CH192303A - Process for the preparation of 1-cyclohexyl-2,3-dimethyl-4-methylamino-5-pyrazolone-4-methanesulfonic acid quinine. - Google Patents

Process for the preparation of 1-cyclohexyl-2,3-dimethyl-4-methylamino-5-pyrazolone-4-methanesulfonic acid quinine.

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Publication number
CH192303A
CH192303A CH192303DA CH192303A CH 192303 A CH192303 A CH 192303A CH 192303D A CH192303D A CH 192303DA CH 192303 A CH192303 A CH 192303A
Authority
CH
Switzerland
Prior art keywords
dimethyl
pyrazolone
cyclohexyl
methylamino
methanesulfonic acid
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH192303A publication Critical patent/CH192303A/en

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Description

  

  Verfahren zur Herstellung von     1-eyclohegyl-2,3-dimethyl-4-methylamino-5-pyrazolon-          4-methansulfonsaurem    Chinin.    Im Hauptpatent ist ein Verfahren zur  Herstellung von     1-pherryl-2,3-dimetbyl-4-me-          thylamirro-5-pyrazolon-4-methansulforrsaurem     Chinin beschrieben, welches dadurch gekenn  zeichnet ist, dass man 1-Phenyl-2,3-dimethyl       4-methylamino-5-pyrazolon-4-methansulforr-          säure    mit     Chininbase    zur Umsetzung bringt.  



  Es wurde gefunden, dass man     1-cyclo-          h        exyl    - 2,3 -     dimethyl    - 4-     methylamino    - 5 -     pyr-          azolon-4-methansulforrsaures    Chinin erhält,  wenn man     1-Cyclohexyl-2,3-dimethyl-4-me-          thylamino    - 5 -     pyrazolon    - 4-     methansulfonsäure     mit     Chininbase    zur Umsetzung bringt. Dabei  kann man z.

   B.     1-Cyclohexyl-2,3-dimethyl-4-          methylamino-5-pyrazolon.4-methansulfonsäur-e     verwenden, die durch Einwirkenlassen von  Formaldehyd und schweflige Säure auf     1-          Cyclohexyl-2,        3-dimethyl-4-m        ethyl        ainin        o.5-pyr-          azolon    in Gegenwart der     Chininbase    erhalten  wurde.    Die neue Verbindung bildet farblose, in  Wasser leicht, in     Methyl-    und Äthylalkohol  schwerer, und in Aceton und Äther fast un  lösliche Kristalle.

   Sie stellt ein wertvolles  Arzneimittel dar, welches die Wirkung der  einzelnen Ausgangsstoffe     übertrifft.    Sie kann  gegebenenfalls mit einzelnen     Arzneistoffen     gemischt werden und soll in der Therapie  Verwendung finden.    <I>Beispiel:</I>    7,4 g     Chininbase    und 6,6 g     1-Cyclohexyl-          2,3    -     dimetbyl    - 4 -     methylamino-    5     -pyrazolon-4-          methansulfonsäure    (dargestellt nach dem  Schweizer Patent Nr. 184875) werden in  40 cm' Aceton gelöst und mit Äther bis zur  beginnenden Trübung versetzt.

   Beim Ab  kühlen kristallisiert das gebildete     Chininsalz     aus, das mit Äther nachgewaschen wird.  Schmelzpunkt<B>151-1530</B> C. Das Salz ist in  Wasser löslich.



  Process for the preparation of 1-eyclohegyl-2,3-dimethyl-4-methylamino-5-pyrazolone-4-methanesulfonic acid quinine. The main patent describes a process for the preparation of 1-pherryl-2,3-dimetbyl-4-methylamirro-5-pyrazolone-4-methanesulforrsaurem quinine, which is characterized in that 1-phenyl-2,3- dimethyl 4-methylamino-5-pyrazolone-4-methanesulforric acid with quinine base for implementation.



  It has been found that 1-cyclohexyl-2,3-dimethyl-4-methylamino-5-pyrazolone-4-methanesulfuric quinine is obtained when 1-cyclohexyl-2,3-dimethyl-4-me is obtained - brings thylamino - 5 - pyrazolon - 4 - methanesulfonic acid with quinine base to implement. You can z.

   B. 1-Cyclohexyl-2,3-dimethyl-4-methylamino-5-pyrazolon.4-methanesulfonic acid-e use which by the action of formaldehyde and sulphurous acid on 1- cyclohexyl-2,3-dimethyl-4-m ethyl ainine o.5-pyrazolone was obtained in the presence of the quinine base. The new compound forms colorless crystals, easily soluble in water, more difficult in methyl and ethyl alcohol, and almost insoluble in acetone and ether.

   It is a valuable medicine that exceeds the effects of the individual raw materials. If necessary, it can be mixed with individual drugs and should be used in therapy. <I> Example: </I> 7.4 g quinine base and 6.6 g 1-cyclohexyl- 2,3 - dimetbyl - 4 - methylamino- 5-pyrazolone-4-methanesulphonic acid (shown according to Swiss patent no. 184875) are dissolved in 40 cm 'acetone and mixed with ether until the onset of turbidity.

   When cooling down, the quinine salt formed crystallizes out, which is washed with ether. Melting point <B> 151-1530 </B> C. The salt is soluble in water.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von 1-cyclo- hexyl - 2,3 - dimethyl - 4 - methylamino - ö - pyr- azolon-4-methansulfonsaurem Cinin, dadurch gekennzeichnet, dass man 1-Cycloxyl-2,3-di methyl-4-methyllmino-5-pyrazolon-4-methan- sulfonsäure mit Chininbase zur Umsetzucig bringt. Claim: Process for the preparation of 1-cyclohexyl-2,3-dimethyl-4-methylamino-ö -pyr-azolon-4-methanesulfonic acid cinin, characterized in that 1-cycloxyl-2,3-dimethyl-4 -methyllmino-5-pyrazolone-4-methanesulphonic acid with quinine base for Umsetzucig. Die neue Verbindung bildet farblose, in Wasser leicht, in 1Methyl- und .Äthylalkohol schwerer, und in Aceton und Äther fast un lösliche Kristalle. Sie soll als Heilmittel Verwendung finden. UNTERANSPRUCH: Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man 1-Cyclohexyl-2,3- dimethyl - 4 - inethylamino - 5 - pyrazolon-4-me- thansulfonsäure verwendet, die erhalten wurde durch Einwirkenlassen von Formaldehyd und schwefliger Säure auf 1-Cyclohexyl-2, The new compound forms colorless crystals, easily soluble in water, more difficult in methyl and ethyl alcohol, and almost insoluble in acetone and ether. It is said to be used as a remedy. SUBSTITUTE SHEET: Process according to claim, characterized in that 1-cyclohexyl-2,3-dimethyl-4-ynethylamino-5-pyrazolone-4-methanesulfonic acid is used, which was obtained by allowing formaldehyde and sulfurous acid to act on 1-cyclohexyl -2, 3-di- methyl-4-methylamino-5-pyrazolon in Gegen wart der Chininbase. 3-dimethyl-4-methylamino-5-pyrazolone in the presence of the quinine base.
CH192303D 1934-03-03 1935-02-25 Process for the preparation of 1-cyclohexyl-2,3-dimethyl-4-methylamino-5-pyrazolone-4-methanesulfonic acid quinine. CH192303A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE192303X 1934-03-03
CH186957T 1935-02-25

Publications (1)

Publication Number Publication Date
CH192303A true CH192303A (en) 1937-07-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CH192303D CH192303A (en) 1934-03-03 1935-02-25 Process for the preparation of 1-cyclohexyl-2,3-dimethyl-4-methylamino-5-pyrazolone-4-methanesulfonic acid quinine.

Country Status (1)

Country Link
CH (1) CH192303A (en)

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