CH440310A - Verfahren zur Herstellung eines neuen Nonapeptidamids - Google Patents
Verfahren zur Herstellung eines neuen NonapeptidamidsInfo
- Publication number
- CH440310A CH440310A CH386362A CH386362A CH440310A CH 440310 A CH440310 A CH 440310A CH 386362 A CH386362 A CH 386362A CH 386362 A CH386362 A CH 386362A CH 440310 A CH440310 A CH 440310A
- Authority
- CH
- Switzerland
- Prior art keywords
- isoleucyl
- cysteinyl
- benzyl
- carbobenzyloxy
- prolyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 26
- 150000001408 amides Chemical class 0.000 title claims description 17
- 238000002360 preparation method Methods 0.000 title claims description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 53
- -1 aralkyl ester Chemical class 0.000 claims description 27
- 229960000583 acetic acid Drugs 0.000 claims description 25
- 229910052717 sulfur Inorganic materials 0.000 claims description 23
- 239000012362 glacial acetic acid Substances 0.000 claims description 22
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- 239000001257 hydrogen Substances 0.000 claims description 6
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- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 claims description 5
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- 210000004899 c-terminal region Anatomy 0.000 claims description 5
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- 238000010992 reflux Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000008259 solid foam Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- DKACXUFSLUYRFU-UHFFFAOYSA-N tert-butyl n-aminocarbamate Chemical compound CC(C)(C)OC(=O)NN DKACXUFSLUYRFU-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- BQMKAHQKDSZAIQ-UHFFFAOYSA-N tetrasodium;iron(3+);nitroxyl anion;pentacyanide Chemical compound [Na+].[Na+].[Na+].[Na+].[Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].O=[N-] BQMKAHQKDSZAIQ-UHFFFAOYSA-N 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/16—Oxytocins; Vasopressins; Related peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/15—Oxytocin or vasopressin; related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH386362A CH440310A (de) | 1962-03-30 | 1962-03-30 | Verfahren zur Herstellung eines neuen Nonapeptidamids |
| GB2408/66A GB1033906A (en) | 1962-03-30 | 1963-03-22 | Process for the production of a new tetrapeptide |
| GB2407/66A GB1033905A (en) | 1962-03-30 | 1963-03-22 | Process for the production of a new pentapeptide |
| GB11375/63A GB1033904A (en) | 1962-03-30 | 1963-03-22 | Process for the production of a new nonapeptidamide |
| US267772A US3296243A (en) | 1962-03-30 | 1963-03-25 | Process for the production of ser4-ile8-oxytocin and intermediates therein |
| SE3490/63A SE322229B (en:Method) | 1962-03-30 | 1963-03-29 | |
| FI0577/63A FI40901B (en:Method) | 1962-03-30 | 1963-03-29 | |
| BE630332A BE630332A (en:Method) | 1962-03-30 | 1963-03-29 | |
| ES286566A ES286566A1 (es) | 1962-03-30 | 1963-03-29 | Procedimiento para preparar ser-4-ile8-oxitocina (s, s¿-dehidro-1-cisteinil-1-tirosil-isoleucil-1-seril-1-asparaginil-1-cisteinil-1-prolil-1-isoleucil-glicinamida) |
| FR939708A FR3565M (fr) | 1962-03-30 | 1963-06-28 | Médicament a base d'un nonapeptide-amide cyclique. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH386362A CH440310A (de) | 1962-03-30 | 1962-03-30 | Verfahren zur Herstellung eines neuen Nonapeptidamids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH440310A true CH440310A (de) | 1967-07-31 |
Family
ID=4265082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH386362A CH440310A (de) | 1962-03-30 | 1962-03-30 | Verfahren zur Herstellung eines neuen Nonapeptidamids |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US3296243A (en:Method) |
| CH (1) | CH440310A (en:Method) |
| FI (1) | FI40901B (en:Method) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3723406A (en) * | 1969-12-23 | 1973-03-27 | Squibb & Sons Inc | Novel peptides having cholecystokinin activity and intermediates therefor |
| US5707965A (en) * | 1974-11-14 | 1998-01-13 | Intesco Laboratories, Inc. | Peptides for control of intestinal motility |
| US5225528A (en) * | 1990-02-27 | 1993-07-06 | Merck & Co., Inc. | Cyclic hexapeptide oxytocin antagonists |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2854443A (en) * | 1955-10-12 | 1958-09-30 | Saul & Co | Alyl-oxytocin and process for the preparation thereof |
-
1962
- 1962-03-30 CH CH386362A patent/CH440310A/de unknown
-
1963
- 1963-03-25 US US267772A patent/US3296243A/en not_active Expired - Lifetime
- 1963-03-29 FI FI0577/63A patent/FI40901B/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| FI40901B (en:Method) | 1969-03-31 |
| US3296243A (en) | 1967-01-03 |
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