SE8202039L - Cyklosporin c och sett att framstella denna forening - Google Patents

Cyklosporin c och sett att framstella denna forening

Info

Publication number
SE8202039L
SE8202039L SE8202039A SE8202039A SE8202039L SE 8202039 L SE8202039 L SE 8202039L SE 8202039 A SE8202039 A SE 8202039A SE 8202039 A SE8202039 A SE 8202039A SE 8202039 L SE8202039 L SE 8202039L
Authority
SE
Sweden
Prior art keywords
cyclosporin
substance
make
dihydrocyclosporin
kummelsten
Prior art date
Application number
SE8202039A
Other languages
English (en)
Inventor
A Ruegger
M Kuhn
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of SE8202039L publication Critical patent/SE8202039L/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/885—Trichoderma
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Claims (2)

PATENTKRAV
1. Cyklosporin C (formal 11) (21)Ans nr 8202039-7 Rotel 8131 (51)Klass C 07 C 103/52 C 12 P 21/04 (74)0mbud Kummelsten P CO CH, \CH-C H2- H CH3/ C113-14 o XI C. cn3,, 7.c. .H3HO CCC'' c • 3 7-3 7, 7, Cu C3 1 Cu-OH CH3 CH3-N-C H-CO-N— N —CH— CO —N —CH—C— N—CH2 II 0III 0 II,Li , i
2. L 0._ C.—N ---CO-C I-1—N —C 0 —CH —N—C—CH—N-CO—CH IIIIIII CH CH3 HCH3CH2 CH3 .......„CH2 I CHC/-13 CO3I CH3C '..CH3.....S11, H3 CH3 CO N-CH, till anvandning sore rnellanp-t for framstallnieldihydro-cyklosporin C.
SE8202039A 1975-11-04 1982-03-30 Cyklosporin c och sett att framstella denna forening SE8202039L (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1419575A CH614931A5 (sv) 1975-11-04 1975-11-04

Publications (1)

Publication Number Publication Date
SE8202039L true SE8202039L (sv) 1982-03-30

Family

ID=4398730

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7611906A SE432247B (sv) 1975-11-04 1976-10-27 Sett att framstella dihydro-cyklosporin c
SE8202039A SE8202039L (sv) 1975-11-04 1982-03-30 Cyklosporin c och sett att framstella denna forening

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7611906A SE432247B (sv) 1975-11-04 1976-10-27 Sett att framstella dihydro-cyklosporin c

Country Status (23)

Country Link
US (1) US4108985A (sv)
JP (2) JPS5259180A (sv)
AT (1) AT359642B (sv)
AU (1) AU513538B2 (sv)
BE (1) BE847941A (sv)
CA (1) CA1087609A (sv)
CH (2) CH614931A5 (sv)
DE (2) DE2648121C2 (sv)
DK (1) DK148907C (sv)
ES (1) ES452942A1 (sv)
FI (1) FI60701C (sv)
FR (2) FR2330387A1 (sv)
GB (2) GB1567202A (sv)
IE (2) IE44749B1 (sv)
IL (1) IL50836A (sv)
NL (1) NL7612026A (sv)
NO (1) NO763667L (sv)
NZ (1) NZ182496A (sv)
PH (1) PH14725A (sv)
PT (1) PT65791B (sv)
SE (2) SE432247B (sv)
YU (1) YU270076A (sv)
ZA (1) ZA766340B (sv)

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FI65914C (fi) * 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
SE448386B (sv) * 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
US4201771A (en) * 1979-03-12 1980-05-06 Merck & Co., Inc. Antibiotic A43F
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US4396542A (en) * 1980-02-14 1983-08-02 Sandoz Ltd. Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
DE3167014D1 (en) * 1980-02-14 1984-12-13 Sandoz Ag A method for the total synthesis of cyclosporins and novel cyclosporins
US4370266A (en) * 1980-04-07 1983-01-25 Sankyo Company, Limited Mycoplanecin derivatives and their preparation
DE3260468D1 (en) * 1981-01-09 1984-09-06 Sandoz Ag Novel cyclosporins
US5639724A (en) 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
GB8422253D0 (en) * 1984-09-04 1984-10-10 Sandoz Ltd Organic compounds
ATE92501T1 (de) 1984-10-04 1993-08-15 Sandoz Ag Monoklonale antikoerper gegen zyklosporine.
US4727035A (en) * 1984-11-14 1988-02-23 Mahoney Walter C Immunoassay for cyclosporin
US4764503A (en) * 1986-11-19 1988-08-16 Sandoz Ltd. Novel cyclosporins
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US5227467A (en) * 1987-08-03 1993-07-13 Merck & Co., Inc. Immunosuppressive fluorinated cyclosporin analogs
DE3851152T2 (de) * 1987-09-03 1995-01-26 Univ Georgia Res Found Cyclosporin-augenmittel.
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
US4914188A (en) * 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
US5236899A (en) * 1987-11-16 1993-08-17 Merck & Co., Inc. 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance
HU203564B (en) * 1987-12-21 1991-08-28 Sandoz Ag Process for producing new orthorombos cyclosporin without solvatation
US4943560A (en) * 1988-04-06 1990-07-24 Regents Of The University Of Minnesota Solvent system for chronic vascular infusion of hydrophobic drugs
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
US7081445B2 (en) * 1989-02-20 2006-07-25 Novartis Ag Cyclosporin galenic forms
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
EP0568698B1 (en) * 1991-01-25 1997-09-10 Fujisawa Pharmaceutical Co., Ltd. Process for producing cyclosporin a and/or c
ES2065273B1 (es) * 1993-05-25 1995-09-16 Biogal Gyogyszergyar Procedimiento para la purificacion de ciclosporina a.
US5709797A (en) * 1996-06-05 1998-01-20 Poli Industria Chimica S.P.A. Method of isolating cyclosporins
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US6008191A (en) * 1997-09-08 1999-12-28 Panacea Biotec Limited Pharmaceutical compositions containing cyclosporin
IN188719B (sv) * 1997-09-08 2002-11-02 Panacea Biotec Ltd
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
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Also Published As

Publication number Publication date
DK148907B (da) 1985-11-11
PH14725A (en) 1981-11-13
SE7611906L (sv) 1977-05-05
SE432247B (sv) 1984-03-26
NO763667L (sv) 1977-05-05
DE2648121A1 (de) 1977-05-12
IE44749L (en) 1977-05-04
CH619735A5 (sv) 1980-10-15
NL7612026A (nl) 1977-05-06
ES452942A1 (es) 1978-01-16
DK148907C (da) 1986-04-07
CH614931A5 (sv) 1979-12-28
IE44750B1 (en) 1982-03-24
BE847941A (fr) 1977-05-03
FI763049A (sv) 1977-05-05
AT359642B (de) 1980-11-25
PT65791A (fr) 1976-12-01
CA1087609A (en) 1980-10-14
GB1567201A (en) 1980-05-14
YU270076A (en) 1982-05-31
AU513538B2 (en) 1980-12-11
DK483176A (da) 1977-05-05
US4108985A (en) 1978-08-22
IL50836A (en) 1979-10-31
FR2330387B1 (sv) 1980-03-14
ATA812276A (de) 1980-04-15
IE44750L (en) 1977-05-04
ZA766340B (en) 1978-06-28
DE2648121C2 (de) 1986-05-28
FI60701B (fi) 1981-11-30
FR2338251B1 (sv) 1984-01-13
FI60701C (fi) 1982-03-10
FR2330387A1 (fr) 1977-06-03
AU1926276A (en) 1978-05-11
GB1567202A (en) 1980-05-14
IL50836A0 (en) 1977-01-31
PT65791B (fr) 1978-07-05
JPS6277399A (ja) 1987-04-09
JPS6210240B2 (sv) 1987-03-05
JPS6253520B2 (sv) 1987-11-10
NZ182496A (en) 1981-12-15
FR2338251A1 (fr) 1977-08-12
JPS5259180A (en) 1977-05-16
IE44749B1 (en) 1982-03-24
DE2661031C2 (sv) 1988-05-05

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