CH626093A5 - - Google Patents

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Publication number
CH626093A5
CH626093A5 CH227476A CH227476A CH626093A5 CH 626093 A5 CH626093 A5 CH 626093A5 CH 227476 A CH227476 A CH 227476A CH 227476 A CH227476 A CH 227476A CH 626093 A5 CH626093 A5 CH 626093A5
Authority
CH
Switzerland
Prior art keywords
acid
organic
glycosides
groups
mmol
Prior art date
Application number
CH227476A
Other languages
German (de)
English (en)
Inventor
Helmut Dr Vorbrueggen
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of CH626093A5 publication Critical patent/CH626093A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
CH227476A 1975-02-24 1976-02-24 CH626093A5 (forum.php)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19752508312 DE2508312A1 (de) 1975-02-24 1975-02-24 Neues verfahren zur herstellung von nucleosiden

Publications (1)

Publication Number Publication Date
CH626093A5 true CH626093A5 (forum.php) 1981-10-30

Family

ID=5939872

Family Applications (1)

Application Number Title Priority Date Filing Date
CH227476A CH626093A5 (forum.php) 1975-02-24 1976-02-24

Country Status (12)

Country Link
US (1) US4082911A (forum.php)
JP (1) JPS51125382A (forum.php)
BE (1) BE838879A (forum.php)
CA (1) CA1065315A (forum.php)
CH (1) CH626093A5 (forum.php)
DE (1) DE2508312A1 (forum.php)
DK (1) DK138900C (forum.php)
FR (1) FR2301536A1 (forum.php)
GB (1) GB1542442A (forum.php)
LU (1) LU74411A1 (forum.php)
NL (1) NL7601625A (forum.php)
SE (1) SE7602109L (forum.php)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53108986A (en) * 1977-03-02 1978-09-22 Mitsui Toatsu Chem Inc Preparation of nucleosides and nucleotides
DE2721466A1 (de) * 1977-05-12 1978-11-16 Robugen Gmbh Verfahren zur herstellung von 2'-desoxyribofuranosylnucleosiden
US4195176A (en) * 1977-10-11 1980-03-25 Warner-Lambert Company Imidazole compounds, methods for their production and conversion of said compounds into (R)-3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazol[4,5-d][1,3]diazepin-8-ol
DE2757365A1 (de) * 1977-12-20 1979-06-21 Schering Ag Neues verfahren zur herstellung von nucleosiden
JPH029511U (forum.php) * 1988-06-21 1990-01-22
ZA923641B (en) * 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
CA2091732C (en) * 1992-07-08 1998-07-21 Anica Markovac A process for the preparation of 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine
JPH07276137A (ja) * 1994-03-31 1995-10-24 Osaka Diamond Ind Co Ltd 切削・研削用工具
DE19513330A1 (de) * 1995-04-03 1996-10-10 Schering Ag Neues Verfahren zur Herstellung von Nucleosiden
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
WO2001092282A2 (en) 2000-05-26 2001-12-06 Idenix (Cayman) Limited Methods and compositions for treating flaviviruses and pestiviruses
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
NZ537662A (en) 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
CN1678326A (zh) 2002-06-28 2005-10-05 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2'－c－甲基－3'－o－l－缬氨酸酯核糖呋喃基胞苷
DK1576138T3 (en) 2002-11-15 2017-05-01 Idenix Pharmaceuticals Llc 2'-METHYL NUCLEOSIDES IN COMBINATION WITH INTERFERON AND FLAVIVIRIDAE MUTATION
WO2004052899A2 (en) 2002-12-12 2004-06-24 Idenix (Cayman) Limited Process for the production of 2'-branched nucleosides
US6943249B2 (en) * 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
US7038038B2 (en) * 2003-03-17 2006-05-02 Pharmion Corporation Synthesis of 5-azacytidine
US6887855B2 (en) 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
WO2004096149A2 (en) 2003-04-28 2004-11-11 Idenix (Cayman) Limited Industrially scalable nucleoside synthesis
CA2531412A1 (en) 2003-06-30 2005-01-13 Idenix (Cayman) Limited Synthesis of .beta.-l-2'-deoxy nucleosides
AT502635A1 (de) * 2005-11-09 2007-05-15 Saischek Und Partner Meg Neue 1,3-dithioverbindungen, verfahren zu deren herstellung und ihre verwendung
CA2634749C (en) 2005-12-23 2014-08-19 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
EP2050757A1 (en) * 2007-10-10 2009-04-22 Cilag AG Method of producing 2' -deoxy-5-azacytidine (Decitabine)
EP2048151A1 (en) * 2007-10-10 2009-04-15 Cilag AG Method for producing nucleosides by direct glycosylation of the nucleoside base
ES2969144T3 (es) 2008-05-15 2024-05-16 Celgene Corp Formulaciones orales de análogos de citidina y métodos de uso de los mismos
WO2010014883A2 (en) 2008-08-01 2010-02-04 Dr. Reddy's Laboratories Ltd. Azacitidine process and polymorphs
WO2010017374A1 (en) * 2008-08-06 2010-02-11 Sicor Inc. Process for preparing azacytidine intermediate
CA2733591C (en) * 2008-08-08 2016-06-28 Scinopharm Taiwan Ltd. Process for making 5-azacytosine nucleosides and their derivatives
EP2424845A4 (en) * 2009-04-27 2014-03-05 Reddys Lab Ltd Dr PREPARATION OF DECITABIN
SG193622A1 (en) 2011-03-31 2013-11-29 Celgene Internat Sarl Systhesis of 5-azacytidine
CN108239128B (zh) * 2016-12-23 2019-03-29 江苏奥赛康药业股份有限公司 β-核苷类化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3354160A (en) * 1965-07-22 1967-11-21 Hoffmann La Roche Tri-lower alkyl-silyl-5-fluoropyrimidines
US3352849A (en) * 1965-10-24 1967-11-14 Merck & Co Inc 6-aza-2'-deoxyuridines
SU452961A3 (ru) * 1969-04-11 1974-12-05 Шеринг Аг. (Фирма) Способ получени пиримидиннуклеозидов
DE2122991C2 (de) * 1971-05-04 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von Cytosin- und 6-Azacytosinnucleosiden

Also Published As

Publication number Publication date
DE2508312A1 (de) 1976-09-02
JPS51125382A (en) 1976-11-01
CA1065315A (en) 1979-10-30
FR2301536B1 (forum.php) 1979-07-27
SE7602109L (sv) 1976-08-25
LU74411A1 (forum.php) 1976-08-13
NL7601625A (nl) 1976-08-26
DE2508312C2 (forum.php) 1987-10-29
GB1542442A (en) 1979-03-21
FR2301536A1 (fr) 1976-09-17
DK138900C (da) 1979-04-30
US4082911A (en) 1978-04-04
JPS6139318B2 (forum.php) 1986-09-03
DK138900B (da) 1978-11-13
DK77176A (da) 1976-08-25
BE838879A (fr) 1976-08-24

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