CH192068A - Process for the preparation of a 3- (dioxypropyl-oxyethyl) -amino-4-oxy-3'-amino-4'-oxyarsenobenzene sulfoxylate. - Google Patents

Process for the preparation of a 3- (dioxypropyl-oxyethyl) -amino-4-oxy-3'-amino-4'-oxyarsenobenzene sulfoxylate.

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Publication number
CH192068A
CH192068A CH192068DA CH192068A CH 192068 A CH192068 A CH 192068A CH 192068D A CH192068D A CH 192068DA CH 192068 A CH192068 A CH 192068A
Authority
CH
Switzerland
Prior art keywords
amino
sulfoxylate
dioxypropyl
oxyethyl
preparation
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH192068A publication Critical patent/CH192068A/en

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Description

  

  Verfahren zur Herstellung eines     3-(Diogypropyl-ogyäthyl)-amino-4-ogy-3'-amino-4'-          ozyarsenobenzolsulfogylats.       Das     Hauptpatent    betrifft ein Verfahren  zur     Herstellung    von 3-(Bis--dioxypropyl)       amino-4,4'-@dioxyarsenobenzol-,3'-aminomono-          forma1,dehyd@sulfoxylatnatrium,    welches da  durch gekennzeichnet ist,     @dass    man     Glycid     mit     einer        Lösung    von 3;

  3' -     Diamino    - 4,4'  dioxyarsenobenzolmonof     ormaldehyd-sulf        oxy-          latnatrium    zur     Umsetzung    bringt.  



  Es wurde nun gefunden,     dass,    man zu  einer     Verbindung    von gleich wertvollen phar  makologischen     -Eigenschaften    auch gelangen  kann,     wenn    man eine     Lösung    von     3,3'-Di-          amino    - 4,4' -     dioxyarsenobenzolmonoformal        -          dehydsulfoxylatnatrium,        Glycid        und        Ithy-          lenoxyd    aufeinander     einwirken    lässt.

   Das auf  diese Weise erhältliche 3 -     (Dioxypropy        1-          oxyäthyl)    -     amino-4,4'    -     dioxyarsenobenzol-        3'-          aminoformaldehyd,sulfoxylatnatrium    bildet         ein    in Wasser leicht     lösliches,    in Äther und       Athylalkohol        unlösliches        gelbes    Pulver: Es  soll als     Heilmittel        Verwendung    finden.  



  <I>Beispiel:</I>  77,5 g     3"3'-Diamino-4,4'-dioxyarsenoben-          zolmonoforma1,delhydsulfoxylatnatrium    wer  den in Wasser gelöst,     zunächst    7,4 g     Glycid          eingerührt,    wobei die     Temperatur    von 19 auf  21       steigt,        und    nach dem Abkühlen 4,4 g       Äthylenoxyd    hinzugefügt. Die beiden     Alky-          lenoxyde        können    auch in     umgekehrter    Rei  henfolge     eingeführt    werden.

   Aus der klaren  gelben Lösung scheidet sich auf Zusatz von  Äthylalkohol     und    Äther ein ,gelber Nieder  schlag von 3-(Dioxypropyl-oxyäthyl)-amino       4,4'-dioxyarsen6benzol=3'-aminoformaldehyd-          sulfoxylatnatrium       
EMI0002.0001     
    aus,, der abgesaugt und gegebenenfalls  zwecks weiterer Reinigung in Wasser .gelöst  und     wiederum    mittels Äthylalkohol und  Äther gefällt wird.

       Das        Sulfoxylat    löst sich       leicht    in     Wasser        mit    schwach     alkalischer          Reaktion    und     enthält    etwa<B>19%</B> Arsen.



  Process for the preparation of a 3- (diogypropyl-ogyäthyl) -amino-4-ogy-3'-amino-4'-ozyarsenobenzolsulfogylats. The main patent relates to a process for the production of 3- (bis - dioxypropyl) amino-4,4 '- @ dioxyarsenobenzene-, 3'-aminomonoforma1, dehyd @ sulfoxylate sodium, which is characterized by @ that one glycide with a Solution of 3;

  3 '- Diamino - 4,4' dioxyarsenobenzene monoformaldehyde sulfoxylate sodium brings to implementation.



  It has now been found that a compound of equally valuable pharmacological properties can also be obtained if a solution of 3,3'-di-amino-4,4'-dioxyarsenobenzene monoformal - dehydsulfoxylate sodium, glycide and itethylene oxide is used can interact.

   The 3 - (dioxypropy 1-oxyethyl) - amino-4,4'-dioxyarsenobenzene- 3'-aminoformaldehyde, sulfoxylate sodium obtainable in this way forms a yellow powder that is easily soluble in water and insoluble in ether and ethyl alcohol: It is said to be used as a medicinal product .



  <I> Example: </I> 77.5 g of 3 "3'-diamino-4,4'-dioxyarsenoben- zolmonoforma1, sodium sulfoxylate are dissolved in water, 7.4 g of glycide are first stirred in, the temperature rising from 19 to 21 rises, and after cooling, 4.4 g of ethylene oxide are added. The two alkylene oxides can also be introduced in the reverse order.

   On the addition of ethyl alcohol and ether, a yellow precipitate of 3- (dioxypropyl-oxyethyl) -amino 4,4'-dioxyarsen6benzene = 3'-aminoformaldehyde sulfoxylate sodium separates from the clear yellow solution
EMI0002.0001
    from ,, which is sucked off and, if necessary, dissolved in water for the purpose of further cleaning and then precipitated again using ethyl alcohol and ether.

       The sulfoxylate dissolves easily in water with a weakly alkaline reaction and contains about <B> 19% </B> arsenic.

Claims (1)

PATENTANSPRUCH: Verfahren, zur Herstellung einer Arseno- verbindung, dadurch gekennzeichnet, dass man eine Lösung von 3,3'-Diamino-4,4'- ,dioxyamenobenzolmonoformaldehydsulfoxy- latnatrium, Glycid und Äthylenoxyd auf einander einwirken lässt. PATENT CLAIM: Process for producing an arsenic compound, characterized in that a solution of 3,3'-diamino-4,4'-, dioxyamenobenzene monoformaldehyde sulfoxylate sodium, glycide and ethylene oxide is allowed to act on one another. Die neue Verbindung bildet ein in Was ser leicht lösliches, in Äther und Äthyl- alkohol unlösliches gelbes Pulver. Sie soll als Heilmittel Verwendung finden. The new compound forms a yellow powder that is easily soluble in water and insoluble in ether and ethyl alcohol. It is said to be used as a remedy.
CH192068D 1934-03-10 1934-12-12 Process for the preparation of a 3- (dioxypropyl-oxyethyl) -amino-4-oxy-3'-amino-4'-oxyarsenobenzene sulfoxylate. CH192068A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE192068X 1934-03-10
CH186394T 1934-12-12

Publications (1)

Publication Number Publication Date
CH192068A true CH192068A (en) 1937-07-15

Family

ID=25721360

Family Applications (1)

Application Number Title Priority Date Filing Date
CH192068D CH192068A (en) 1934-03-10 1934-12-12 Process for the preparation of a 3- (dioxypropyl-oxyethyl) -amino-4-oxy-3'-amino-4'-oxyarsenobenzene sulfoxylate.

Country Status (1)

Country Link
CH (1) CH192068A (en)

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