CA990292A - Imidazo-triazinones - Google Patents

Imidazo-triazinones

Info

Publication number
CA990292A
CA990292A CA155,720A CA155720A CA990292A CA 990292 A CA990292 A CA 990292A CA 155720 A CA155720 A CA 155720A CA 990292 A CA990292 A CA 990292A
Authority
CA
Canada
Prior art keywords
triazinones
imidazo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA155,720A
Other languages
English (en)
Other versions
CA155720S (en
Inventor
David Hartley
Susan C. Garside
Lawrence H.C. Lunts
Alexander W. Oxford
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allen and Hanburys Ltd
Original Assignee
Allen and Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allen and Hanburys Ltd filed Critical Allen and Hanburys Ltd
Application granted granted Critical
Publication of CA990292A publication Critical patent/CA990292A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA155,720A 1971-11-19 1972-11-01 Imidazo-triazinones Expired CA990292A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5375071A GB1400999A (en) 1971-11-19 1971-11-19 Imidazo-triazine compounds and their use in therapeutic compositions

Publications (1)

Publication Number Publication Date
CA990292A true CA990292A (en) 1976-06-01

Family

ID=10468856

Family Applications (1)

Application Number Title Priority Date Filing Date
CA155,720A Expired CA990292A (en) 1971-11-19 1972-11-01 Imidazo-triazinones

Country Status (18)

Country Link
US (1) US3840537A (cs)
JP (1) JPS563873B2 (cs)
AT (1) AT321923B (cs)
AU (1) AU472127B2 (cs)
BE (1) BE791025A (cs)
CA (1) CA990292A (cs)
CH (1) CH594671A5 (cs)
DE (1) DE2255172A1 (cs)
DK (1) DK138691B (cs)
ES (1) ES408736A1 (cs)
FR (1) FR2160407B1 (cs)
GB (1) GB1400999A (cs)
IE (1) IE37046B1 (cs)
IL (1) IL40686A (cs)
NL (1) NL7215646A (cs)
PH (1) PH9669A (cs)
SE (1) SE402915B (cs)
ZA (1) ZA727532B (cs)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1457873A (en) * 1973-01-04 1976-12-08 Allen & Hanburys Ltd Imidazotriazines
DE2314488C3 (de) * 1973-03-23 1979-01-04 C.H. Boehringer Sohn, 6507 Ingelheim 8-(2,6-Dichlorphenyl)-7-(4-chlorphenyl)-5-oxo-233,8-tetrahydro-imidazo [1,2-a] -s-triazin, Verfahren zu dessen Herstellung und dieses enthaltene Arzneimittel
DE2335193A1 (de) * 1973-07-11 1975-01-30 Hoechst Ag Bis-triazinobenzimidazole und ihre herstellung
US4107307A (en) * 1977-02-03 1978-08-15 American Cyanamid Company Imidazo [1,5-d]-as-triazine-4(3H)-ones and thiones
USRE30511E (en) * 1977-02-03 1981-02-10 American Cyanamid Company Imidazo[1,5-d]-as-triazine-4(3H)-ones and thiones
US4115572A (en) * 1977-02-03 1978-09-19 American Cyanamid Company Imidazo-[1,5-d]-as-triazin-1(2H)-ones and method of ameliorating asthma
DK109578A (da) * 1977-03-25 1978-09-26 Allen & Hanburys Ltd Fremgangsmaade til fremstilling af heterocycliske forbindelser
US4107308A (en) * 1977-10-18 1978-08-15 American Cyanamid Company Imidazo[1,5-d]-as-triazines
US4308384A (en) * 1978-09-18 1981-12-29 Glaxo Group Limited Production of triazinones
HU187474B (en) * 1981-11-18 1986-01-28 Gyogyszerkutato Intezet,Hu Process for producing new spiro-pyrazole-square bracket-1,5-d-square bracket closed-square bracket-1,2,4-square bracket closed-triazine derivatives
US4395547A (en) * 1982-02-10 1983-07-26 American Cyanamid Co. Process for preparing 1-substituted-6-n-propyl-8-methylimidazo[1,5-d]-as-triazin-4(3H)-ones
AU622330B2 (en) * 1989-06-23 1992-04-02 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
US6624181B1 (en) * 1997-02-28 2003-09-23 Altana Pharma Ag Synergistic combination
SK287161B6 (sk) * 1997-11-12 2010-02-08 Bayer Healthcare Ag 2-Fenylsubstituované imidazotriazinóny, spôsob ich výroby, liečivá obsahujúce tieto látky a ich použitie
DE19827640A1 (de) * 1998-06-20 1999-12-23 Bayer Ag 7-Alkyl- und Cycloalkyl-substituierte Imidazotriazinone
US6288118B1 (en) 1998-08-26 2001-09-11 Smithkline Beecham Corporation Therapies for treating pulmonary diseases
TR200201317T2 (tr) * 1999-08-21 2002-11-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Sinerjistik kombinasyon.
BR0209541A (pt) * 2001-05-09 2004-04-20 Bayer Healthcare Ag Uso das imidazotriazinonas 2-fenil-substituìdas
GB0113344D0 (en) 2001-06-01 2001-07-25 Bayer Ag Novel heterocycles 3
GB0113343D0 (en) * 2001-06-01 2001-07-25 Bayer Ag Novel Heterocycles 2
DE10135815A1 (de) 2001-07-23 2003-02-06 Bayer Ag Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen
DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
WO2004087652A2 (en) * 2003-04-01 2004-10-14 Smithkline Beecham Corporation Imidazotriazine compounds
EP2308879A1 (en) 2004-04-02 2011-04-13 OSI Pharmaceuticals, Inc. 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors
DE102005001989A1 (de) * 2005-01-15 2006-07-20 Bayer Healthcare Ag Intravenöse Formulierungen von PDE-Inhibitoren
DE102005009241A1 (de) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit kontrollierter Bioverfügbarkeit
DE102005009240A1 (de) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
AU2006299232A1 (en) * 2005-09-29 2007-04-12 Bayer Schering Pharma Aktiengesellschaft PDE inhibitors and combinations thereof for the treatment of urological disorders
KR20080078668A (ko) * 2005-11-17 2008-08-27 오에스아이 파마슈티컬스, 인코포레이티드 융합된 바이사이클릭 ｍＴＯＲ 억제자
WO2008151734A1 (en) * 2007-06-13 2008-12-18 Bayer Schering Pharma Aktiengesellschaft Pde inhibitors for the treatment of hearing impairment
CN102405214A (zh) 2009-04-20 2012-04-04 Osi药物有限责任公司 C-吡嗪-甲胺的制备
CN103374002B (zh) * 2012-04-19 2015-07-15 山东轩竹医药科技有限公司 磷酸二酯酶-5抑制剂
WO2016147659A1 (en) * 2015-03-16 2016-09-22 Sumitomo Dainippon Pharma Co., Ltd. Bicyclic imidazolo derivative
WO2017000276A1 (en) * 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Bicyclic heterocyclic compounds as pde2 inhibitors
WO2017204316A1 (ja) * 2016-05-27 2017-11-30 塩野義製薬株式会社 ５－オキソ－１，２，４－トリアジン誘導体およびその医薬組成物

Also Published As

Publication number Publication date
CH594671A5 (cs) 1978-01-13
FR2160407B1 (cs) 1975-10-17
DK138691C (cs) 1979-03-26
BE791025A (fr) 1973-05-07
IE37046B1 (en) 1977-04-27
JPS563873B2 (cs) 1981-01-27
FR2160407A1 (cs) 1973-06-29
NL7215646A (cs) 1973-05-22
AU4819172A (en) 1974-05-16
GB1400999A (en) 1975-07-16
IL40686A (en) 1975-12-31
PH9669A (en) 1976-02-10
IL40686A0 (en) 1972-12-29
JPS4857993A (cs) 1973-08-14
IE37046L (en) 1973-05-19
ZA727532B (en) 1973-07-25
DK138691B (da) 1978-10-16
AT321923B (de) 1975-04-25
SE402915B (sv) 1978-07-24
US3840537A (en) 1974-10-08
AU472127B2 (en) 1976-05-20
DE2255172A1 (de) 1973-05-24
ES408736A1 (es) 1976-03-01

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