CH169578A - Process for the preparation of the salt of 2,3-dimethoxy-6-nitro-9- (Y-diethylamino-B-oxy-propylamino) -acridine with p-glycolylaminobenzolaric acid. - Google Patents

Process for the preparation of the salt of 2,3-dimethoxy-6-nitro-9- (Y-diethylamino-B-oxy-propylamino) -acridine with p-glycolylaminobenzolaric acid.

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Publication number
CH169578A
CH169578A CH169578DA CH169578A CH 169578 A CH169578 A CH 169578A CH 169578D A CH169578D A CH 169578DA CH 169578 A CH169578 A CH 169578A
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CH
Switzerland
Prior art keywords
salt
nitro
propylamino
dimethoxy
oxy
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Application number
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German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
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Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH169578A publication Critical patent/CH169578A/en

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Description

  

      Verfahren        zur    Herstellung des Salzes von     2.3-Dimethoxy-6-nitro-9-(i-diäthylamino-@-oxy-          propylamino)-aeridin    mit     p-Glykolylaminobenzolarsinsäure.       Es wurde gefunden, dass     man    durch Um  setzung der Salze von     Aeridinbasen    mit Sal  zen von organischen     Arsinsäuren,    welche       nieht        ausschliesslich    durch primäre     Amino-          gruppen    substituiert sind, zu Verbindungen       ,elangt,

      die gegenüber den Ausgangsstoffen  erhebliche Vorzüge aufweisen. Eine beson  ders gute Wirksamkeit weisen unter anderem  solche Verbindungen auf, die unter Verwen  dung von     Arsinsäuren,    welche irgendwelche  Metalle komplex gebunden enthalten, her  gestellt sind. Die neuen Verbindungen sind  insbesondere gegen     Streptokokkeninfektionen,          Ilowie    Tierkrankheiten, wie     Piroplasmose,          wirksam.     



  Gegenstand der vorliegenden Erfindung  ist ein Verfahren zur Herstellung des Sal  zes von ? .     3-Dimetlioxy-6-nitro-9-(y-diätliyl-          amino-ss-oxy-propylamino)-acridin    mit     p-Gly-          kolylaininobenzola.rsinsäure,    das dadurch ge  kennzeichnet ist, dass man eine Lösung eines    Salzes von     2.3-Dimethoxy-6-nitro-9-(y-di-          äthylamino-ss-oxypropylamino)-acridin    mit  einer Lösung, eines Salzes -von     p-Glykolyl-          aminobenzolarsinsäure    umsetzt.  



  Die so erhaltene neue Verbindung ist ein  braunes Pulver, leicht löslich in Wasser,  wenig löslich in Methylalkohol und kaum  löslich in Äthylalkohol. Sie soll als Arznei  mittel Verwendung finden.    <I>Beispiel:</I>    Zu einer Lösung von 18,3     gr        p-glykolyl-          aminobenzolarsinsaurem    Natrium in 25 cm'  Methylalkohol gibt man eine Lösung von  12,8     gr    \2 . 3-Dimethoxy-6-nitro-9-(y-diäthyl       amino-ss-oxy-propylamino)-acridindichlorhy-          drat    in 40 cm' Methylalkohol und 6 cm'  Wasser. Nach kurzem Aufkochen wird ab  gekühlt und durch Zugabe von Aceton das  gebildete Salz als braunes Pulver abgeschie  den.

   Es ist leicht löslich in Wasser, wenig      löslich in Methylalkohol und kaum löslich  in Äthylalkohol.



      Process for the preparation of the salt of 2,3-dimethoxy-6-nitro-9- (i-diethylamino - @ - oxy-propylamino) -aeridine with p-glycolylaminobenzolaric acid. It has been found that by reacting the salts of aeridine bases with salts of organic arsinic acids, which are not exclusively substituted by primary amino groups, compounds are obtained,

      which have considerable advantages over the starting materials. A particularly good effectiveness have, inter alia, those compounds that are made using arsinic acids, which contain any metals in complex bonds. The new compounds are particularly effective against streptococcal infections, Ilowie animal diseases such as piroplasmosis.



  The present invention relates to a process for the preparation of the salt of? . 3-Dimetlioxy-6-nitro-9- (y-dietliyl-amino-ss-oxy-propylamino) -acridine with p-Gly- kolylaininobenzola.rsinsäure, which is characterized in that a solution of a salt of 2,3-dimethoxy -6-nitro-9- (y-di- äthylamino-ss-oxypropylamino) -acridine with a solution of a salt of p-glycolyl aminobenzolaric acid is reacted.



  The new compound thus obtained is a brown powder, easily soluble in water, sparingly soluble in methyl alcohol and hardly soluble in ethyl alcohol. It should be used as a medicament. <I> Example: </I> A solution of 12.8 g \ 2 is added to a solution of 18.3 g of sodium p-glycolyl aminobenzenesic acid in 25 cm of methyl alcohol. 3-Dimethoxy-6-nitro-9- (γ-diethyl amino-ss-oxy-propylamino) -acridinedichlorohydrate in 40 cm 'of methyl alcohol and 6 cm' of water. After a short boil, the mixture is cooled and the salt formed is deposited as a brown powder by adding acetone.

   It is easily soluble in water, slightly soluble in methyl alcohol and hardly soluble in ethyl alcohol.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung des Salzes von 2 . 3-Dimethoxy-6-nitro-9-(y-diätliyl= amino-ss-oxy-propylamino)-acridi.n mit p-Gly- kolylaminobenzolarsinsäure, dadurch gekenn zeichnet, dass man eine Lösung eines Salzes von 2 . ä-Dimethoxy-6-nitro-9-(y-diäthyl- amino-ss-oxy-propylamino)-acridin mit einer Lösung eines Salzes von p-Gly kolylamino- benzolarsinsäure umsetzt. Die so erhaltene neue Verbindung ist ein braunes Pulver, leicht löslich in Wasser, wenig löslich in Methylalkohol und kaum löslich in Äthylalkohol. PATENT CLAIM: Process for the production of the salt of 2. 3-Dimethoxy-6-nitro-9- (y-dietliyl = amino-ss-oxy-propylamino) -acridi.n with p-glycolylaminobenzolaric acid, characterized in that a solution of a salt of 2. ä-Dimethoxy-6-nitro-9- (γ-diethylamino-ss-oxy-propylamino) -acridine is reacted with a solution of a salt of p-Gly kolylamino benzolar acid. The new compound thus obtained is a brown powder, easily soluble in water, sparingly soluble in methyl alcohol and hardly soluble in ethyl alcohol. Sie soll als Arznei mittel Verwendung finden. It should be used as a medicament.
CH169578D 1931-07-04 1932-07-02 Process for the preparation of the salt of 2,3-dimethoxy-6-nitro-9- (Y-diethylamino-B-oxy-propylamino) -acridine with p-glycolylaminobenzolaric acid. CH169578A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE169578X 1931-07-04
CH162292T 1932-07-02

Publications (1)

Publication Number Publication Date
CH169578A true CH169578A (en) 1934-05-31

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Family Applications (1)

Application Number Title Priority Date Filing Date
CH169578D CH169578A (en) 1931-07-04 1932-07-02 Process for the preparation of the salt of 2,3-dimethoxy-6-nitro-9- (Y-diethylamino-B-oxy-propylamino) -acridine with p-glycolylaminobenzolaric acid.

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CH (1) CH169578A (en)

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