CH634104A5 - Process for the preparation of the novel antibiotic MSD 890A10 - Google Patents

Process for the preparation of the novel antibiotic MSD 890A10 Download PDF

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Publication number
CH634104A5
CH634104A5 CH1401477A CH1401477A CH634104A5 CH 634104 A5 CH634104 A5 CH 634104A5 CH 1401477 A CH1401477 A CH 1401477A CH 1401477 A CH1401477 A CH 1401477A CH 634104 A5 CH634104 A5 CH 634104A5
Authority
CH
Switzerland
Prior art keywords
fractions
antibiotic
medium
890aio
column
Prior art date
Application number
CH1401477A
Other languages
German (de)
English (en)
Inventor
Patrick Joseph Cassidy
Sheldon Bernard Zimmerman
Josefino Ballesteros Tunac
Sebastian Hernandez
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CH634104A5 publication Critical patent/CH634104A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CH1401477A 1976-11-17 1977-11-16 Process for the preparation of the novel antibiotic MSD 890A10 CH634104A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74295876A 1976-11-17 1976-11-17

Publications (1)

Publication Number Publication Date
CH634104A5 true CH634104A5 (en) 1983-01-14

Family

ID=24986929

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1401477A CH634104A5 (en) 1976-11-17 1977-11-16 Process for the preparation of the novel antibiotic MSD 890A10

Country Status (10)

Country Link
JP (1) JPS5363397A (xx)
CH (1) CH634104A5 (xx)
DE (1) DE2751303A1 (xx)
DK (1) DK487977A (xx)
ES (1) ES463973A1 (xx)
FR (1) FR2371448A1 (xx)
GB (1) GB1595233A (xx)
NL (1) NL7712092A (xx)
PT (1) PT67268B (xx)
SE (1) SE433621B (xx)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ190994A (en) 1978-07-24 1981-10-19 Merck & Co Inc Z-2-acylamino-3-monosubstituted propenoates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1483142A (en) * 1975-03-15 1977-08-17 Beecham Group Ltd Streptomycetal antibiotic
CH633554A5 (en) * 1975-11-21 1982-12-15 Merck & Co Inc Process for the preparation of novel thienamycin derivatives.

Also Published As

Publication number Publication date
FR2371448B1 (xx) 1980-03-14
SE7712430L (sv) 1978-05-18
ES463973A1 (es) 1978-11-16
DK487977A (da) 1978-05-18
PT67268A (en) 1977-12-01
FR2371448A1 (fr) 1978-06-16
PT67268B (en) 1979-10-08
DE2751303A1 (de) 1978-05-18
SE433621B (sv) 1984-06-04
NL7712092A (nl) 1978-05-19
JPS6310998B2 (xx) 1988-03-10
GB1595233A (en) 1981-08-12
JPS5363397A (en) 1978-06-06

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