CH183121A - Process for the preparation of a heterocyclic mercury compound. - Google Patents
Process for the preparation of a heterocyclic mercury compound.Info
- Publication number
- CH183121A CH183121A CH183121DA CH183121A CH 183121 A CH183121 A CH 183121A CH 183121D A CH183121D A CH 183121DA CH 183121 A CH183121 A CH 183121A
- Authority
- CH
- Switzerland
- Prior art keywords
- heterocyclic
- preparation
- mercury compound
- compound
- new compound
- Prior art date
Links
- 229940100892 mercury compound Drugs 0.000 title description 5
- -1 heterocyclic mercury compound Chemical class 0.000 title description 4
- 238000000034 method Methods 0.000 title description 3
- 238000002360 preparation method Methods 0.000 title description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- 150000001875 compounds Chemical group 0.000 claims description 6
- 239000013078 crystal Substances 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 230000002421 anti-septic effect Effects 0.000 claims description 2
- 238000000354 decomposition reaction Methods 0.000 claims description 2
- 239000002934 diuretic Substances 0.000 claims description 2
- 230000001882 diuretic effect Effects 0.000 claims description 2
- 150000007530 organic bases Chemical class 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 235000011121 sodium hydroxide Nutrition 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 3
- ABBZJHFBQXYTLU-UHFFFAOYSA-N but-3-enamide Chemical compound NC(=O)CC=C ABBZJHFBQXYTLU-UHFFFAOYSA-N 0.000 description 3
- BRMYZIKAHFEUFJ-UHFFFAOYSA-L mercury diacetate Chemical compound CC(=O)O[Hg]OC(C)=O BRMYZIKAHFEUFJ-UHFFFAOYSA-L 0.000 description 2
- WRYNUJYAXVDTCB-UHFFFAOYSA-M acetyloxymercury Chemical compound CC(=O)O[Hg] WRYNUJYAXVDTCB-UHFFFAOYSA-M 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 150000002731 mercury compounds Chemical class 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/10—Mercury compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Herstellung einer heterocyelischen Quecksilberverbindung. Es wurde gefunden, dass man zu einer neuen heterocyclischen Quecksilberverbindung gelangen kann, wenn man auf das Pyridin- 3-carbonsäure-2-carbonsäureallylamid Mer- curiacetat in Gegenwart von Methylalkohol einwirken lässt.
Die auf diese Weise gewonnene Verbin dung der Formel:
EMI0001.0007
bildet ein weisses Kristallpulver, das gegen Natronlauge beständig ist und einen Zer setzungspunkt von 14011 zeigt. Die neue Verbindung bildet mit Alkalien, organischen Basen und dergleichen wasserlösliche Salze.
Die neue Verbindung zeichnet sich durch ihre starke diuretische und antiseptische Wirkung bei guter Verträglichkeit aus. Sie soll therapeutische Verwendung finden. <I>Beispiel:</I> 2 Teile Pyridin-3-carbonsäure-2-carbon- säureallylamid werden in methylalkoholischer Lösung mit 3 Teilen Mercuriacetat umgesetzt. Die neue Quecksilberverbindung der in der Einleitung erwähnten Formel scheidet sich als Öl aus, das beim Reiben zu einem weissen Kristallpulver erstarrt.
PATENTANSPRUCH: Verfahren zur Herstellung einer hetero- cyclischen Quecksilberverbindung, dadurch gekennzeichnet, dass man auf das Pyridin-3- carbonsäure-2-carbonsäureallylamid Mercuri- acetat in Gegenwart von Methylalkohol ein wirken lässt.
Die auf diese Weise gewonnene Verbin dung der Formel:
Process for the preparation of a heterocyclic mercury compound. It has been found that a new heterocyclic mercury compound can be obtained if mercuriacetate is allowed to act on the pyridine-3-carboxylic acid-2-carboxylic acid allylamide in the presence of methyl alcohol.
The compound of the formula obtained in this way:
EMI0001.0007
forms a white crystal powder that is resistant to caustic soda and has a decomposition point of 14011. The new compound forms water-soluble salts with alkalis, organic bases and the like.
The new compound is characterized by its strong diuretic and antiseptic effect and good tolerance. It should find therapeutic use. <I> Example: </I> 2 parts of pyridine-3-carboxylic acid-2-carboxylic acid allylamide are reacted with 3 parts of mercuric acetate in a methyl alcoholic solution. The new mercury compound of the formula mentioned in the introduction separates itself as an oil, which solidifies to a white crystal powder when rubbed.
PATENT CLAIM: Process for the production of a heterocyclic mercury compound, characterized in that mercury acetate is allowed to act on the pyridine-3-carboxylic acid-2-carboxylic acid allylamide in the presence of methyl alcohol.
The compound of the formula obtained in this way:
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH183121T | 1935-11-11 | ||
| CH176757T | 1935-11-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH183121A true CH183121A (en) | 1936-03-15 |
Family
ID=25719882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH183121D CH183121A (en) | 1935-11-11 | 1935-11-11 | Process for the preparation of a heterocyclic mercury compound. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH183121A (en) |
-
1935
- 1935-11-11 CH CH183121D patent/CH183121A/en unknown
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