CH247163A - Process for the production of a new preparation containing caffeine. - Google Patents

Process for the production of a new preparation containing caffeine.

Info

Publication number
CH247163A
CH247163A CH247163DA CH247163A CH 247163 A CH247163 A CH 247163A CH 247163D A CH247163D A CH 247163DA CH 247163 A CH247163 A CH 247163A
Authority
CH
Switzerland
Prior art keywords
solution
production
acid
caffeine
preparation containing
Prior art date
Application number
Other languages
German (de)
Inventor
Adrien Dr Med Schoch
Original Assignee
Adrien Dr Med Schoch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adrien Dr Med Schoch filed Critical Adrien Dr Med Schoch
Publication of CH247163A publication Critical patent/CH247163A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/12—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1, 3, and 7, e.g. caffeine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Herstellung eines neuen     coffeinhaltigen    Präparates.    Im Hauptpatent ist ein Verfahren zur  Herstellung eines neuen     coffeinhaltigen    Prä  parates beschrieben, gemäss welchem man  eine     ss-Naphthylfettsäure    mit Natronlauge  neutralisiert, bis die Lösung einen     p11-Wert     von 8,5 aufweist, der Lösung dann     Coffein     in einer Gewichtsmenge zusetzt, die wenig  stens annähernd gleich ist dem Gewicht der  angewendeten Säure, worauf man durch wei  teren Zusatz von     ss-Naphthylfettsäure    die  Lösung genau auf den     Neutralpunkt    einstellt  und zur Trockne verdampft.  



  Es wurde nun gefunden, dass man zu  einem therapeutisch gleichwertigen     coffein-          ha.ltigen    Präparat gelangt, wenn man eine       ss-Inclolylfettsäure,    z. B.     ss-Indoly        lessigsäure,          ss    -     Indolylpropionsäure.        ss    -     Indolylvalerian-          säure,        ss-Indolylbuttersäure,    mit Natronlauge  neutralisiert, bis die Lösung einen     pH-Wert     von 8,5     aufweist,    der Lösung     Coffein    in  einer Gewichtsmenge zusetzt,

   die wenigstens  annähernd gleich ist dem Gewicht der ange  wendeten Säure, und darauf durch weiteren  Zusatz von     ss-Indolylfettsäure    die Lösung       ,genau    auf den     Neutralpunkt    einstellt und zur       Troekne    verdampft.    <I>Beispiel:</I>    30 g zweimal aus Benzol umkristallisier  ter     ss-Indolylessigsäurewerden    in der berech  neten Menge In Natronlauge gelöst.

   Die     er-          haltene    Lösung ist noch stark alkalisch und  wird mit weiteren     3-4    g     ss-Indolylessigsäure       versetzt, wobei ein     pH-Wert    von 8,5 erreicht       wird.    Dann werden der Lösung 33-34     g          Coffein    zugesetzt, wodurch sich der     pH-Wert     kaum ändert. Durch Zugabe von zirka 1/2 g       ss-Indolylessigsäure    wird der     pH-Wert    der  Lösung genau an den     Neutralpunkt    gebracht.

    Dann erfolgt     Eindampfen    der Lösung zur  Trockne im     Vakuumexsikkator    über konzen  trierter Schwefelsäure bei Raumtemperatur.  Dann wird der Rückstand gepulvert und  nochmals scharf getrocknet.  



  Das Präparat enthält somit annähernd  gleiche Gewichtsteile Säure und     Coffein.     Es ist in Wasser leicht löslich.



  Process for the production of a new preparation containing caffeine. The main patent describes a process for the production of a new caffeine-containing preparation, according to which an ß-naphthyl fatty acid is neutralized with sodium hydroxide solution until the solution has a p11 value of 8.5, and then caffeine is added to the solution in an amount by weight that is little approximately equal to the weight of the acid used, whereupon the solution is adjusted to the neutral point by further addition of ss-naphthyl fatty acid and evaporated to dryness.



  It has now been found that one arrives at a therapeutically equivalent caffeine-containing preparation if one uses an β-inclolyl fatty acid, e.g. B. ss-indolylacetic acid, ss - indolylpropionic acid. ss - indolylvaleric acid, ss-indolylbutyric acid, neutralized with sodium hydroxide solution until the solution has a pH value of 8.5, caffeine is added to the solution in an amount by weight,

   which is at least approximately equal to the weight of the acid used, and then, by adding further ss-indolyl fatty acid, the solution is precisely set to the neutral point and evaporated to dryness. <I> Example: </I> 30 g of ß-indolylacetic acid recrystallized twice from benzene are dissolved in the calculated amount in sodium hydroxide solution.

   The solution obtained is still strongly alkaline and a further 3-4 g of β-indolylacetic acid are added, a pH of 8.5 being reached. Then 33-34 g of caffeine are added to the solution, which hardly changes the pH. By adding about 1/2 g of ss-indolylacetic acid, the pH of the solution is brought to exactly the neutral point.

    The solution is then evaporated to dryness in a vacuum desiccator over concentrated sulfuric acid at room temperature. Then the residue is powdered and dried again sharply.



  The preparation thus contains approximately equal parts by weight of acid and caffeine. It is easily soluble in water.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines neuen eoffeinhaltigen Präparates, dadurch gekenn zeichnet, dass man eine ss-Indolylfettsäure mit Natronlauge neutralisiert, bis die Lösung einen pH-Wert von 8,5 aufweist, der Lösung dann Coffein in einer Gewichtsmenge zu setzt, die wenigstens annähernd gleich ist der Mengo der angewendeten Säure, und darauf durch weiteren Zusatz von ss-Indolylfett- säure die Lösung genau auf den Neutral punkt einstellt und zur Trockne verdampft. PATENT CLAIM: Process for the production of a new eaffeine-containing preparation, characterized in that an ß-indolyl fatty acid is neutralized with sodium hydroxide solution until the solution has a pH value of 8.5, then caffeine is added to the solution in an amount by weight that is at least approximately The amount of acid used is the same, and then by adding further ss-indolyl fatty acid the solution is precisely set to the neutral point and evaporated to dryness. Das erhaltene Produkt ist in Wasser leicht löslich und die Lösung reagiert neutral. Es ist für therapeutische Zwecke bestimmt. The product obtained is easily soluble in water and the solution has a neutral reaction. It is intended for therapeutic use.
CH247163D 1942-09-15 1942-09-15 Process for the production of a new preparation containing caffeine. CH247163A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH247163T 1942-09-15
CH242051T 1942-09-15

Publications (1)

Publication Number Publication Date
CH247163A true CH247163A (en) 1947-02-15

Family

ID=25728635

Family Applications (1)

Application Number Title Priority Date Filing Date
CH247163D CH247163A (en) 1942-09-15 1942-09-15 Process for the production of a new preparation containing caffeine.

Country Status (1)

Country Link
CH (1) CH247163A (en)

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