CH614931A5 - - Google Patents

Info

Publication number
CH614931A5
CH614931A5 CH1419575A CH1419575A CH614931A5 CH 614931 A5 CH614931 A5 CH 614931A5 CH 1419575 A CH1419575 A CH 1419575A CH 1419575 A CH1419575 A CH 1419575A CH 614931 A5 CH614931 A5 CH 614931A5
Authority
CH
Switzerland
Application number
CH1419575A
Inventor
Artur Dr Rueegger
Max Kuhn
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Priority to CH1419575A priority Critical patent/CH614931A5/xx
Priority to DE2661031A priority patent/DE2661031C2/de
Priority to DE2648121A priority patent/DE2648121C2/de
Priority to ZA00766340A priority patent/ZA766340B/xx
Priority to DK483176A priority patent/DK148907C/da
Priority to FI763049A priority patent/FI60701C/fi
Priority to US05/736,106 priority patent/US4108985A/en
Priority to SE7611906A priority patent/SE432247B/xx
Priority to NO763667A priority patent/NO763667L/no
Priority to NL7612026A priority patent/NL7612026A/xx
Priority to NZ182496A priority patent/NZ182496A/xx
Priority to AU19262/76A priority patent/AU513538B2/en
Priority to PH19079A priority patent/PH14725A/en
Priority to IE2379/81A priority patent/IE44750B1/en
Priority to GB19922/79A priority patent/GB1567202A/en
Priority to IE2439/76A priority patent/IE44749B1/en
Priority to GB45485/76A priority patent/GB1567201A/en
Priority to JP51131314A priority patent/JPS5259180A/ja
Priority to CA264,703A priority patent/CA1087609A/en
Priority to PT65791A priority patent/PT65791B/pt
Priority to ES452942A priority patent/ES452942A1/es
Priority to YU02700/76A priority patent/YU270076A/xx
Priority to AT812276A priority patent/AT359642B/de
Priority to IL50836A priority patent/IL50836A/xx
Priority to BE172045A priority patent/BE847941A/xx
Priority to FR7633231A priority patent/FR2330387A1/fr
Priority to FR7711993A priority patent/FR2338251A1/fr
Priority to US05/914,118 priority patent/US4210581A/en
Priority to AT0768178A priority patent/AT364453B/de
Priority to CH543479A priority patent/CH619735A5/de
Priority to NZ191876A priority patent/NZ191876A/xx
Publication of CH614931A5 publication Critical patent/CH614931A5/xx
Priority to CA353,123A priority patent/CA1106303A/en
Priority to FI802084A priority patent/FI60718C/fi
Priority to SE8202039A priority patent/SE8202039L/sv
Priority to DK277085A priority patent/DK277085A/da
Priority to JP61215602A priority patent/JPS6277399A/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/885—Trichoderma
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein
CH1419575A 1975-11-04 1975-11-04 CH614931A5 (ja)

Priority Applications (36)

Application Number Priority Date Filing Date Title
CH1419575A CH614931A5 (ja) 1975-11-04 1975-11-04
DE2661031A DE2661031C2 (ja) 1975-11-04 1976-10-23
DE2648121A DE2648121C2 (de) 1975-11-04 1976-10-23 Dihydro-cyclosporin C, Verfahren zu dessen Herstellung und diese Verbindung enthaltende Arzneimittel
ZA00766340A ZA766340B (en) 1975-11-04 1976-10-25 Improvements in or relating to organic compounds
DK483176A DK148907C (da) 1975-11-04 1976-10-26 Analogifremgangsmaade til fremstilling af dihydrocyclosporin c
FI763049A FI60701C (fi) 1975-11-04 1976-10-26 Foerfarande foer framstaellning av terapeutiskt anvaendbar dihydrocyklosporin c
US05/736,106 US4108985A (en) 1975-11-04 1976-10-27 Dihydrocyclosporin c
SE7611906A SE432247B (sv) 1975-11-04 1976-10-27 Sett att framstella dihydro-cyklosporin c
NO763667A NO763667L (ja) 1975-11-04 1976-10-27
NL7612026A NL7612026A (nl) 1975-11-04 1976-10-29 Werkwijzen voor het bereiden en toepassen van een cyclisch amidederivaat.
JP51131314A JPS5259180A (en) 1975-11-04 1976-11-02 Improving concerning organic compound
AU19262/76A AU513538B2 (en) 1975-11-04 1976-11-02 Dihydrocyclosporin c and cyclosporin c
PH19079A PH14725A (en) 1975-11-04 1976-11-02 A cyclosporin derivative
IE2379/81A IE44750B1 (en) 1975-11-04 1976-11-02 Cyclosporin c
GB19922/79A GB1567202A (en) 1975-11-04 1976-11-02 Sandoz ltd
IE2439/76A IE44749B1 (en) 1975-11-04 1976-11-02 Dihydrocyclosporin c
GB45485/76A GB1567201A (en) 1975-11-04 1976-11-02 Sandoz ltd
NZ182496A NZ182496A (en) 1975-11-04 1976-11-02 Cyclosporin c from tolypocladium inflatum gams or cylindrocarpon lucidum booth dihydrocyclosporin c
CA264,703A CA1087609A (en) 1975-11-04 1976-11-02 Dihydrocyclosporin c
IL50836A IL50836A (en) 1975-11-04 1976-11-03 Dihydrocyclosphorin c,a process for the preparation thereoof and pharmaceutical compositions containing this compound
ES452942A ES452942A1 (es) 1975-11-04 1976-11-03 Procedimiento para la produccion de dihidrociclosporina c.
YU02700/76A YU270076A (en) 1975-11-04 1976-11-03 Process for preparing new organic compunds
AT812276A AT359642B (de) 1975-11-04 1976-11-03 Verfahren zur herstellung eines neuen ring- peptids
PT65791A PT65791B (fr) 1975-11-04 1976-11-03 Procede pour la preparation de nouveaux composes organiques a effet pharmaceutique
BE172045A BE847941A (fr) 1975-11-04 1976-11-03 Nouveau compose peptidique, sa preparation et son application comme medicament
FR7633231A FR2330387A1 (fr) 1975-11-04 1976-11-04 Nouveau compose peptidique, sa preparation et son application comme medicament
FR7711993A FR2338251A1 (fr) 1975-11-04 1977-04-21 Nouveau compose peptidique et sa preparation
US05/914,118 US4210581A (en) 1975-11-04 1978-06-09 Organic compounds
AT0768178A AT364453B (de) 1975-11-04 1978-10-27 Verfahren zur herstellung eines neuen ringpeptids
CH543479A CH619735A5 (ja) 1975-11-04 1979-06-11
NZ191876A NZ191876A (en) 1975-11-04 1979-10-18 Cyclosporin c and its preparation
CA353,123A CA1106303A (en) 1975-11-04 1980-05-30 Cyclosporin c from tolypocladium or cylindrocarbon
FI802084A FI60718C (fi) 1975-11-04 1980-06-30 En ny ringpeptid cyklosporin c anvaendbar som mellanprodukt vid framstaellning av dihydrocyklosporin c och ett foerfarande foer dess framstaellning
SE8202039A SE8202039L (sv) 1975-11-04 1982-03-30 Cyklosporin c och sett att framstella denna forening
DK277085A DK277085A (da) 1975-11-04 1985-06-19 Mellemprodukt til anvendelse ved fremstilling af dihydrocyclosporin c
JP61215602A JPS6277399A (ja) 1975-11-04 1986-09-11 シクロスポリンｃ

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1419575A CH614931A5 (ja) 1975-11-04 1975-11-04

Publications (1)

Publication Number Publication Date
CH614931A5 true CH614931A5 (ja) 1979-12-28

Family

ID=4398730

Family Applications (2)

Application Number Title Priority Date Filing Date
CH1419575A CH614931A5 (ja) 1975-11-04 1975-11-04
CH543479A CH619735A5 (ja) 1975-11-04 1979-06-11

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH543479A CH619735A5 (ja) 1975-11-04 1979-06-11

Country Status (23)

Country Link
US (1) US4108985A (ja)
JP (2) JPS5259180A (ja)
AT (1) AT359642B (ja)
AU (1) AU513538B2 (ja)
BE (1) BE847941A (ja)
CA (1) CA1087609A (ja)
CH (2) CH614931A5 (ja)
DE (2) DE2661031C2 (ja)
DK (1) DK148907C (ja)
ES (1) ES452942A1 (ja)
FI (1) FI60701C (ja)
FR (2) FR2330387A1 (ja)
GB (2) GB1567202A (ja)
IE (2) IE44749B1 (ja)
IL (1) IL50836A (ja)
NL (1) NL7612026A (ja)
NO (1) NO763667L (ja)
NZ (1) NZ182496A (ja)
PH (1) PH14725A (ja)
PT (1) PT65791B (ja)
SE (2) SE432247B (ja)
YU (1) YU270076A (ja)
ZA (1) ZA766340B (ja)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4210581A (en) * 1975-11-04 1980-07-01 Sandoz Ltd. Organic compounds
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
FR2410658A1 (fr) * 1977-11-30 1979-06-29 Science Union & Cie Nouveau produit biologique d'origine fongique, son obtention et son application a la therapeutique
FI65914C (fi) * 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
SE448386B (sv) * 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
US4201771A (en) * 1979-03-12 1980-05-06 Merck & Co., Inc. Antibiotic A43F
JPS5665853A (en) * 1979-11-01 1981-06-03 Sankyo Co Ltd Mycoplanesin derivative and its preparation
US4396542A (en) * 1980-02-14 1983-08-02 Sandoz Ltd. Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
EP0098456B1 (en) * 1980-02-14 1989-05-24 Sandoz Ag Peptides comprising a (1s,2r,3r)- or (1r,2s,3s)-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptane or -hept-5-ene residue useful in the total synthesis of cyclosporins, and processes for their production
US4370266A (en) * 1980-04-07 1983-01-25 Sankyo Company, Limited Mycoplanecin derivatives and their preparation
DE3260468D1 (en) * 1981-01-09 1984-09-06 Sandoz Ag Novel cyclosporins
US5639724A (en) * 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
GB8422253D0 (en) * 1984-09-04 1984-10-10 Sandoz Ltd Organic compounds
EP0198026B1 (en) * 1984-10-04 1993-08-04 Sandoz Ag Monoclonal antibodies to cyclosporings
US4727035A (en) * 1984-11-14 1988-02-23 Mahoney Walter C Immunoassay for cyclosporin
US4764503A (en) * 1986-11-19 1988-08-16 Sandoz Ltd. Novel cyclosporins
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
ATE95193T1 (de) * 1987-06-17 1993-10-15 Sandoz Ag Cyclosporine und deren benutzung als arzneimittel.
EP0373260B1 (en) * 1987-06-22 1994-03-09 Merck & Co. Inc. Cyclosporin derivatives with modified "8-amino acid"
GB8717299D0 (en) * 1987-07-22 1987-08-26 Nat Res Dev Peptides
GB8717300D0 (en) * 1987-07-22 1987-08-26 Nat Res Dev Cyclosporins
US5227467A (en) * 1987-08-03 1993-07-13 Merck & Co., Inc. Immunosuppressive fluorinated cyclosporin analogs
KR920003601B1 (ko) * 1987-09-03 1992-05-04 유니버시티 어브 죠지아 리서취 화운데이션 인코포레이티드 점안 싸이클로스포린(cyclosporin)의 조성물
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
US5236899A (en) * 1987-11-16 1993-08-17 Merck & Co., Inc. 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance
US4914188A (en) * 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
HU203564B (en) * 1987-12-21 1991-08-28 Sandoz Ag Process for producing new orthorombos cyclosporin without solvatation
US4943560A (en) * 1988-04-06 1990-07-24 Regents Of The University Of Minnesota Solvent system for chronic vascular infusion of hydrophobic drugs
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
US7081445B2 (en) * 1989-02-20 2006-07-25 Novartis Ag Cyclosporin galenic forms
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
DE69222150T2 (de) * 1991-01-25 1998-01-15 Fujisawa Pharmaceutical Co Prozess zur produktion von cyclosporin-a und/oder c
ES2065273B1 (es) * 1993-05-25 1995-09-16 Biogal Gyogyszergyar Procedimiento para la purificacion de ciclosporina a.
US5709797A (en) * 1996-06-05 1998-01-20 Poli Industria Chimica S.P.A. Method of isolating cyclosporins
RU2211047C2 (ru) 1997-01-30 2003-08-27 Новартис Аг Желатиновые капсулы с твердым покрытием, включающие фармацевтические композиции, практически не содержащие масел
IN188719B (ja) * 1997-09-08 2002-11-02 Panacea Biotec Ltd
US6008191A (en) * 1997-09-08 1999-12-28 Panacea Biotec Limited Pharmaceutical compositions containing cyclosporin
US6346511B1 (en) 1997-09-08 2002-02-12 Panacea Biotec Limited Pharmaceutical composition comprising cyclosporin
US6187747B1 (en) 1997-09-08 2001-02-13 Panacea Biotech Limited Pharmaceutical composition comprising cyclosporin
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
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ES2255275T3 (es) 1998-07-01 2006-06-16 Debiopharm S.A. Nueva ciclosporina con perfil de actividad mejorado.
EP1435910B9 (en) * 2001-10-19 2010-02-03 Isotechnika Inc. Novel cyclosporin analog microemulsion preconcentrates
DE60213115T2 (de) 2001-10-19 2007-02-01 Isotechnika, Inc., Edmonton Synthese von cyclosporinanaloga
US20060014677A1 (en) * 2004-07-19 2006-01-19 Isotechnika International Inc. Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds
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EP1809656A4 (en) 2004-09-29 2009-03-25 Amr Technology Inc CYCLOSPORINAL KINANALOGA AND ITS PHARMACEUTICAL APPLICATIONS
EP1812037A4 (en) 2004-10-06 2009-11-11 Amr Technology Inc ALKYNES OF CYCLOSPORINE AND THEIR USEFUL AS PHARMACEUTICAL AGENTS
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US10137083B2 (en) * 2006-03-07 2018-11-27 SGN Nanopharma Inc Ophthalmic preparations
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TW200932240A (en) 2007-10-25 2009-08-01 Astellas Pharma Inc Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production
BRPI1007476A2 (pt) * 2009-01-30 2016-02-16 Enanta Pharm Inc análogos de ciclosporina para prevenir ou tratar infecção por hepatite c
US8481483B2 (en) * 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8685917B2 (en) * 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8349312B2 (en) * 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
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Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2463138C2 (de) * 1973-12-06 1984-07-05 Sandoz-Patent-GmbH, 7850 Lörrach Das Antibiotikum Cyclosporin B (S 7481/F-2), seine Herstellung und Verwendung

Also Published As

Publication number Publication date
IE44749B1 (en) 1982-03-24
AU513538B2 (en) 1980-12-11
NZ182496A (en) 1981-12-15
ES452942A1 (es) 1978-01-16
FR2330387B1 (ja) 1980-03-14
YU270076A (en) 1982-05-31
IE44750B1 (en) 1982-03-24
FR2330387A1 (fr) 1977-06-03
SE7611906L (sv) 1977-05-05
US4108985A (en) 1978-08-22
PH14725A (en) 1981-11-13
FI60701C (fi) 1982-03-10
DE2648121C2 (de) 1986-05-28
FI60701B (fi) 1981-11-30
DE2648121A1 (de) 1977-05-12
NL7612026A (nl) 1977-05-06
AU1926276A (en) 1978-05-11
SE432247B (sv) 1984-03-26
PT65791A (fr) 1976-12-01
IL50836A (en) 1979-10-31
BE847941A (fr) 1977-05-03
GB1567202A (en) 1980-05-14
FR2338251A1 (fr) 1977-08-12
SE8202039L (sv) 1982-03-30
AT359642B (de) 1980-11-25
DK148907C (da) 1986-04-07
IE44750L (en) 1977-05-04
JPS6210240B2 (ja) 1987-03-05
PT65791B (fr) 1978-07-05
GB1567201A (en) 1980-05-14
IL50836A0 (en) 1977-01-31
DK148907B (da) 1985-11-11
NO763667L (ja) 1977-05-05
DE2661031C2 (ja) 1988-05-05
JPS5259180A (en) 1977-05-16
FI763049A (ja) 1977-05-05
JPS6253520B2 (ja) 1987-11-10
DK483176A (da) 1977-05-05
CH619735A5 (ja) 1980-10-15
IE44749L (en) 1977-05-04
ZA766340B (en) 1978-06-28
FR2338251B1 (ja) 1984-01-13
ATA812276A (de) 1980-04-15
JPS6277399A (ja) 1987-04-09
CA1087609A (en) 1980-10-14

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