CH178944A - Process for the preparation of 2-oxydiphenyl ether-5-carboxylic acid. - Google Patents

Process for the preparation of 2-oxydiphenyl ether-5-carboxylic acid.

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Publication number
CH178944A
CH178944A CH178944DA CH178944A CH 178944 A CH178944 A CH 178944A CH 178944D A CH178944D A CH 178944DA CH 178944 A CH178944 A CH 178944A
Authority
CH
Switzerland
Prior art keywords
carboxylic acid
ether
oxydiphenyl
preparation
oxydiphenyl ether
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellschaft Chem Heyden
Original Assignee
Heyden Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heyden Chem Fab filed Critical Heyden Chem Fab
Publication of CH178944A publication Critical patent/CH178944A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Darstellung von     2-Ogydiphenyläther-5-earbonsäur    e.    Im Patent Nr. 173976 ist die Darstellung  der     2-Oxydiphenyliither-3-carbonsäure    durch  Behandeln des     Nntriunisalzes    des     2-Oxydi-          phenyläthers    mit Kohlensäure unter erhöhtem  Druck und bei erhöhter Temperatur be  schrieben.  



  Es wurde nun gefunden, dass man     2-Oxy-          diphenyläther-5-carbonsäure    erhält; wenn man  das     Kaliumsalz    des     2-Oxydiphenyläthers    mit  Kohlensäure unter erhöhtem Druck und bei  erhöhter     Temporatur    behandelt. Auch dieser  neue Stoff findet entweder als     soleher    z. B.  in Form der Salze und Ester oder als Zwi  schenprodukt für pharmazeutische oder tech  nische Zwecke Verwendung.

      <I>Beispiel:</I>  252     gr        2-Oxydiphenyläther    werden in einer  wässerigen Lösung vor) 76     gr        Kaliumhydroxyd     gelöst; diese Lösung wird unter Rühren  schliesslich im Vakuum zur Trockene gebracht  und das trockene Pulver bei 220-230' mit    Kohlensäure von 20     Atm.    20-24 Stunden  lang behandelt.

   Aus der filtrierten, wässerigen  Lösung erhält man nach geeigneter     Abschei-          dung    von nicht umgesetztem     2-Oxydiphenyl-          äther    durch Ansäuern die     2-Oxydiphenyläther-          5-carbonsäure    neben etwas     2-Oxydiphenyl-          äther-3-carbonsäure.    Die Trennung erfolgt auf       Irund    der leichteren Löslichkeit des     Calcium-          salzes    der     2-Oxydiphenyläther-5-carbonsäure     in Wasser.

   Die     2-Oxydiphenyläther-5-cai@bon-          säure    wird aus der wässerigen Lösung ihres       Calziumsalzes    durch Ansäuern gewonnen. Sie  bildet aus Benzol oder aus verdünntem Alkohol  umkristallisiert farblose     Nädelchen    vom F.       152/54 ,    die in Wasser schwer löslich sind.



  Process for the preparation of 2-Ogydiphenyläther-5-carbonsäur e. Patent No. 173976 describes the preparation of 2-oxydiphenyliither-3-carboxylic acid by treating the Nntriunisalzes of 2-Oxydiphenyläthers with carbonic acid under elevated pressure and at elevated temperature be.



  It has now been found that 2-oxydiphenyl ether-5-carboxylic acid is obtained; if the potassium salt of 2-oxydiphenyl ether is treated with carbonic acid under increased pressure and at increased temp. This new substance is also found either as soleher z. B. in the form of salts and esters or as an inter mediate product for pharmaceutical or tech nical purposes use.

      <I> Example: </I> 252 grams of 2-oxydiphenyl ether are dissolved in an aqueous solution in front of) 76 grams of potassium hydroxide; this solution is finally brought to dryness in vacuo with stirring and the dry powder at 220-230 'with carbonic acid of 20 atm. Treated for 20-24 hours.

   From the filtered, aqueous solution, after suitable separation of unreacted 2-oxydiphenyl ether by acidification, the 2-oxydiphenyl ether-5-carboxylic acid and some 2-oxydiphenyl ether-3-carboxylic acid are obtained. The separation takes place on account of the easier solubility of the calcium salt of 2-oxydiphenyl ether-5-carboxylic acid in water.

   The 2-oxydiphenyl ether-5-cai @ bon- acid is obtained from the aqueous solution of its calcium salt by acidification. It forms colorless needles of F. 152/54 recrystallized from benzene or from dilute alcohol, which are sparingly soluble in water.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung von 2-Oxydi- phenyläther-5-carbonsäure, dadurch gekenn zeichnet, dass man das Kaliumsalz des 2 Oxydipber)ylätliers mit Kohlensäure unterer höhtem Druck und bei erhöhter Temperatur behandelt. Die erhaltene 2-Oxydiphenyläther-5-carbon- säure bildet farblose Nadeln vorn F. 152l54 , die in Wasser schwer löslich sind. PATENT CLAIM: A process for the preparation of 2-oxydiphenyl ether-5-carboxylic acid, characterized in that the potassium salt of the 2 oxydipber) yl ether is treated with carbonic acid under elevated pressure and at elevated temperature. The 2-oxydiphenyl ether-5-carboxylic acid obtained forms colorless needles of F. 152,154 which are sparingly soluble in water. UNTERANSPRUCH: Verfahren nach Patentanspruch, dadurch gekennzeichnet, da15 man die 2-Oxydiphenyl- äther-5-carbonsäure auf Grund ihrer Löslich keit und der Löslichkeit ihrer Salze von gleichzeitig gebildeter 2-Oxydiphenyläther-3- carbonsäure trennt. SUBSTANTIAL CLAIM: Process according to patent claim, characterized in that the 2-oxydiphenyl ether-5-carboxylic acid is separated from the 2-oxydiphenyl ether-3-carboxylic acid formed at the same time on the basis of its solubility and the solubility of its salts.
CH178944D 1934-06-15 1934-06-15 Process for the preparation of 2-oxydiphenyl ether-5-carboxylic acid. CH178944A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH178944T 1934-06-15
CH167171T 1934-06-15

Publications (1)

Publication Number Publication Date
CH178944A true CH178944A (en) 1935-08-15

Family

ID=25718386

Family Applications (1)

Application Number Title Priority Date Filing Date
CH178944D CH178944A (en) 1934-06-15 1934-06-15 Process for the preparation of 2-oxydiphenyl ether-5-carboxylic acid.

Country Status (1)

Country Link
CH (1) CH178944A (en)

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