CH253643A - Process for the preparation of 2- (3 ', 5'-dichloro-salicoylamino) -thiazole. - Google Patents

Process for the preparation of 2- (3 ', 5'-dichloro-salicoylamino) -thiazole.

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Publication number
CH253643A
CH253643A CH253643DA CH253643A CH 253643 A CH253643 A CH 253643A CH 253643D A CH253643D A CH 253643DA CH 253643 A CH253643 A CH 253643A
Authority
CH
Switzerland
Prior art keywords
thiazole
dichloro
salicoylamino
preparation
amino
Prior art date
Application number
Other languages
German (de)
Inventor
Ag Sandoz
Original Assignee
Ag Sandoz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag Sandoz filed Critical Ag Sandoz
Publication of CH253643A publication Critical patent/CH253643A/en

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  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Description

  

  Verfahren zur Herstellung von     2-(3',5'-Dichlor-salicoylamino)-thiazol.       Das vorliegende Patent betrifft ein     Ver-          fJhren    zur     Herstellung    von     2-(3',5'-Dichlor-          .@llicoy        lamino)-thiazol,    welches dadurch ge  kennzeichnet ist, dass man     3,5-Dichlor-sali-          cvlsäurechloi-id    auf     2-Amino-thiazol    einwir  ken lässt.  



  <I>Beispiel:</I>  <B>10-</B>     2-Amino-thiazol    werden in einer     Mi-          chiing    von 40     em@    Äther und 10     cm3        Pyridin          gelöst.    In     dieser    Lösung     gibt    man tropfen  wcie eine     3lischung    von 19     g        3,5-Dichlor-          salicyl@äiircchlorid,    gelöst. in 115 cm'     Chloro-          forni.    innerhalb 20     iVlinuten    zu.

   Die Reak  tionsmischung wird     darauf    während 4 Stun  den am     Rückfluss    zum Sieden erhitzt. Ein  Teil des     Lösungsmittels    wird     unter    vermin  dertem Druck     a.bdestilliert,    worauf das Re  aktionsprodukt auskristallisiert.

   Nach der  Isolierung wird das Reaktionsprodukt     wie-          ilerholt    aus Alkohol umkristallisiert und     ge-          troeknet.        Smp.    275  C     (korr.).       Die Verbindung besitzt die Formel  
EMI0001.0038     
    Analyse:       Bruttozusammensetzung        CIo'        o02N2SC12.          Ber.        C41,5%;    H2,1%; N9,7%.  



       Gef.   <B>C41,75%;</B> 112,34%;<B>N9,64%.</B>    Das     2-(3',5'-Dichlor-salicoylamino)-thiazol     soll als     F'ungicid    Verwendung finden.



  Process for the preparation of 2- (3 ', 5'-dichloro-salicoylamino) -thiazole. The present patent relates to a process for the preparation of 2- (3 ', 5'-dichloro-. @ Llicoy lamino) -thiazole, which is characterized in that one has 3,5-dichloro-salicylic acid chloride 2-Amino-thiazole can act.



  <I> Example: </I> <B> 10- </B> 2-amino-thiazole are dissolved in a mixture of 40 em @ ether and 10 cm3 pyridine. A mixture of 19 g of 3,5-dichlorosalicylic chloride is added dropwise to this solution. in 115 cm 'chloroforni. within 20 minutes.

   The reaction mixture is then heated to boiling under reflux for 4 hours. Some of the solvent is distilled off under reduced pressure, whereupon the reaction product crystallizes out.

   After isolation, the reaction product is repeatedly recrystallized from alcohol and dried. M.p. 275 C (corr.). The compound has the formula
EMI0001.0038
    Analysis: gross composition CIo 'o02N2SC12. Ber. C41.5%; H2.1%; N9.7%.



       Found. <B> C41.75%; </B> 112.34%; <B> N9.64%. </B> The 2- (3 ', 5'-dichloro-salicoylamino) -thiazole is said to be F 'ungicid use.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von 2-(3',5' Dichlor-salicoylamino)-thiazol, dadurch ge kennzeichnet, da,ss man 3,5-Dichlor-salicyl- säurechlorid auf 2-Amino-thiazol einwirken lässt. Die neue Verbindung von der Formel EMI0001.0053 besitzt den Smp. 275 C (korr.). Analyse: Bruttozusammensetzung C1oHo02N2SC12. Ber. C41,5%; H2,1%; N9,7%. PATENT CLAIM: Process for the preparation of 2- (3 ', 5' dichloro-salicoylamino) -thiazole, characterized in that 3,5-dichloro-salicylic acid chloride is allowed to act on 2-amino-thiazole. The new compound of the formula EMI0001.0053 has the melting point 275 C (corr.). Analysis: gross composition C1oHo02N2SC12. Ber. C41.5%; H2.1%; N9.7%. Gef. C 41,75 % ; 112,34%; N 9,64/05'. Das 2-(3',5'-Dichlor-salicoylamino)-thiazol soll als Fungicid Verwendung finden. Found C 41.75%; 112.34%; N 9.64 / 05 '. The 2- (3 ', 5'-dichloro-salicoylamino) -thiazole is said to be used as a fungicide.
CH253643D 1945-12-07 1945-12-07 Process for the preparation of 2- (3 ', 5'-dichloro-salicoylamino) -thiazole. CH253643A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH253643T 1945-12-07
CH246984T 1945-12-07

Publications (1)

Publication Number Publication Date
CH253643A true CH253643A (en) 1948-03-15

Family

ID=25729152

Family Applications (1)

Application Number Title Priority Date Filing Date
CH253643D CH253643A (en) 1945-12-07 1945-12-07 Process for the preparation of 2- (3 ', 5'-dichloro-salicoylamino) -thiazole.

Country Status (1)

Country Link
CH (1) CH253643A (en)

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