ES463973A1 - Un procedimiento para la preparacion del antibiotico 890a10. - Google Patents

Un procedimiento para la preparacion del antibiotico 890a10.

Info

Publication number
ES463973A1
ES463973A1 ES463973A ES463973A ES463973A1 ES 463973 A1 ES463973 A1 ES 463973A1 ES 463973 A ES463973 A ES 463973A ES 463973 A ES463973 A ES 463973A ES 463973 A1 ES463973 A1 ES 463973A1
Authority
ES
Spain
Prior art keywords
antibiotic
gram
novel
lactamases
feedstuffs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES463973A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES463973A1 publication Critical patent/ES463973A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Un procedimiento para la preparación del antibiótico 890A10 de fórmula ***(Ver fórmula I) y sus sales farmacéuticamente aceptables, cuyo procedimiento consiste en cultivar una cepa productora de 890A10 de Streptomyces Flavogriseus en un medio nutritivo acuoso que contiene fuentes asimilables de carbono, nitrógeno y sales inorgánicas, en condiciones aerobias sumergidas y recuperar dicho antibiótico.
ES463973A 1976-11-17 1977-11-08 Un procedimiento para la preparacion del antibiotico 890a10. Expired ES463973A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74295876A 1976-11-17 1976-11-17

Publications (1)

Publication Number Publication Date
ES463973A1 true ES463973A1 (es) 1978-11-16

Family

ID=24986929

Family Applications (1)

Application Number Title Priority Date Filing Date
ES463973A Expired ES463973A1 (es) 1976-11-17 1977-11-08 Un procedimiento para la preparacion del antibiotico 890a10.

Country Status (10)

Country Link
JP (1) JPS5363397A (es)
CH (1) CH634104A5 (es)
DE (1) DE2751303A1 (es)
DK (1) DK487977A (es)
ES (1) ES463973A1 (es)
FR (1) FR2371448A1 (es)
GB (1) GB1595233A (es)
NL (1) NL7712092A (es)
PT (1) PT67268B (es)
SE (1) SE433621B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ190994A (en) 1978-07-24 1981-10-19 Merck & Co Inc Z-2-acylamino-3-monosubstituted propenoates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1483142A (en) * 1975-03-15 1977-08-17 Beecham Group Ltd Streptomycetal antibiotic
CH633554A5 (en) * 1975-11-21 1982-12-15 Merck & Co Inc Process for the preparation of novel thienamycin derivatives.

Also Published As

Publication number Publication date
DK487977A (da) 1978-05-18
JPS6310998B2 (es) 1988-03-10
SE7712430L (sv) 1978-05-18
PT67268B (en) 1979-10-08
JPS5363397A (en) 1978-06-06
CH634104A5 (en) 1983-01-14
FR2371448B1 (es) 1980-03-14
SE433621B (sv) 1984-06-04
DE2751303A1 (de) 1978-05-18
PT67268A (en) 1977-12-01
FR2371448A1 (fr) 1978-06-16
NL7712092A (nl) 1978-05-19
GB1595233A (en) 1981-08-12

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