CA3206960A1 - Synthetic polynucleotides and methods for selectively amplifying alleles - Google Patents
Synthetic polynucleotides and methods for selectively amplifying alleles Download PDFInfo
- Publication number
- CA3206960A1 CA3206960A1 CA3206960A CA3206960A CA3206960A1 CA 3206960 A1 CA3206960 A1 CA 3206960A1 CA 3206960 A CA3206960 A CA 3206960A CA 3206960 A CA3206960 A CA 3206960A CA 3206960 A1 CA3206960 A1 CA 3206960A1
- Authority
- CA
- Canada
- Prior art keywords
- selector
- polynucleotide
- optionally
- residue
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163144723P | 2021-02-02 | 2021-02-02 | |
| US63/144,723 | 2021-02-02 | ||
| PCT/US2022/014908 WO2022169846A1 (en) | 2021-02-02 | 2022-02-02 | Synthetic polynucleotides and methods for selectively amplifying alleles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3206960A1 true CA3206960A1 (en) | 2022-08-11 |
Family
ID=82741675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3206960A Pending CA3206960A1 (en) | 2021-02-02 | 2022-02-02 | Synthetic polynucleotides and methods for selectively amplifying alleles |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20240301481A1 (https=) |
| EP (1) | EP4288557A4 (https=) |
| JP (1) | JP2024505119A (https=) |
| KR (1) | KR20230141826A (https=) |
| CN (1) | CN116888271A (https=) |
| AU (1) | AU2022216246A1 (https=) |
| CA (1) | CA3206960A1 (https=) |
| WO (1) | WO2022169846A1 (https=) |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2222510A1 (en) * | 1995-06-07 | 1996-12-19 | Gen-Probe Incorporated | Template and primer based synthesis of enzymatically cleavable oligonucleotides |
| US5916777A (en) * | 1995-06-07 | 1999-06-29 | Gen-Probe Incorporated | Enzymatic synthesis of oligonucleotides using 3'-ribonucleotide primers |
| CN1254548C (zh) * | 2000-08-23 | 2006-05-03 | 宝生物工程株式会社 | 核酸扩增方法 |
| WO2002064833A1 (en) * | 2001-02-15 | 2002-08-22 | Takara Bio Inc. | Method of detecting nucleotide polymorphism |
| US10227641B2 (en) * | 2008-04-30 | 2019-03-12 | Integrated Dna Technologies, Inc. | RNase H-based assays utilizing modified RNA monomers |
| ES2384681T3 (es) * | 2008-08-12 | 2012-07-10 | F. Hoffmann-La Roche Ag | Extensión de cebadores correctora |
| WO2011085075A2 (en) * | 2010-01-07 | 2011-07-14 | Gen9, Inc. | Assembly of high fidelity polynucleotides |
| CA2863808C (en) * | 2012-02-20 | 2020-07-21 | Speedx Pty Ltd | Methods and oligonucleotides for amplifying and/or detecting nucleic acids |
| UA116205C2 (uk) * | 2012-04-09 | 2018-02-26 | Енвіролоджикс Інк. | Спосіб кількісного визначення послідовності нуклеїнової кислоти в зразку |
| WO2017142989A1 (en) * | 2016-02-17 | 2017-08-24 | Admera Health LLC | Nucleic acid preparation and analysis |
-
2022
- 2022-02-02 AU AU2022216246A patent/AU2022216246A1/en active Pending
- 2022-02-02 EP EP22750306.7A patent/EP4288557A4/en active Pending
- 2022-02-02 KR KR1020237029568A patent/KR20230141826A/ko active Pending
- 2022-02-02 WO PCT/US2022/014908 patent/WO2022169846A1/en not_active Ceased
- 2022-02-02 US US18/274,453 patent/US20240301481A1/en active Pending
- 2022-02-02 JP JP2023571247A patent/JP2024505119A/ja active Pending
- 2022-02-02 CA CA3206960A patent/CA3206960A1/en active Pending
- 2022-02-02 CN CN202280012877.5A patent/CN116888271A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4288557A4 (en) | 2024-12-25 |
| EP4288557A1 (en) | 2023-12-13 |
| WO2022169846A1 (en) | 2022-08-11 |
| AU2022216246A1 (en) | 2023-09-14 |
| KR20230141826A (ko) | 2023-10-10 |
| JP2024505119A (ja) | 2024-02-02 |
| US20240301481A1 (en) | 2024-09-12 |
| CN116888271A (zh) | 2023-10-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12516372B2 (en) | Compositions and methods for screening mutations in thyroid cancer | |
| JP7467118B2 (ja) | 核酸分子を同定するための組成物と方法 | |
| JP6744917B2 (ja) | バリアント検出のための方法 | |
| JP3561523B2 (ja) | 核酸分子を特性化する方法 | |
| US8460866B2 (en) | High throughput sequence-based detection of SNPs using ligation assays | |
| JP2020508083A (ja) | 標的ヌクレオチド配列の富化及び決定方法 | |
| CN101641452A (zh) | 限制性核酸内切酶增强的多态序列检测 | |
| JP6914831B2 (ja) | 標的核酸の高感度検出方法 | |
| KR20160117419A (ko) | Dna의 에러-프리 염기서열 분석 | |
| WO2019062614A1 (en) | METHOD FOR AMPLIFYING TARGET NUCLEIC ACID | |
| EP2982762A1 (en) | Nucleic acid amplification method using allele-specific reactive primer | |
| TR201806959T4 (tr) | Yabanıl tip ve/veya mutasyona uğramış bir hedef dna dizisini tespit etmeye yönelik yöntem ve kit. | |
| US20240301481A1 (en) | Synthetic polynucleotides and methods for selectively amplifying alleles | |
| US11174511B2 (en) | Methods and compositions for selecting and amplifying DNA targets in a single reaction mixture | |
| US20230374574A1 (en) | Compositions and methods for highly sensitive detection of target sequences in multiplex reactions | |
| CN111989408A (zh) | 检测靶核酸区域内的与参考序列的差异的方法 | |
| EP4022092A1 (en) | Compositions and methods for oncology precision assays | |
| US20250109446A1 (en) | Compositions and methods for oncology assays | |
| CN114891880A (zh) | 一种用于str连锁分析的引物组合物、检测方法和应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 3RD ANNIV.) - STANDARD Year of fee payment: 3 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250124 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT Effective date: 20250124 Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250124 |
|
| D11 | Substantive examination requested |
Free format text: ST27 STATUS EVENT CODE: A-1-1-D10-D11-D117 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: REQUEST FOR EXAMINATION RECEIVED Effective date: 20260131 |
|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 4TH ANNIV.) - STANDARD Year of fee payment: 4 |
|
| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P11-P101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT RECEIVED - VOLUNTARY AMENDMENT Effective date: 20260131 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20260131 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20260131 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT Effective date: 20260131 |
|
| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT Effective date: 20260212 |
|
| P13 | Application amended |
Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED Effective date: 20260212 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT Effective date: 20260212 |
|
| D00 | Search and/or examination requested or commenced |
Free format text: ST27 STATUS EVENT CODE: A-1-1-D10-D00-D118 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: REQUEST FOR EXAMINATION REQUIREMENTS DETERMINED COMPLIANT Effective date: 20260302 |
|
| D11 | Substantive examination requested |
Free format text: ST27 STATUS EVENT CODE: A-1-2-D10-D11-D155 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: ALL REQUIREMENTS FOR EXAMINATION DETERMINED COMPLIANT Effective date: 20260302 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20260302 |