CH0642525H1 - Chemical compounds. - Google Patents

Chemical compounds.

Info

Publication number
CH0642525H1
CH0642525H1 CH92922008.5T CH92922008T CH0642525H1 CH 0642525 H1 CH0642525 H1 CH 0642525H1 CH 92922008 T CH92922008 T CH 92922008T CH 0642525 H1 CH0642525 H1 CH 0642525H1
Authority
CH
Switzerland
Prior art keywords
acid
nucleosides
fatty acid
ara
esters
Prior art date
Application number
CH92922008.5T
Other languages
English (en)
Inventor
Are Dalen
Finn Myren
Bernt Brretzen
Kjell Stokke
Original Assignee
Norsk Hydro A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norsk Hydro A/S filed Critical Norsk Hydro A/S
Publication of CH0642525H1 publication Critical patent/CH0642525H1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
CH92922008.5T 1991-10-07 1992-09-30 Chemical compounds. CH0642525H1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9121257A GB2260319B (en) 1991-10-07 1991-10-07 Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
PCT/NO1992/000162 WO1993007163A1 (en) 1991-10-07 1992-09-30 Chemical compounds

Publications (1)

Publication Number Publication Date
CH0642525H1 true CH0642525H1 (en) 1999-06-30

Family

ID=10702531

Family Applications (1)

Application Number Title Priority Date Filing Date
CH92922008.5T CH0642525H1 (en) 1991-10-07 1992-09-30 Chemical compounds.

Country Status (27)

Country Link
US (1) US6548486B1 (no)
EP (1) EP0642525B1 (no)
JP (1) JP2873313B2 (no)
KR (1) KR100272732B1 (no)
AT (1) ATE152454T1 (no)
CA (1) CA2120725C (no)
CH (1) CH0642525H1 (no)
CZ (1) CZ288153B6 (no)
DE (1) DE69219482T2 (no)
DK (1) DK0642525T3 (no)
FI (2) FI105035B (no)
GB (1) GB2260319B (no)
GR (1) GR3024149T3 (no)
HK (1) HK1007430A1 (no)
HU (1) HU219400B (no)
IL (1) IL103351A (no)
MX (1) MX9205715A (no)
NO (1) NO300014B1 (no)
NZ (1) NZ244535A (no)
PL (1) PL170846B1 (no)
RU (1) RU2126417C1 (no)
SG (1) SG47759A1 (no)
SK (1) SK281903B6 (no)
TW (1) TW347333B (no)
UA (1) UA41296C2 (no)
WO (1) WO1993007163A1 (no)
ZA (1) ZA927432B (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9307043D0 (en) * 1993-04-05 1993-05-26 Norsk Hydro As Chemical compounds
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
GB2321455A (en) * 1997-01-24 1998-07-29 Norsk Hydro As Lipophilic derivatives of biologically active compounds
GB0201179D0 (en) * 2002-01-18 2002-03-06 Angeletti P Ist Richerche Bio Therapeutic agents
TWI332507B (en) 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
US9029345B2 (en) * 2005-03-16 2015-05-12 Case Western Reserve University Selective inhibitors of translesion DNA replication
US8114847B2 (en) 2005-03-16 2012-02-14 Case Western Reserve University Selective inhibitors of translesion DNA replication
NO324263B1 (no) * 2005-12-08 2007-09-17 Clavis Pharma Asa Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser
US8497292B2 (en) * 2005-12-28 2013-07-30 Translational Therapeutics, Inc. Translational dysfunction based therapeutics
WO2008150438A1 (en) * 2007-06-01 2008-12-11 Luitpold Pharmaceuticals, Inc. Pmea lipid conjugates
US9296776B2 (en) 2007-07-09 2016-03-29 Eastern Virginia Medical School Substituted nucleoside derivatives with antiviral and antimicrobial properties
EP2205073A4 (en) * 2007-09-26 2013-03-06 Sinai School Medicine AZACYTIDINE ANALOGS AND USES THEREOF
WO2013033705A2 (en) 2011-09-01 2013-03-07 Case Western Reserve University Non-natural nucleosides as theranostic agents
US9493500B2 (en) 2012-07-19 2016-11-15 Richard Daifuku Fluorinated pyrimidine analogs and methods of use thereof
US9821173B2 (en) 2013-02-08 2017-11-21 Case Western Reserve University Anti-cancer agents and methods of use
RU2621145C2 (ru) * 2015-11-03 2017-05-31 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежский государственный университет" (ФГБОУ ВПО "ВГУ") Способ получения липосом
US20200407393A1 (en) * 2018-03-07 2020-12-31 Glaxosmithkline Intellectual Property (No. 2) Limited Medical Use

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1325797A (en) * 1970-09-24 1973-08-08 Upjohn Co Medicines comprising cytidine derivatives
US3920630A (en) * 1970-09-24 1975-11-18 Upjohn Co 2,2{40 -Anhydro-ara-cytidine compounds and process of preparation
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
DE3100478A1 (de) * 1981-01-09 1982-08-12 Dr. Thilo & Co GmbH, 8021 Sauerlach 5'ester von pyrimidinnucleosiden mit antiviraler wirksamkeit, verfahren zur herstellung und daraus hergestellte arzneimittel
US4355032B2 (en) 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4816447A (en) 1981-08-26 1989-03-28 Merck & Co., Inc. Anti-viral guanine compounds
NZ201662A (en) 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4556659A (en) * 1982-08-09 1985-12-03 Syntex (U.S.A.) Inc. Substituted 9-(1-0- or 3-0-monosubstituted or 1,3-Di-0-substituted propoxymethyl)-purines as antiviral agents
JPH0655755B2 (ja) * 1985-01-23 1994-07-27 富山化学工業株式会社 新規な５−フルオロ−２′−デオキシウリジン−３′−ホスフエ−ト誘導体およびその塩
US4684631A (en) 1984-10-09 1987-08-04 Toyama Chemical Co., Ltd. Novel 5-fluoro-2-deoxyuridine derivatives and salts thereof, process for producing the same, and antitumor agents containing the same
US5223263A (en) * 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
JPS6483092A (en) * 1987-09-24 1989-03-28 Arakawa Chotaro & Co Novel n6,n6-dimethyladenosine derivative having carcinostatic activity, its production and carcinostatic agent containing said derivative as active component
KR890701609A (ko) * 1987-10-28 1989-12-21 원본미기재 아실 데옥시리보뉴클레오시드 유도체 및 그의 사용
JPH0278696A (ja) * 1988-09-13 1990-03-19 Shoichiro Ozaki ５−フルオロウラシル誘導体
IE980216A1 (en) * 1989-04-17 2000-02-23 Scotia Holdings Plc Anti-virals
FI105556B (fi) * 1991-09-30 2000-09-15 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten pyrimidiiniukleosidijohdannaisten valmistamiseksi, joilla on kasvaimen vastaista vaikutusta

Also Published As

Publication number Publication date
GR3024149T3 (en) 1997-10-31
GB9121257D0 (en) 1991-11-20
DE69219482D1 (de) 1997-06-05
EP0642525B1 (en) 1997-05-02
CZ80594A3 (en) 1994-12-15
MX9205715A (es) 1993-05-01
NZ244535A (en) 1995-08-28
TW347333B (en) 1998-12-11
DK0642525T3 (da) 1997-11-03
CA2120725A1 (en) 1993-04-15
WO1993007163A1 (en) 1993-04-15
NO941269L (no) 1994-04-07
JP2873313B2 (ja) 1999-03-24
FI941574A (fi) 1994-04-06
SK281903B6 (sk) 2001-09-11
HUT68008A (en) 1995-05-29
SK39794A3 (en) 1994-10-05
PL170846B1 (en) 1997-01-31
NO941269D0 (no) 1994-04-07
HU219400B (hu) 2001-04-28
FI990270A0 (fi) 1999-02-10
HK1007430A1 (en) 1999-04-09
KR100272732B1 (ko) 2000-11-15
NO300014B1 (no) 1997-03-17
FI105035B (fi) 2000-05-31
FI990270A (fi) 1999-02-10
GB2260319A (en) 1993-04-14
CZ288153B6 (en) 2001-05-16
IL103351A (en) 2000-02-17
HU9400988D0 (en) 1994-07-28
ZA927432B (en) 1993-06-09
US6548486B1 (en) 2003-04-15
CA2120725C (en) 2000-04-11
FI941574A0 (fi) 1994-04-06
GB2260319B (en) 1995-12-06
UA41296C2 (uk) 2001-09-17
AU672369B2 (en) 1996-10-03
JPH06511249A (ja) 1994-12-15
AU2867392A (en) 1993-05-03
IL103351A0 (en) 1993-03-15
SG47759A1 (en) 1998-04-17
ATE152454T1 (de) 1997-05-15
EP0642525A1 (en) 1995-03-15
DE69219482T2 (de) 1997-10-23
RU2126417C1 (ru) 1999-02-20

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