CH191341A - Process for the preparation of a theophylline derivative of a urethane series mercury compound. - Google Patents
Process for the preparation of a theophylline derivative of a urethane series mercury compound.Info
- Publication number
- CH191341A CH191341A CH191341DA CH191341A CH 191341 A CH191341 A CH 191341A CH 191341D A CH191341D A CH 191341DA CH 191341 A CH191341 A CH 191341A
- Authority
- CH
- Switzerland
- Prior art keywords
- compound
- preparation
- theophylline
- urethane series
- mercury compound
- Prior art date
Links
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical class O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 title claims description 10
- 229940100892 mercury compound Drugs 0.000 title claims description 5
- -1 urethane series mercury compound Chemical class 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 6
- 239000013078 crystal Substances 0.000 claims description 3
- 150000002731 mercury compounds Chemical class 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 229960000278 theophylline Drugs 0.000 claims description 3
- 208000004880 Polyuria Diseases 0.000 claims description 2
- 230000001882 diuretic effect Effects 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 150000003673 urethanes Chemical class 0.000 claims description 2
- 239000007858 starting material Substances 0.000 claims 1
- 239000012458 free base Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/10—Mercury compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Herstellung eines Theophyllinderivates einer Quecksilberverbindung der Urethanreihe. Es wurde gefunden, dass man zu einem Theophyllinderivat einer Quecksilberverbin dung der Urethanreihe gelangen kann, wenn man auf eine Verbindung, die das Radikal der Formel
EMI0001.0006
enthält, wie z. B. die freie Base, sowie ihre Salze, Theophyllin einwirken lässt.
Die auf diese Weise gewannene Ver bindung bildet ein weisses Kristallpulver. Die neue Verbindung zeichnet sich durch ihre starke diuretische Wirkung bei guter Verträglichkeit aua. Sie soll therapeutische Verwendung finden.
<I>Beispiel:</I> 40,5 Teile N-Allyläthylui@ethan-mercuri- acetat werden in wässeriger Lösung mit 18 Teilen Theophyllin umgesetzt, die Lösung in i Vakuum zur Trockne eingedampft und so die neue Quecksilberverbindung der wahr scheinlichen Zusammensetzung Ce,Hi 2 0.g N-Hg-C7H7 02N4 als hygroskopisches Kristallpulver erhalten.
An Stelle vor) N-Allyläthylurethan-mer- curiacetat kann man auch von einem andern Salz, wie z. ss. vom Propionat, Butyrat oder von der freien Base selbst ausgehen.
Process for the preparation of a theophylline derivative of a urethane series mercury compound. It has been found that a theophylline derivative of a mercury compound of the urethane series can be obtained by reacting to a compound which has the radical of the formula
EMI0001.0006
contains, such as B. the free base and its salts, theophylline can act.
The compound obtained in this way forms a white crystal powder. The new compound is characterized by its strong diuretic effect and good tolerance aua. It should find therapeutic use.
<I> Example: </I> 40.5 parts of N-Allyläthylui @ ethan-mercuri- acetate are reacted in aqueous solution with 18 parts of theophylline, the solution is evaporated to dryness in a vacuum and so the new mercury compound with the probable composition Ce , Hi 2 0.g N-Hg-C7H7 02N4 obtained as a hygroscopic crystal powder.
Instead of before) N-Allyläthylurethan-mer- curiacetat you can also use another salt, such as. ss. start from propionate, butyrate or from the free base itself.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH191341T | 1934-11-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH191341A true CH191341A (en) | 1937-06-15 |
Family
ID=4437557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH191341D CH191341A (en) | 1934-11-03 | 1934-11-03 | Process for the preparation of a theophylline derivative of a urethane series mercury compound. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH191341A (en) |
-
1934
- 1934-11-03 CH CH191341D patent/CH191341A/en unknown
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