CH642067A5 - Sels phosphates de la 1- et de la d,1-glaucine, leur utilisation dans des compositions pharmaceutiques et procede pour leur preparation. - Google Patents
Sels phosphates de la 1- et de la d,1-glaucine, leur utilisation dans des compositions pharmaceutiques et procede pour leur preparation. Download PDFInfo
- Publication number
- CH642067A5 CH642067A5 CH759679A CH759679A CH642067A5 CH 642067 A5 CH642067 A5 CH 642067A5 CH 759679 A CH759679 A CH 759679A CH 759679 A CH759679 A CH 759679A CH 642067 A5 CH642067 A5 CH 642067A5
- Authority
- CH
- Switzerland
- Prior art keywords
- glaucine
- phosphate
- phosphoric acid
- compound
- mixture
- Prior art date
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- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical class OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 title claims description 76
- 238000000034 method Methods 0.000 title claims description 23
- 238000002360 preparation method Methods 0.000 title claims description 10
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- 229940113086 glaucine Drugs 0.000 claims description 131
- 229910019142 PO4 Inorganic materials 0.000 claims description 93
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 82
- 239000010452 phosphate Substances 0.000 claims description 82
- DABPOQZSGVNAAS-UHFFFAOYSA-N Glaucocalactone Natural products O=CC12C3C(C4)OC(=O)C2C(C)(C)CCC1OC(=O)C13CC4C(=C)C1OC(=O)C DABPOQZSGVNAAS-UHFFFAOYSA-N 0.000 claims description 63
- RUZIUYOSRDWYQF-HNNXBMFYSA-N (S)-glaucine Chemical compound CN1CCC2=CC(OC)=C(OC)C3=C2[C@@H]1CC1=C3C=C(OC)C(OC)=C1 RUZIUYOSRDWYQF-HNNXBMFYSA-N 0.000 claims description 59
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 58
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- 150000001875 compounds Chemical class 0.000 claims description 24
- 150000003839 salts Chemical class 0.000 claims description 20
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- 239000008213 purified water Substances 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 150000003890 succinate salts Chemical class 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93522178A | 1978-08-21 | 1978-08-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH642067A5 true CH642067A5 (fr) | 1984-03-30 |
Family
ID=25466735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH759679A CH642067A5 (fr) | 1978-08-21 | 1979-08-20 | Sels phosphates de la 1- et de la d,1-glaucine, leur utilisation dans des compositions pharmaceutiques et procede pour leur preparation. |
Country Status (22)
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2625116C2 (de) * | 1976-06-04 | 1984-01-26 | Gödecke AG, 1000 Berlin | Verfahren zur Herstellung von 4-Hydroxy-aporphin-Derivaten |
| DE2717062C2 (de) * | 1977-04-18 | 1982-11-25 | Karl O. Helm Ag, 2000 Hamburg | Arzneimittel mit antitussiver Wirkung |
-
1979
- 1979-07-27 FI FI792358A patent/FI68813C/fi not_active IP Right Cessation
- 1979-07-30 GR GR59728A patent/GR69880B/el unknown
- 1979-07-31 IT IT24783/79A patent/IT1123512B/it active
- 1979-07-31 AU AU49397/79A patent/AU532383B2/en not_active Ceased
- 1979-07-31 NZ NZ191170A patent/NZ191170A/en unknown
- 1979-07-31 IL IL57935A patent/IL57935A/xx unknown
- 1979-08-03 GB GB7927227A patent/GB2028322B/en not_active Expired
- 1979-08-08 ZA ZA00794133A patent/ZA794133B/xx unknown
- 1979-08-14 DE DE19792932834 patent/DE2932834A1/de active Granted
- 1979-08-15 NL NLAANVRAGE7906215,A patent/NL182284C/xx not_active IP Right Cessation
- 1979-08-17 AT AT0558579A patent/AT374799B/de not_active IP Right Cessation
- 1979-08-20 PT PT70088A patent/PT70088B/pt unknown
- 1979-08-20 DK DK347179A patent/DK347179A/da not_active Application Discontinuation
- 1979-08-20 JP JP10583979A patent/JPS5528999A/ja active Pending
- 1979-08-20 CH CH759679A patent/CH642067A5/fr not_active IP Right Cessation
- 1979-08-20 SE SE7906941A patent/SE7906941L/xx not_active Application Discontinuation
- 1979-08-20 NO NO792705A patent/NO150759C/no unknown
- 1979-08-20 IE IE1598/79A patent/IE48807B1/en unknown
- 1979-08-20 CA CA000334099A patent/CA1117528A/en not_active Expired
- 1979-08-20 ES ES483499A patent/ES483499A1/es not_active Expired
- 1979-08-21 FR FR7921098A patent/FR2434153A1/fr active Granted
- 1979-08-21 BE BE0/196822A patent/BE878356A/fr not_active IP Right Cessation
-
1985
- 1985-04-18 SE SE8501907A patent/SE8501907D0/xx not_active Application Discontinuation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |