CH188235A - Process for the preparation of a heterocyclic mercury compound. - Google Patents
Process for the preparation of a heterocyclic mercury compound.Info
- Publication number
- CH188235A CH188235A CH188235DA CH188235A CH 188235 A CH188235 A CH 188235A CH 188235D A CH188235D A CH 188235DA CH 188235 A CH188235 A CH 188235A
- Authority
- CH
- Switzerland
- Prior art keywords
- compound
- heterocyclic
- carboxylic acid
- preparation
- mercury compound
- Prior art date
Links
- 229940100892 mercury compound Drugs 0.000 title claims description 5
- -1 heterocyclic mercury compound Chemical class 0.000 title claims description 4
- 238000000034 method Methods 0.000 title claims description 3
- 238000002360 preparation method Methods 0.000 title description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 4
- ABBZJHFBQXYTLU-UHFFFAOYSA-N but-3-enamide Chemical compound NC(=O)CC=C ABBZJHFBQXYTLU-UHFFFAOYSA-N 0.000 claims description 3
- 239000013078 crystal Substances 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 230000002421 anti-septic effect Effects 0.000 claims description 2
- 238000000354 decomposition reaction Methods 0.000 claims description 2
- 239000002934 diuretic Substances 0.000 claims description 2
- 230000001882 diuretic effect Effects 0.000 claims description 2
- 235000019441 ethanol Nutrition 0.000 claims description 2
- BRMYZIKAHFEUFJ-UHFFFAOYSA-L mercury diacetate Chemical compound CC(=O)O[Hg]OC(C)=O BRMYZIKAHFEUFJ-UHFFFAOYSA-L 0.000 claims description 2
- 150000007530 organic bases Chemical class 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 235000011121 sodium hydroxide Nutrition 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 150000002731 mercury compounds Chemical class 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/10—Mercury compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Herstellung einer heterocyelischen Quecksilberverbindung. Es wurde gefunden, dass man zu einer neuen heterocyclischen Quecksilberverbindung gelangen kann, wenn man auf das Pyridin- 3 -carbonsäure - 2 - carbonsäureallylamid Mer- curiacetat in (Regenwart von Äthylalkohol einwirken lässt.
Die auf diese Weise gewonnene Verbin dung der Formel
EMI0001.0009
bildet ein weisses Kristallpulver, das gegen Natronlauge beständig ist und einen Zer setzungspunkt von<B>1310</B> zeigt. Die neue Verbindung bildet mit Alkalien, organischen Basen und dergleichen wasserlösliche Salze.
Die neue Verbindung zeichnet sich durch ihre starke diuretisehe und antiseptische Wirkung bei guter Verträglichkeit aus. Sie soll therapeutische Verwendung finden. <I>Beispiel:</I> 2 Teile Pyridin-3-carbonsäure-2-carbon- säureallylamid werden in äthylalkoholischer Lösung mit 3 Teilen DZercuriacetat umgesetzt. Die neue Quecksilberverbindung der in der Einleitung erwähnten Formel scheidet sich als Öl aus, das beim Reiben zu einem weissen Kristallpulver erstarrt.
Process for the preparation of a heterocyclic mercury compound. It has been found that a new heterocyclic mercury compound can be obtained if the pyridine-3-carboxylic acid 2-carboxylic acid allylamide is allowed to act on mercuriacetate in (Regenwart of ethyl alcohol.
The compound of the formula obtained in this way
EMI0001.0009
forms a white crystal powder that is resistant to caustic soda and has a decomposition point of <B> 1310 </B>. The new compound forms water-soluble salts with alkalis, organic bases and the like.
The new compound is characterized by its strong diuretic and antiseptic effect and good tolerance. It should find therapeutic use. <I> Example: </I> 2 parts of pyridine-3-carboxylic acid-2-carboxylic acid allylamide are reacted with 3 parts of Cercuriacetate in an ethyl alcoholic solution. The new mercury compound of the formula mentioned in the introduction separates itself as an oil, which solidifies to a white crystal powder when rubbed.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH188235T | 1935-11-11 | ||
| CH176757T | 1935-11-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH188235A true CH188235A (en) | 1936-12-15 |
Family
ID=25719884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH188235D CH188235A (en) | 1935-11-11 | 1935-11-11 | Process for the preparation of a heterocyclic mercury compound. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH188235A (en) |
-
1935
- 1935-11-11 CH CH188235D patent/CH188235A/en unknown
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