CH626093A5 - - Google Patents

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Publication number
CH626093A5
CH626093A5 CH227476A CH227476A CH626093A5 CH 626093 A5 CH626093 A5 CH 626093A5 CH 227476 A CH227476 A CH 227476A CH 227476 A CH227476 A CH 227476A CH 626093 A5 CH626093 A5 CH 626093A5
Authority
CH
Switzerland
Prior art keywords
acid
organic
glycosides
groups
mmol
Prior art date
Application number
CH227476A
Other languages
German (de)
English (en)
Inventor
Helmut Dr Vorbrueggen
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of CH626093A5 publication Critical patent/CH626093A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
CH227476A 1975-02-24 1976-02-24 CH626093A5 (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19752508312 DE2508312A1 (de) 1975-02-24 1975-02-24 Neues verfahren zur herstellung von nucleosiden

Publications (1)

Publication Number Publication Date
CH626093A5 true CH626093A5 (id) 1981-10-30

Family

ID=5939872

Family Applications (1)

Application Number Title Priority Date Filing Date
CH227476A CH626093A5 (id) 1975-02-24 1976-02-24

Country Status (12)

Country Link
US (1) US4082911A (id)
JP (1) JPS51125382A (id)
BE (1) BE838879A (id)
CA (1) CA1065315A (id)
CH (1) CH626093A5 (id)
DE (1) DE2508312A1 (id)
DK (1) DK138900C (id)
FR (1) FR2301536A1 (id)
GB (1) GB1542442A (id)
LU (1) LU74411A1 (id)
NL (1) NL7601625A (id)
SE (1) SE7602109L (id)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53108986A (en) * 1977-03-02 1978-09-22 Mitsui Toatsu Chem Inc Preparation of nucleosides and nucleotides
DE2721466A1 (de) * 1977-05-12 1978-11-16 Robugen Gmbh Verfahren zur herstellung von 2'-desoxyribofuranosylnucleosiden
US4195176A (en) * 1977-10-11 1980-03-25 Warner-Lambert Company Imidazole compounds, methods for their production and conversion of said compounds into (R)-3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazol[4,5-d][1,3]diazepin-8-ol
DE2757365A1 (de) * 1977-12-20 1979-06-21 Schering Ag Neues verfahren zur herstellung von nucleosiden
JPH029511U (id) * 1988-06-21 1990-01-22
CA2091732C (en) * 1992-07-08 1998-07-21 Anica Markovac A process for the preparation of 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine
JPH07276137A (ja) * 1994-03-31 1995-10-24 Osaka Diamond Ind Co Ltd 切削・研削用工具
DE19513330A1 (de) * 1995-04-03 1996-10-10 Schering Ag Neues Verfahren zur Herstellung von Nucleosiden
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
CZ301182B6 (cs) 2000-05-26 2009-12-02 Idenix (Cayman) Limited Použití nukleosidových derivátu pro výrobu farmaceutických prostredku pro lécení infekcí vyvolaných flaviviry a pestiviry
AU2003248748A1 (en) 2002-06-28 2004-01-19 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
HUE033832T2 (en) 2002-11-15 2018-01-29 Idenix Pharmaceuticals Llc 2'-methyl nucleosides in combination with interferon and Flaviviridae mutation
US7038038B2 (en) * 2003-03-17 2006-05-02 Pharmion Corporation Synthesis of 5-azacytidine
US6887855B2 (en) 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
US6943249B2 (en) 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
KR20060015542A (ko) 2003-04-28 2006-02-17 이데닉스 (케이만) 리미티드 산업 규모의 뉴클레오시드 합성
JP2007527396A (ja) 2003-06-30 2007-09-27 イデニクス（ケイマン）リミテツド β−Ｌ−２’−デオキシヌクレオシドの合成
AT502635A1 (de) * 2005-11-09 2007-05-15 Saischek Und Partner Meg Neue 1,3-dithioverbindungen, verfahren zu deren herstellung und ihre verwendung
US7781576B2 (en) 2005-12-23 2010-08-24 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
EP2048151A1 (en) 2007-10-10 2009-04-15 Cilag AG Method for producing nucleosides by direct glycosylation of the nucleoside base
EP2050757A1 (en) * 2007-10-10 2009-04-22 Cilag AG Method of producing 2' -deoxy-5-azacytidine (Decitabine)
ES2712506T3 (es) 2008-05-15 2019-05-13 Celgene Corp Formulaciones orales de análogos de citidina y métodos de uso de los mismos
WO2010014883A2 (en) 2008-08-01 2010-02-04 Dr. Reddy's Laboratories Ltd. Azacitidine process and polymorphs
EP2324042B1 (en) * 2008-08-06 2012-11-28 Sicor, Inc. Process for preparing azacytidine intermediate
CN102216315B (zh) * 2008-08-08 2016-06-29 台湾神隆股份有限公司 制备5-氮杂胞嘧啶核苷和其衍生物的方法
WO2010129211A2 (en) * 2009-04-27 2010-11-11 Dr. Reddy's Laboratories Ltd. Preparation of decitabine
JP6289361B2 (ja) 2011-03-31 2018-03-07 セルジーン インターナショナル サルル ５−アザシチジンの合成
CN108239128B (zh) * 2016-12-23 2019-03-29 江苏奥赛康药业股份有限公司 β-核苷类化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3354160A (en) * 1965-07-22 1967-11-21 Hoffmann La Roche Tri-lower alkyl-silyl-5-fluoropyrimidines
US3352849A (en) * 1965-10-24 1967-11-14 Merck & Co Inc 6-aza-2'-deoxyuridines
CH541566A (de) * 1969-04-11 1973-09-15 Schering Ag Verfahren zur Herstellung von Nucleosiden
DE2122991C2 (de) * 1971-05-04 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von Cytosin- und 6-Azacytosinnucleosiden

Also Published As

Publication number Publication date
BE838879A (fr) 1976-08-24
NL7601625A (nl) 1976-08-26
DE2508312C2 (id) 1987-10-29
DK138900B (da) 1978-11-13
FR2301536B1 (id) 1979-07-27
LU74411A1 (id) 1976-08-13
FR2301536A1 (fr) 1976-09-17
US4082911A (en) 1978-04-04
JPS51125382A (en) 1976-11-01
DK138900C (da) 1979-04-30
GB1542442A (en) 1979-03-21
CA1065315A (en) 1979-10-30
JPS6139318B2 (id) 1986-09-03
DK77176A (da) 1976-08-25
SE7602109L (sv) 1976-08-25
DE2508312A1 (de) 1976-09-02

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