2023144B publication Critical patent/GB2023144B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
    • C07J19/005—Glycosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

12-Deoxy-cardiac glycosides or their aglycones (e.g. digitoxin) are converted to 12 beta -hydroxy derivatives (e.g. digoxin and 7 beta -hydroxydigoxin) by contacting under aerobic conditions with a culture of Streptomyces praecox MNG 127. (MNG = Hungarian National Collection of Microorganisms, Budapest).
GB7918023A 1978-05-23 1979-05-23 Microbial preparation of 12s-hydroxy-cardenolide derivatives Expired GB2023144B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU78GO1405A HU175474B (en) 1978-05-23 1978-05-23 New microbiological process for producingcardenolide compounds containing 12-beta-hydroxyl-group

Publications (2)

Publication Number Publication Date
GB2023144A true GB2023144A (en) 1979-12-28
GB2023144B GB2023144B (en) 1982-11-03

Family

ID=10996859

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7918023A Expired GB2023144B (en) 1978-05-23 1979-05-23 Microbial preparation of 12s-hydroxy-cardenolide derivatives

Country Status (6)

Country Link
CH (1) CH642978A5 (en)
DD (1) DD143927A5 (en)
DE (1) DE2921052A1 (en)
GB (1) GB2023144B (en)
HU (1) HU175474B (en)
NL (1) NL7904103A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU176250B (en) * 1978-10-30 1981-01-28 Gyogyszerkutato Intezet Process for producing mikrobiologically 12-beta-hydroxycardenolide derivatives
WO1996015253A1 (en) * 1994-11-14 1996-05-23 Schering Aktiengesellschaft Process for producing 1-hydroxymethyl-1.4-androstadiene-3.17-dione

Also Published As

Publication number Publication date
CH642978A5 (en) 1984-05-15
DD143927A5 (en) 1980-09-17
HU175474B (en) 1980-08-28
DE2921052C2 (en) 1987-10-29
GB2023144B (en) 1982-11-03
NL7904103A (en) 1979-11-27
DE2921052A1 (en) 1980-01-17

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee