CH173976A - Process for the preparation of 2-oxydiphenyl ether-3-carboxylic acid. - Google Patents

Process for the preparation of 2-oxydiphenyl ether-3-carboxylic acid.

Info

Publication number
CH173976A
CH173976A CH173976DA CH173976A CH 173976 A CH173976 A CH 173976A CH 173976D A CH173976D A CH 173976DA CH 173976 A CH173976 A CH 173976A
Authority
CH
Switzerland
Prior art keywords
carboxylic acid
preparation
oxydiphenyl
ether
oxydiphenyl ether
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellschaft Chem Heyden
Original Assignee
Heyden Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heyden Chem Fab filed Critical Heyden Chem Fab
Publication of CH173976A publication Critical patent/CH173976A/en

Links

Description

  

  Verfahren zur Darstellung von     2-Ogydiphenyläther-3-karbonsäure.       Im Hauptpatent ist die Herstellung von       4-Oxydiphenyläther-3-karbonsäure    durch Be  handeln eines     Alkalisalzes    des     4-Oxydiphenyl-          äthers    mit Kohlensäure unter erhöhtem Druck  und bei erhöhten Temperaturen     beschrieben.     



  Es wurde nun gefunden, dass man durch  Behandeln des     Natriumsalzes    des     2-Oydi-          phenyläthers    mit Kohlensäure unter erhöh  tem Druck die     2-Oxydiphenyläther-3-karbon-          säure    erhält. Auch dieser neue Stoff findet  entweder als solcher zum Beispiel in Form  der Salze und Ester oder als Zwischenpro  dukt für pharmazeutische oder technische  Zwecke Verwendung.  



       Beispiel:     185     gr        o-Oxydiphenyläther    werden in  einer wässerigen Lösung von 40     gr    Natrium  hydroxyd gelöst, die Lösung wird unter     Il.üh-          ren    schliesslich im Vakuum zur Trockne ge  bracht und das trockene Pulver bei 160<B>0</B>    mit Kohlensäure von 20     Atm.    10-12 Stun  den behandelt. Aus der filtrierten wässerigen  Lösung erhält man durch     Ansäuren    die 2  Oxydiphenyläther-S-karbonsäure. Sie bildet  aus Benzol oder verdünntem Alkohol um  kristallisiert farblose Nadeln vom F. P. 142  ,  die in Wasser schwer löslich sind. Die wäs  serige Lösung gibt mit Eisenchlorid Violett  färbung.  



  Neben der     2-Oxydiphenyläther-3-karbon-          säure    bilden sich geringe Mengen der     2-Oxydi-          phenyläther-5-karbonsäure.     



  Man kann die beiden Säuren trennen  und die     2-Oxydiphenyläther-3-karbonsäure,     deren     Calciumsalz    schwer löslich ist, in rei  ner Form     zewinnen.  



  Process for the preparation of 2-Ogydiphenyläther-3-carboxylic acid. The main patent describes the production of 4-oxydiphenyl ether-3-carboxylic acid by treating an alkali salt of 4-oxydiphenyl ether with carbonic acid under increased pressure and at increased temperatures.



  It has now been found that treating the sodium salt of 2-oxydiphenyl ether with carbonic acid under increased pressure gives 2-oxydiphenyl ether-3-carbonic acid. This new substance is also used either as such, for example in the form of salts and esters, or as an intermediate product for pharmaceutical or technical purposes.



       Example: 185 grams of o-oxydiphenyl ether are dissolved in an aqueous solution of 40 grams of sodium hydroxide, the solution is finally brought to dryness in a vacuum while stirring and the dry powder is added to it at 160 Carbonic acid of 20 atm. Treated for 10-12 hours. The 2 oxydiphenyl ether-S-carboxylic acid is obtained from the filtered aqueous solution by acidification. From benzene or dilute alcohol it forms colorless needles of F. P. 142 which are sparingly soluble in water. The aqueous solution turns violet with ferric chloride.



  In addition to the 2-oxydiphenyl ether-3-carbonic acid, small amounts of the 2-oxydiphenyl ether-5-carboxylic acid are formed.



  The two acids can be separated and the 2-oxydiphenyl ether-3-carboxylic acid, the calcium salt of which is sparingly soluble, can be obtained in pure form.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung von 2-Oxydi- phenyläther-3-karbonsäure, dadurch gekenn- zeichnet, dass man das Natriumsalz von 2 Ogydiphenyläther mit Kohlensäure unter er höhtem Druck und bei erhöhten Tempera turen behandelt. Das erhaltene Produkt bildet farblose Nadeln vom F. P. 142<B>0</B> , die in Wasser schwer löslich sind. Die wässerige Lösung gibt mit Eisenchlorid Violettfärbung. PATENT CLAIM: Process for the preparation of 2-oxydiphenyl ether-3-carboxylic acid, characterized in that the sodium salt of 2-oxydiphenyl ether is treated with carbonic acid under increased pressure and at increased temperatures. The product obtained forms colorless needles of F. P. 142 <B> 0 </B>, which are sparingly soluble in water. The aqueous solution turns violet with ferric chloride.
CH173976D 1932-05-13 1933-01-17 Process for the preparation of 2-oxydiphenyl ether-3-carboxylic acid. CH173976A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE173976X 1932-05-13
CH167171T 1934-06-15

Publications (1)

Publication Number Publication Date
CH173976A true CH173976A (en) 1934-12-15

Family

ID=25718388

Family Applications (1)

Application Number Title Priority Date Filing Date
CH173976D CH173976A (en) 1932-05-13 1933-01-17 Process for the preparation of 2-oxydiphenyl ether-3-carboxylic acid.

Country Status (1)

Country Link
CH (1) CH173976A (en)

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