CH113833A - Process for the preparation of a complex bismuth compound of the reaction product obtainable from tyrosine and formaldehyde. - Google Patents

Process for the preparation of a complex bismuth compound of the reaction product obtainable from tyrosine and formaldehyde.

Info

Publication number
CH113833A
CH113833A CH113833DA CH113833A CH 113833 A CH113833 A CH 113833A CH 113833D A CH113833D A CH 113833DA CH 113833 A CH113833 A CH 113833A
Authority
CH
Switzerland
Prior art keywords
tyrosine
formaldehyde
reaction product
preparation
product obtainable
Prior art date
Application number
Other languages
German (de)
Inventor
Flora Chemische Fabrik
Original Assignee
Chem Fab Flora
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Fab Flora filed Critical Chem Fab Flora
Publication of CH113833A publication Critical patent/CH113833A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/94—Bismuth compounds

Description

  

  Verfahren zur Darstellung einer komplexen     Wismutverbindung    des aus     Tyrosin    und  Formaldehyd erhältlichen Reaktionsproduktes.    Komplexe     Wismutverbindungen    des     Ty-          rosins    und seiner Derivate sind bis jetzt nicht  bekannt.  



  Versetzt man das durch     Behandeln    von  Formaldehyd mit     Tyrosin    erhältliche Pro  tlukt in wässeriger Lösung mit Essigsäure  und zweckmässig frisch     gefälltem    Wismut  hydroxyd, erwärmt, filtriert, dampft im Va  kuum ein, löst den Rückstand in wenig Was  ser, neutralisiert mit     verdtinnter    Natronlauge  und fällt die wässerige Lösung durch     Einrüh-          ren.    in Alkohol, so. erhält man ein Pulver,  welches etwa 7 % Wismut in komplexer Form  enthält. Das Produkt stellt ein gelbes, in       Wasser    leicht lösliches Produkt dar.     Die     wässerige Lösung reagiert neutral bis schwach  alkalisch.  



  <I>Beispiel:</I>  Zu einer wässerigen Lösung des durch  Behandeln von 10     gr        Tyrosin    mit 40     gr        For-          maldehyd    und 10     gr    Natronlauge von<B>30</B> erhältlichen Einwirkungsproduktes werden  20 am<B>,</B> Essigsäure von 80      /a    und frisch ge  fälltes     Wismuthydroxyd    im Überschuss zu  gesetzt und das Ganze drei. Stunden auf dem  Wasserbade erwärmt.

   Das Filtrat     wird    im    Vakuum     eingedampft,    der     Rückstand    mit  wenig Wasser gelöst, mit verdünnter Natron  lauge     neutralisiert    und durch Einrühren in  ,die zirka fünffache Menge Alkohol gefällt.  



  Neutral bis schwach alkalisch reagieren-.  ,des, gelbes Pulver. Es soll therapeutische  Verwendung finden.



  Process for the preparation of a complex bismuth compound of the reaction product obtainable from tyrosine and formaldehyde. Complex bismuth compounds of tyrosine and its derivatives are not yet known.



  If the product, which can be obtained by treating formaldehyde with tyrosine, is mixed in aqueous solution with acetic acid and suitably freshly precipitated bismuth hydroxide, heated, filtered, evaporated in a vacuum, the residue is dissolved in a little water, neutralized with diluted sodium hydroxide solution and the aqueous solution is precipitated Solution by stirring. In alcohol, see above. a powder is obtained which contains about 7% bismuth in complex form. The product is a yellow product that is easily soluble in water. The aqueous solution has a neutral to slightly alkaline reaction.



  <I> Example: </I> To an aqueous solution of the action product obtainable by treating 10 g tyrosine with 40 g formaldehyde and 10 g sodium hydroxide solution of <B> 30 </B>, 20 am B> Acetic acid of 80 / a and freshly precipitated bismuth hydroxide are added in excess and the whole three. Heated for hours on the water bath.

   The filtrate is evaporated in vacuo, the residue is dissolved with a little water, neutralized with dilute sodium hydroxide solution and about five times the amount of alcohol is precipitated by stirring into it.



  React neutral to slightly alkaline. , des, yellow powder. It should find therapeutic use.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung einer kom plexen Wismutverbindung des aus Tyrosin und Formaldehyd erhältlichen Reaktionspro duktes, dadurch gekennzeichnet, dass man die wässerige Lösung des Reaktionsproduktes von Tyrosin mit Formaldehyd mit Essig säure und Wismuthydroxyd erwärmt, fil triert, im Vakuum eindampft, den Rückstand in wenig Wasser löst, mit. verdünnter Natron lauge neutralisiert und durch Einrühren in Alkohol fällt. PATENT CLAIM: Process for the production of a complex bismuth compound of the reaction product obtainable from tyrosine and formaldehyde, characterized in that the aqueous solution of the reaction product of tyrosine with formaldehyde is heated with acetic acid and bismuth hydroxide, filtered, evaporated in vacuo, the residue in a little Water dissolves with. dilute sodium hydroxide solution neutralized and falls by stirring into alcohol. Die Verbindung ist ein gelbes, amorphes, in -Wasser leicht. lösliches, cä. 7 % Wismut enthaltendes Pulver, deren Lösung neutral bis schwach alkalisch reagiert. The compound is a yellow, amorphous, easily in -water. soluble, cä. Powder containing 7% bismuth, the solution of which has a neutral to slightly alkaline reaction.
CH113833D 1924-11-07 1924-11-07 Process for the preparation of a complex bismuth compound of the reaction product obtainable from tyrosine and formaldehyde. CH113833A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH113833T 1924-11-07

Publications (1)

Publication Number Publication Date
CH113833A true CH113833A (en) 1926-02-16

Family

ID=4372982

Family Applications (1)

Application Number Title Priority Date Filing Date
CH113833D CH113833A (en) 1924-11-07 1924-11-07 Process for the preparation of a complex bismuth compound of the reaction product obtainable from tyrosine and formaldehyde.

Country Status (1)

Country Link
CH (1) CH113833A (en)

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