CA3278705A1 - Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles - Google Patents

Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles

Info

Publication number
CA3278705A1
CA3278705A1 CA3278705A CA3278705A CA3278705A1 CA 3278705 A1 CA3278705 A1 CA 3278705A1 CA 3278705 A CA3278705 A CA 3278705A CA 3278705 A CA3278705 A CA 3278705A CA 3278705 A1 CA3278705 A1 CA 3278705A1
Authority
CA
Canada
Prior art keywords
reproducible
consistent
containing molecules
molecules exhibiting
predictable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3278705A
Other languages
English (en)
Inventor
Zhimei DU
Pranhitha Reddy
Randal B. Bass
Feng He
Iii Fanslow William C.
Yuling Zhang
Da REN
Randal R. Ketchem
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CA3278705A1 publication Critical patent/CA3278705A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
CA3278705A 2013-09-05 2014-09-05 Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles Pending CA3278705A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361874222P 2013-09-05 2013-09-05
US61/874,222 2013-09-05
CA2923145A CA2923145C (en) 2013-09-05 2014-09-05 MOLECULES CONTAINING FCS AND EXHIBITING PREDICTABLE, UNIFORM AND REPRODUCIBLE GLYCOFORM PROFILES

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2923145A Division CA2923145C (en) 2013-09-05 2014-09-05 MOLECULES CONTAINING FCS AND EXHIBITING PREDICTABLE, UNIFORM AND REPRODUCIBLE GLYCOFORM PROFILES

Publications (1)

Publication Number Publication Date
CA3278705A1 true CA3278705A1 (en) 2026-03-02

Family

ID=52628971

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3278705A Pending CA3278705A1 (en) 2013-09-05 2014-09-05 Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles
CA2923145A Active CA2923145C (en) 2013-09-05 2014-09-05 MOLECULES CONTAINING FCS AND EXHIBITING PREDICTABLE, UNIFORM AND REPRODUCIBLE GLYCOFORM PROFILES

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2923145A Active CA2923145C (en) 2013-09-05 2014-09-05 MOLECULES CONTAINING FCS AND EXHIBITING PREDICTABLE, UNIFORM AND REPRODUCIBLE GLYCOFORM PROFILES

Country Status (7)

Country Link
US (2) US11427627B2 (enExample)
EP (2) EP3712166A1 (enExample)
JP (1) JP6668241B2 (enExample)
AU (1) AU2014318017B2 (enExample)
CA (2) CA3278705A1 (enExample)
MX (1) MX2016002870A (enExample)
WO (1) WO2015035215A1 (enExample)

Families Citing this family (8)

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AU2011258425B2 (en) * 2010-05-27 2015-12-10 Merck Sharp & Dohme Llc Method for preparing antibodies having improved properties
ES2683347T3 (es) 2011-02-11 2018-09-26 Merck Patent Gmbh Anticuerpo anti-integrina alfa-v para el tratamiento de cáncer de próstata
EP3712166A1 (en) 2013-09-05 2020-09-23 Amgen Inc. Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles
MA41459A (fr) * 2015-02-03 2017-12-12 Als Therapy Development Inst Anticorps anti-cd40l et méthodes pour traiter des maladies ou des troubles liés aux cd40l
US12024560B2 (en) * 2017-03-28 2024-07-02 Lyvgen Biopharma Holdings Limited Therapeutic agents and methods for enhancing immune responses in tumor microenvironment
IL307155B2 (en) * 2018-05-01 2025-11-01 Amgen Inc Antibodies with modulated glycan profiles
JP7621263B2 (ja) * 2019-02-22 2025-01-24 武▲漢▼友芝友生物制▲薬▼股▲ふん▼有限公司 改変されたＦｃ断片、それを含む抗体、及びそれらの使用
AR133427A1 (es) 2023-07-31 2025-09-24 Sanofi Sa Anticuerpos anti-gprc5d y composiciones

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AU2014318017A1 (en) 2016-03-24
WO2015035215A1 (en) 2015-03-12
US20230235024A1 (en) 2023-07-27
EP3712166A1 (en) 2020-09-23
JP6668241B2 (ja) 2020-03-18
EP3041863A1 (en) 2016-07-13
JP2016531581A (ja) 2016-10-13
CA2923145A1 (en) 2015-03-12
US20160207980A1 (en) 2016-07-21
US12643938B2 (en) 2026-06-02
AU2014318017B2 (en) 2020-02-06
US11427627B2 (en) 2022-08-30
CA2923145C (en) 2025-09-16
EP3041863A4 (en) 2017-08-16

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