CH247164A - Process for the production of a new preparation containing caffeine. - Google Patents

Process for the production of a new preparation containing caffeine.

Info

Publication number
CH247164A
CH247164A CH247164DA CH247164A CH 247164 A CH247164 A CH 247164A CH 247164D A CH247164D A CH 247164DA CH 247164 A CH247164 A CH 247164A
Authority
CH
Switzerland
Prior art keywords
solution
caffeine
acid
production
weight
Prior art date
Application number
Other languages
German (de)
Inventor
Adrien Dr Med Schoch
Original Assignee
Adrien Dr Med Schoch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adrien Dr Med Schoch filed Critical Adrien Dr Med Schoch
Publication of CH247164A publication Critical patent/CH247164A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/12—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1, 3, and 7, e.g. caffeine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur     Bierstellung        eines    neuen     coffeinhaltigen    Präparates.         Im.        Hauptpatent    ist ein Verfahren zur  Herstellung eines neuen     coffeinhaltigen    Prä  parates beschrieben, gemäss welchem man  eine     ss-hTaphthylfettsäure        mit    Natronlauge  neutralisiert, bis die Lösung einen     p11-Wert     von 8,5 aufweist, der     Lösung    dann     Coffein     in einer     Gewichtsmenge    zusetzt, die wenig  stens annähernd gleich ist dem Gewicht der  angewendeten Säure,

   worauf man durch wei  teren Zusatz von     ss-Naphthylfettsäure    die  Lösung genau auf den     Neutralpunkt    einstellt  und zur Trockne verdampft.  



  Es wurde     nun    gefunden, dass man zu  einem therapeutisch gleichwertigen     coffein-          haltigen    Präparat gelangt, wenn man eine       ss-Pyrrylfettsäure,    z. B.     ss-Pyrrylessigsäure,          ss-Pyrrylpropionsäure,        ss-Pyrrylvaleriansäure,          ss-Pyrrylbuttersäure,        mit    Natronlauge neu  tralisiert, bis die Lösung einen PH-Wert von  8,5 aufweist, der Lösung     Coffein    in einer       Gewichtsmenge    zusetzt,

   die wenigstens an  nähernd gleich dem Gewicht der angewen  deten Säure ist und darauf durch weiteren       Zusatz    von     ss-Pyrrylfettsäure    die Lösung  genau auf den     Neutralpunkt    einstellt und  zur Trockne verdampft.  



  <I>Beispiel:</I>  30 g zweimal aus Benzol umkristallisier  ter     ss-Pyrrylessigsäure    werden in der berech  neten Menge In Natronlauge gelöst. Die er  haltene Lösung ist noch stark alkalisch und  wird mit weiteren 3 g     Pyrrylessigsäure    ver  setzt,     wobei    ein     pH-Wert    von 8,5 erreicht    wird. Dann werden der Lösung 33 g     Coffein     zugesetzt, wodurch sich der     pH-Wert    kaum  ändert. Durch Zugabe von zirka     i/2    g       ss-Pyrrylessigsäure    wird der     pH-Wert    der Lö  sung an den     Neutralpunkt    gebracht.

   Dann  erfolgt Eindampfen der.     Lösung    zur Trockne  im     Vakuumexsikkator    über konzentrierter  Schwefelsäure bei     Raumtemperatur.        Dei          Riiekstand        wird    dann gepulvert und noch  mals scharf     getrocknet.     



  Das Präparat enthält somit annähernd  gleiche Gewichtsteile Säure und     Coffein.    Es  ist leicht in Wasser löslich und diese Lösung  reagiert völlig neutral. Es ist zu therapeu  tischer Verwendung     bestimmt.  



  Process for making beer from a new preparation containing caffeine. The main patent describes a process for the production of a new caffeine-containing preparation, according to which an ß-h-taphthyl fatty acid is neutralized with sodium hydroxide solution until the solution has a p11 value of 8.5, and then caffeine is added to the solution in an amount by weight that is low is at least approximately equal to the weight of the acid used,

   whereupon one adjusts the solution exactly to the neutral point by further addition of ss-naphthyl fatty acid and evaporates to dryness.



  It has now been found that a therapeutically equivalent caffeine-containing preparation is obtained if an β-pyrryl fatty acid, e.g. B. ß-pyrryl acetic acid, ß-pyrrylpropionic acid, ß-pyrrylvaleric acid, ß-pyrrylbutyric acid, neutralized with sodium hydroxide solution until the solution has a pH value of 8.5, caffeine is added to the solution in an amount by weight,

   which is at least approximately equal to the weight of the acid used and then, by adding further ss-pyrryl fatty acid, sets the solution exactly to the neutral point and evaporates to dryness.



  <I> Example: </I> 30 g of ß-pyrrylacetic acid recrystallized twice from benzene are dissolved in the calculated amount in sodium hydroxide solution. The he obtained solution is still strongly alkaline and is ver with a further 3 g of pyrylacetic acid, a pH of 8.5 is reached. Then 33 g of caffeine are added to the solution, which hardly changes the pH. The pH of the solution is brought to the neutral point by adding about 1/2 g of s-pyrrylacetic acid.

   Then the evaporation takes place. Solution to dryness in a vacuum desiccator over concentrated sulfuric acid at room temperature. The Riiekstand is then powdered and dried again sharply.



  The preparation thus contains approximately equal parts by weight of acid and caffeine. It is easily soluble in water and this solution is completely neutral. It is intended for therapeutic use.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines neuen coffeinhaltigen Präparates, dadurch gekenn zeichnet, dass man eine ss-Pyrrylfettsäure mit Natronlauge neutralisiert, bis die Lösung einen pH-Wert von 8,5 aufweist, der Lösung dann Coffein in einer Gewichtsmenge zusetzt, die wenigstens annähernd gleich ist dem Ge wicht der angewendeten Säure, und darauf durch weiteren Zusatz von ss-Pyrrylfettsäure die Lösung genau auf den Neutralpunkt ein stellt und zur Trockne verdampft. PATENT CLAIM: Process for the production of a new caffeine-containing preparation, characterized in that an β-pyrryl fatty acid is neutralized with sodium hydroxide solution until the solution has a pH value of 8.5, then caffeine is added to the solution in an amount by weight that is at least approximately the same is the weight of the acid used, and then by adding further ss-pyrryl fatty acid, the solution sets exactly to the neutral point and evaporates to dryness. Das er haltene Produkt ist in Wasser leicht löslich und die Lösung reagiert neutral. Es ist für therapeutische Zwecke bestimmt. The product obtained is easily soluble in water and the solution is neutral. It is intended for therapeutic use.
CH247164D 1942-09-15 1942-09-15 Process for the production of a new preparation containing caffeine. CH247164A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH242051T 1942-09-15
CH247164T 1942-09-15

Publications (1)

Publication Number Publication Date
CH247164A true CH247164A (en) 1947-02-15

Family

ID=25728636

Family Applications (1)

Application Number Title Priority Date Filing Date
CH247164D CH247164A (en) 1942-09-15 1942-09-15 Process for the production of a new preparation containing caffeine.

Country Status (1)

Country Link
CH (1) CH247164A (en)

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