CH200934A - Process for the preparation of a compound of theobromine. - Google Patents

Process for the preparation of a compound of theobromine.

Info

Publication number
CH200934A
CH200934A CH200934DA CH200934A CH 200934 A CH200934 A CH 200934A CH 200934D A CH200934D A CH 200934DA CH 200934 A CH200934 A CH 200934A
Authority
CH
Switzerland
Prior art keywords
theobromine
lithium
reacted
compound
isovaleric acid
Prior art date
Application number
Other languages
German (de)
Inventor
Ignaz Grossberg
Original Assignee
Ignaz Grossberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ignaz Grossberg filed Critical Ignaz Grossberg
Publication of CH200934A publication Critical patent/CH200934A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Herstellung einer Verbindung des     Theobromins.       Gegenstand des Hauptpatentes ist ein Ver  fahren zur Herstellung einer Verbindung von       Theobromin    mit einer organischen Säure, wo  bei     Theobromin    mit     Natriumhydroxyd    zu       Theobrominnatrium    umgesetzt und dieses mit  dem     Natriumsalz    der     Isovaleriansäure    zur Re  aktion gebracht wird.  



  Gegenstand des vorliegenden Patentes ist  ein Verfahren zur Herstellung einer weiteren  therapeutisch wertvollen Doppelverbindung aus       Theobromin.    Das Verfahren ist dadurch ge  kennzeichnet, dass     Theobromin    mit     Lithium-          hydroxyd    zu     Theobrominlithium    umgesetzt  und dieses mit dem     Lithiumsalz    der     Iso-          valeriansäure    zur Reaktion gebracht wird, wo  bei eine farblose, leicht wasserlösliche Ver  bindung entsteht.

   Die neue Verbindung hat  neben blutdrucksenkender und     diurethischer     Wirkung auch ausgezeichnete sedative und  krampflösende Wirkung, ohne die unerwünsch  ten Begleiterscheinungen bekannter Präparate  zu zeigen. Sie eignet sich vorzüglich zu Dauer  behandlungen, zum Beispiel bei Arterioskle-         rose,        klimakterischen    Beschwerden und Be  schwerden, hervorgerufen durch. hohen Blut  druck.  



  Die Umsetzung der Reaktionskomponen  ten erfolgt vorteilhaft in wässerigem oder  alkalisch wässerigem Medium, derart, dass  man molekulare Mengen des     Theobromin-          lithiums    und des     Lithiumsalzes    der     Isovale-          riansäure    in einem Lösungsmittel zur Um  setzung bringt und das Reaktionsgemisch  zweckmässig zur Trockene einengt.    <I>Beispiel:</I>    11,97 Teile     Lithiumhydrogyd    löst man in  200 Teilen destilliertem Wasser und setzt  hierauf eine konzentrierte Lösung von 51 Teilen       Isovaleriansäure    zu.

   Zu dieser Lösung wird  eine alkoholische Lösung, hergestellt aus 99  Teilen     Theobromin    und 11,97 Teilen     Lithium-          hydroxyd,    zugesetzt und hierauf wird das  Reaktionsgemisch auf dem Wasserbade, zweck  mässig unter vermindertem Druck, bis zur  Trockene eingedampft.     Es    verbleibt ein weisses,      kristallines, leicht wasserlösliches Produkt,  welches rote Flammenfärbung und     Murezid-          reaktion    gibt.



  Process for the preparation of a compound of theobromine. The main patent is a process for the production of a compound of theobromine with an organic acid, where theobromine is reacted with sodium hydroxide to form theobromine sodium and this is brought to the reaction with the sodium salt of isovaleric acid.



  The subject of the present patent is a process for the preparation of a further therapeutically valuable double compound from theobromine. The process is characterized in that theobromine is reacted with lithium hydroxide to form theobromine lithium and this is made to react with the lithium salt of isovaleric acid, producing a colorless, easily water-soluble compound.

   The new compound has an antihypertensive and diuretic effect as well as an excellent sedative and antispasmodic effect without showing the undesirable side effects of known preparations. It is particularly suitable for long-term treatments, for example for arteriosclerosis, climacteric complaints and complaints caused by. high blood pressure.



  The reaction components are advantageously reacted in an aqueous or alkaline aqueous medium in such a way that molecular amounts of theobromonithium and the lithium salt of isovaleric acid are reacted in a solvent and the reaction mixture is expediently concentrated to dryness. <I> Example: </I> 11.97 parts of lithium hydrogen are dissolved in 200 parts of distilled water and a concentrated solution of 51 parts of isovaleric acid is then added.

   An alcoholic solution, prepared from 99 parts of theobromine and 11.97 parts of lithium hydroxide, is added to this solution, and the reaction mixture is then evaporated to dryness on a water bath, advantageously under reduced pressure. A white, crystalline, easily water-soluble product remains, which gives a red flame color and a mureocide reaction.

Claims (1)

<B>PATENTANSPRUCH:</B> Verfahren zur Herstellung einer Verbin dung von Theobromin mit einer organiacben Säure, dadurch gekennzeichnet, dass Theo bromin mit Lithiumhydrosyd zu Theobromin- lithium umgesetzt und dieses mit dem Li- thiumsalz der Isovaleriansäure zur Reaktion gebracht wird. <B> PATENT CLAIM: </B> Process for the production of a compound of theobromine with an organiacbene acid, characterized in that theobromine is reacted with lithium hydroside to form theobromine lithium and this is reacted with the lithium salt of isovaleric acid. Das Endprodukt dieses Ver fahrens, eine farblose, leicht wasserlöaliohe, kristalline Verbindung, ist neu; es soll als Mittel bei der Behandlung von Arterieakle- rose, klimakterisehen Beschwerden und der gleichen verwendet werden, und besitzt nebst einer blutdrucksenkenden und diurethiachen auch eine krampflösende und ausgezeichnete sedative Wirkung. UNTERANSPRTJCHE 1. The end product of this process, a colorless, slightly water-soluble, crystalline compound, is new; it is intended to be used as an agent in the treatment of arterial aclerosis, climacteric complaints and the like, and besides reducing blood pressure and diuretics it also has an antispasmodic and excellent sedative effect. SUBClaims 1. Verfahren nach Patentanapruch, dadurch gekennzeichnet,<B>dass</B> man molekulare Men gen des Lithiumsalses der 1sovaleriansäure und des Tbeobrominlithiums in einem Lö sungsmittel zur Umsetzung bringt und das Reaktionsgemisch :nur Trockene einengt. 2. Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man Wasser als Lö sungsmittel verwendet. 3. A method according to patent claim, characterized in that molecular quantities of lithium salts, isovaleric acid and tbeobromine lithium are reacted in a solvent and the reaction mixture is concentrated only in the dry state. 2. The method according to claim, characterized in that water is used as a solvent. 3. Verfahren nach Patentanspruch und Unter anspruch 1, dadurch gekennzeichnet, dass das Einengen bei vermindertem Druck erfolgt. Method according to claim and sub-claim 1, characterized in that the concentration takes place at reduced pressure.
CH200934D 1936-03-30 1936-11-11 Process for the preparation of a compound of theobromine. CH200934A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT200934X 1936-03-30
CH194883T 1936-11-11

Publications (1)

Publication Number Publication Date
CH200934A true CH200934A (en) 1938-10-31

Family

ID=25607693

Family Applications (1)

Application Number Title Priority Date Filing Date
CH200934D CH200934A (en) 1936-03-30 1936-11-11 Process for the preparation of a compound of theobromine.

Country Status (1)

Country Link
CH (1) CH200934A (en)

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