CH195563A - Process for the preparation of a theophylline derivative of a urethane series mercury compound. - Google Patents

Process for the preparation of a theophylline derivative of a urethane series mercury compound.

Info

Publication number
CH195563A
CH195563A CH195563DA CH195563A CH 195563 A CH195563 A CH 195563A CH 195563D A CH195563D A CH 195563DA CH 195563 A CH195563 A CH 195563A
Authority
CH
Switzerland
Prior art keywords
sep
preparation
theophylline
mercury compound
urethane series
Prior art date
Application number
Other languages
German (de)
Inventor
Gesellschaft Fuer Chemis Basel
Original Assignee
Chem Ind Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Ind Basel filed Critical Chem Ind Basel
Publication of CH195563A publication Critical patent/CH195563A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/10—Mercury compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Herstellung eines     Theophyllin-Derivates    einer       Quecksilberverbindung    der     Urethanreihe.       Es wurde gefunden, dass     man    zu einem       Theophyllin-Derivat    einer Quecksilberver  bindung der     Urethanreihe    gelangen kann,  wenn man auf eine Verbindung, -die das  Radikal der     Formel     
EMI0001.0008     
         enthält,    wie z. B. die freie Base, sowie ihre  Salze,     Theophyllin    einwirken lässt.  



  Die auf     diese    Weise     gewonnene    Verbin  dung der Formel       C7H1403N-Hg-C7H702N4     bildet weisse Kristalle vom F. 173 bis 175  .  Die neue Verbindung zeichnet sich .durch  ihre starke     diuretische    Wirkung bei     guter     Verträglichkeit aus.     .Sie    soll therapeutische  Verwendung finden.  



  <I>Beispiel:</I>  42 Teile     N-Allyl-isopropylurethan-mer-          curiacetat    setzt man mit 20 Teilen Theo-         phyllin    in wässeriger Lösung um, dampft die  Lösung im Vakuum zur Trockne ein     und    kri  stallisiertden Rückstand aus Wasser um. Die  neue Verbindung der Formel       C7111403N-Hg-C7H702L\4     bildet weisse Kristalle vom F. 173 bis<B>175'.</B>  An Stelle von     N-Allyl-isopropylurethan-          mercuriacetat    kann man auch von einem an  dern Salz     wie    z. B. vom     Propionat,        Butyrat     oder von der freien Base selbst ausgehen.



  Process for the preparation of a theophylline derivative of a urethane series mercury compound. It has been found that you can get to a theophylline derivative of a Mercury Ver bond of the urethane series, if you look at a compound -the radical of the formula
EMI0001.0008
         contains, such as B. the free base and its salts, theophylline can act.



  The compound of the formula C7H1403N-Hg-C7H702N4 obtained in this way forms white crystals with a F. 173 to 175. The new compound is characterized by its strong diuretic effect and good tolerance. It should find therapeutic use.



  <I> Example: </I> 42 parts of N-allyl isopropyl urethane mercuriacetate are reacted with 20 parts of theophylline in aqueous solution, the solution is evaporated to dryness in vacuo and the residue is crystallized from water. The new compound of the formula C7111403N-Hg-C7H702L \ 4 forms white crystals from F. 173 to 175 ' . B. start from propionate, butyrate or the free base itself.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines Theo- phyllin-derivates einer Quecksilberverbin dung der Urethanreihe, dadurch gekennzeich net, dass man auf eine Verbindung, die das Radikal der Formel EMI0001.0031 enthält, Theophyllin einwirken lässt. EMI0002.0001 Die <SEP> auf <SEP> diese <SEP> Weise <SEP> gewonnene <SEP> Verbin ciung <SEP> der <SEP> Formel <tb> C;Hi40#iN-Hg-C7H7012N4 <tb> l; PATENT CLAIM: Process for the production of a theophylline derivative of a mercury compound of the urethane series, characterized in that a compound containing the radical of the formula EMI0001.0031 contains theophylline. EMI0002.0001 The <SEP> <SEP> this <SEP> way <SEP> obtained <SEP> connection <SEP> of the <SEP> formula <tb> C; Hi40 # iN-Hg-C7H7012N4 <tb> l; ildet <SEP> weisse <SEP> Kristalle <SEP> vom <SEP> F. <SEP> 173 <SEP> bis <SEP> <B>175'.</B> <tb> Die <SEP> neue <SEP> Verbindung <SEP> zeichnet <SEP> sieh <SEP> durch <tb> ihre <SEP> starke <SEP> diuretische <SEP> Wirkung <SEP> bei <SEP> guter <tb> Verträglichkeit <SEP> aus. <SEP> Sie <SEP> soll <SEP> therapeutisch Verwendung <SEP> finden. EMI0002.0002 UNTERANSPRUCH: <tb> Verfahren <SEP> nach <SEP> Patentanspruch. <SEP> dadurch <tb> gekennzeichnet, <SEP> dass <SEP> man <SEP> als <SEP> Ausgangsstoff <tb> N-Allyl-isopropyluretban-mereuriacetat <SEP> ver weIldet. Forms <SEP> white <SEP> crystals <SEP> from <SEP> F. <SEP> 173 <SEP> to <SEP> <B> 175 '. </B> <tb> The <SEP> new <SEP> connection <SEP> identifies <SEP> see <SEP> <tb> their <SEP> strong <SEP> diuretic <SEP> effect <SEP> with <SEP> good <tb> Compatibility <SEP> off. <SEP> You <SEP> should <SEP> find therapeutic use <SEP> EMI0002.0002 SUBClaim: <tb> Method <SEP> according to <SEP> patent claim. <SEP> thereby <tb> marked, <SEP> that <SEP> man <SEP> as <SEP> starting material <tb> N-allyl-isopropyluretban-mereuriacetate <SEP> tinged.
CH195563D 1934-11-03 1934-11-03 Process for the preparation of a theophylline derivative of a urethane series mercury compound. CH195563A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH195563T 1934-11-03
CH191341T 1934-11-03

Publications (1)

Publication Number Publication Date
CH195563A true CH195563A (en) 1938-01-31

Family

ID=25722103

Family Applications (1)

Application Number Title Priority Date Filing Date
CH195563D CH195563A (en) 1934-11-03 1934-11-03 Process for the preparation of a theophylline derivative of a urethane series mercury compound.

Country Status (1)

Country Link
CH (1) CH195563A (en)

Similar Documents

Publication Publication Date Title
DE594085C (en) Process for the production of basic esters of fatty acids
CH195563A (en) Process for the preparation of a theophylline derivative of a urethane series mercury compound.
CH195562A (en) Process for the preparation of a theophylline derivative of a urethane series mercury compound.
CH191341A (en) Process for the preparation of a theophylline derivative of a urethane series mercury compound.
DE538375C (en) Process for the preparation of organic mercury compounds
AT137670B (en) Process for the representation of organic mercury bonds.
AT145519B (en) Process for the preparation of complex compounds of secondary or tertiary oxyalkylamines.
AT201609B (en) Process for the preparation of new sulfonylureas
CH183121A (en) Process for the preparation of a heterocyclic mercury compound.
CH183065A (en) Process for the preparation of benzilic acid-2-diethylaminoethanol ester.
CH234986A (en) Process for the preparation of a new therapeutically effective amidine.
CH188235A (en) Process for the preparation of a heterocyclic mercury compound.
CH194678A (en) Method for producing a urethane series mercury compound.
CH263037A (en) Process for the preparation of a new derivative of 2-oxy-5-aminobenzoic acid.
CH235951A (en) Process for the preparation of a new therapeutically effective amidine.
CH199681A (en) Method for producing a urethane series mercury compound.
AT213896B (en) Process for the preparation of new, basic substituted thioethers of pyrimidines
CH193834A (en) Method for producing a urethane series mercury compound.
CH234982A (en) Process for the preparation of a new therapeutically effective amidine.
CH183801A (en) Process for the preparation of a heterocyclic mercury compound.
CH193835A (en) Method for producing a urethane series mercury compound.
CH188440A (en) Method for producing a urethane series mercury compound.
CH188236A (en) Process for the preparation of a urethane of pyridine-3-carboxylic acid.
CH156270A (en) Process for the preparation of a double compound of pentamethylenetetrazole.
CH156938A (en) Process for the preparation of a double compound of the pyridine series.