CH163448A - Process for obtaining a durable derivative of cyclohexenyl-ethyl-barbituric acid. - Google Patents
Process for obtaining a durable derivative of cyclohexenyl-ethyl-barbituric acid.Info
- Publication number
- CH163448A CH163448A CH163448DA CH163448A CH 163448 A CH163448 A CH 163448A CH 163448D A CH163448D A CH 163448DA CH 163448 A CH163448 A CH 163448A
- Authority
- CH
- Switzerland
- Prior art keywords
- ethyl
- cyclohexenyl
- barbituric acid
- obtaining
- durable
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Gewinnung eines haltbaren Derivates der Cyclohexenyl-äthyl- barbitursäure. Das Hauptpatent betrifft ein Verfahren zur Gewinnung eines haltbaren Salzes der Cyclohexenyl-äthyl-barbitursäure, welches da durch gekennzeichnet ist, dass man die Cyclo- hexeiiyl-äthyl-barbitursäure in Gegenwart von Alkali mit einer Caleiumverbindung in ihr Calciumsalz umwandelt, das gegen den Ein- fluss des Lichtes und des Luftsauerstoffes nicht mir sehr beständig,
sondern darüber hinaus auch eine schnellere Resorption zeigt.
Es wurde nun gefunden, dass man die Cyclohexenyl-äthyl-barbitursäureauchdadurch in ein haltbares Salz von ähnlichen Eigen schaften, umwandeln kann, wenn man sie in Gegenwart von Alkali durch Einwirkung einer Lithiumverbindung in das cyelohexenyl- äthyl-barbitLirsaure Lithium überführt.
Das Endprodukt stellt ein in Wasser schwerlösliches weisses Pulver dar, das man durch Zusatz von starken Säuren in die in Wasser ebenfalls schwerlösliche Cyclohexenyl- äthyl-barbitursäure, die nach dem Trocknen den Schmelzpunkt<B>172 0</B> zeigt, rückverwandeln kann.
<I>Beispiel:</I> Eine aus<B>25</B> Gewichtsteilen Cyclohexenyl- äthyl-barbitursäure und<B>106</B> Gewichtsteilen n-Natronlauge bei<B>30 0</B> hergestellte Lösung wird mit einer Lösung von<B>8,3</B> Gewichts teilen Lithiuinehlorid (2 aq) in 20 Gewichts teilen Wasser versetzt und das nach längerem Stehen ausgeschiedene Lithiumsalz der Cyclo- hexenyl-äthyl-bai,bitursäure gewaschen und im Vakuum getroknet.
Process for obtaining a durable derivative of cyclohexenyl-ethyl-barbituric acid. The main patent relates to a process for obtaining a stable salt of cyclohexenyl-ethyl-barbituric acid, which is characterized in that the cyclohexenyl-ethyl-barbituric acid is converted in the presence of alkali with a calcium compound into its calcium salt, which is flow of light and oxygen from the air not very steady for me,
but also shows faster absorption.
It has now been found that the cyclohexenyl-ethyl-barbituric acid can also be converted into a durable salt of similar properties if it is converted into the cyelohexenyl-ethyl-barbituric acid lithium in the presence of alkali by the action of a lithium compound.
The end product is a white powder which is sparingly soluble in water and which can be converted back into cyclohexenylethylbarbituric acid, which is also sparingly soluble in water and which has a melting point of 172 ° after drying, by adding strong acids.
<I> Example: </I> A solution prepared from <B> 25 </B> parts by weight of cyclohexenylethylbarbituric acid and <B> 106 </B> parts by weight of n-sodium hydroxide solution at <B> 30 0 </B> a solution of 8.3 parts by weight of lithium chloride (2 aq) in 20 parts by weight of water is added, and the lithium salt of cyclohexenylethylbita, bituric acid which separates out after prolonged standing is washed and dried in vacuo .
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE163448X | 1931-05-21 | ||
CH161692T | 1932-05-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH163448A true CH163448A (en) | 1933-08-15 |
Family
ID=25717463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH163448D CH163448A (en) | 1931-05-21 | 1932-05-12 | Process for obtaining a durable derivative of cyclohexenyl-ethyl-barbituric acid. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH163448A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2501551A (en) * | 1950-03-21 | S-cycloheptenyl-s-ethyl barbituric |
-
1932
- 1932-05-12 CH CH163448D patent/CH163448A/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2501551A (en) * | 1950-03-21 | S-cycloheptenyl-s-ethyl barbituric |
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