CH188808A - Process for the preparation of the lactate of 3,6-diamino-10-methylacridinium hydroxide. - Google Patents

Process for the preparation of the lactate of 3,6-diamino-10-methylacridinium hydroxide.

Info

Publication number
CH188808A
CH188808A CH188808DA CH188808A CH 188808 A CH188808 A CH 188808A CH 188808D A CH188808D A CH 188808DA CH 188808 A CH188808 A CH 188808A
Authority
CH
Switzerland
Prior art keywords
lactate
diamino
methylacridinium
preparation
hydroxide
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH188808A publication Critical patent/CH188808A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Herstellung des     Laktats    des     3,6-Diamino-10-methylacridiniumhydroayds.       In dem Hauptpatent ist ein Verfahren  zur Herstellung des Acetats des     3,6-Diamino-          10-methylacridiniumhy        droxyds    beschrieben,  welches dadurch gekennzeichnet ist, dass man       3,6-Diamino-10-methylacridiniumchlorid    in  das entsprechende     Bicarbonat    überführt und  dieses in Essigsäure löst.  



  Es wurde nun gefunden, dass man das       Laktat    des     3,6-Diamino-10-methylacridinium-          hydroxyds    in analoger Weise dadurch her  stellen kann, dass man das aus     3,6-Diamino-          10-methylacridiniumchlorid    erhaltene     Bicar-          bonat    in Milchsäure löst und aus der     Lösung     das     Laktat    durch Zugabe von Aceton ab  scheidet.

   Die neue Verbindung bildet gelbe  bis gelbrote Kristalle, die in Wasser sehr  leicht, in     Methyl-    und Äthylalkohol     sch-v#,e-          rer,    und in Äther oder Aceton unlöslich sind.  



  Das neue Produkt soll als Heilmittel  Verwendung finden.  



  <I>Beispiel:</I>  Man löst     20g        3,6-I)iamino-10-methylacri-          diniumclilorid    und 20 g     Natriumcarbonat    in  500 cm' heissem Wasser auf und leitet in die  Flüssigkeit Kohlendioxyd bis zur Sättigung  ein. Nach kurzer Zeit kristallisiert aus der    erkalteten Lösung das saure Karbonat aus,  das in seinen Eigenschaften der in dem Bei  spiel des Hauptpatentes beschriebenen Ver  bindung entspricht. Das Produkt wird im  molekularen Verhältnis in verdünnter Milch  säure gelöst und die Lösung     mit    Aceton ver  setzt. Nach einiger Zeit kristallisiert das       Laktat    aus.



  Process for the preparation of the lactate of 3,6-diamino-10-methylacridinium hydroxide. The main patent describes a process for the preparation of the acetate of 3,6-diamino-10-methylacridinium hydroxide, which is characterized in that 3,6-diamino-10-methylacridinium chloride is converted into the corresponding bicarbonate and this is dissolved in acetic acid.



  It has now been found that the lactate of 3,6-diamino-10-methylacridinium hydroxide can be produced in an analogous manner by dissolving the bicarbonate obtained from 3,6-diamino-10-methylacridinium chloride in lactic acid and the lactate separates from the solution by adding acetone.

   The new compound forms yellow to yellow-red crystals which are very easily soluble in water, insoluble in methyl and ethyl alcohol, and in ether or acetone.



  The new product should be used as a remedy.



  <I> Example: </I> Dissolve 20 g of 3,6-I) iamino-10-methylacridinium chloride and 20 g of sodium carbonate in 500 cm 'of hot water and introduce carbon dioxide into the liquid until it is saturated. After a short time, the acidic carbonate crystallizes out of the cooled solution, the properties of which correspond to the connection described in the example of the main patent. The product is dissolved in dilute lactic acid in a molecular ratio and the solution is added with acetone. After a while, the lactate crystallizes out.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung des Laktats des 3,6-Diamino-10-methylacridiniumhydr- oxyds, dadurch gekennzeichnet, dass man das aus 3,6-Di@imino-10-methylaoridiniumchlorid erhaltene Bicarbonat in Milchsäure löst und aus der Lösung das Laktat durch Zugabe von Aceton abscheidet. Die neue Verbindung bildet gelbe bis gelbrote Kristalle, die in Wasser sehr leicht, in klethyl- und Athyl- alkohol schwerer, und in Äther oder Aceton unlöslich sind. PATENT CLAIM: Process for the preparation of the lactate of 3,6-diamino-10-methylacridiniumhydroxide, characterized in that the bicarbonate obtained from 3,6-di @ imino-10-methylaoridinium chloride is dissolved in lactic acid and the lactate is passed through from the solution Adding acetone separates. The new compound forms yellow to yellow-red crystals, which are very light in water, more difficult in ethyl and ethyl alcohol, and insoluble in ether or acetone. Die neue Verbindung soll als Heilmittel Verwendung finden. The new compound is said to be used as a remedy.
CH188808D 1935-03-15 1935-03-15 Process for the preparation of the lactate of 3,6-diamino-10-methylacridinium hydroxide. CH188808A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH188808T 1935-03-15
CH184423T 1935-03-15

Publications (1)

Publication Number Publication Date
CH188808A true CH188808A (en) 1937-01-15

Family

ID=25721033

Family Applications (1)

Application Number Title Priority Date Filing Date
CH188808D CH188808A (en) 1935-03-15 1935-03-15 Process for the preparation of the lactate of 3,6-diamino-10-methylacridinium hydroxide.

Country Status (1)

Country Link
CH (1) CH188808A (en)

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