KR20230141826A - 합성 폴리뉴클레오티드 및 대립유전자를 선택적으로 증폭하기 위한 방법 - Google Patents

합성 폴리뉴클레오티드 및 대립유전자를 선택적으로 증폭하기 위한 방법 Download PDF

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Publication number
KR20230141826A
KR20230141826A KR1020237029568A KR20237029568A KR20230141826A KR 20230141826 A KR20230141826 A KR 20230141826A KR 1020237029568 A KR1020237029568 A KR 1020237029568A KR 20237029568 A KR20237029568 A KR 20237029568A KR 20230141826 A KR20230141826 A KR 20230141826A
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KR
South Korea
Prior art keywords
selector
polynucleotide
optionally
residue
dna
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Pending
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KR1020237029568A
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English (en)
Korean (ko)
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찰스 로디
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로디엑스, 인코포레이티드
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Publication of KR20230141826A publication Critical patent/KR20230141826A/ko
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • C12P19/28N-glycosides
    • C12P19/30Nucleotides
    • C12P19/34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6858Allele-specific amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6853Nucleic acid amplification reactions using modified primers or templates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
KR1020237029568A 2021-02-02 2022-02-02 합성 폴리뉴클레오티드 및 대립유전자를 선택적으로 증폭하기 위한 방법 Pending KR20230141826A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163144723P 2021-02-02 2021-02-02
US63/144,723 2021-02-02
PCT/US2022/014908 WO2022169846A1 (en) 2021-02-02 2022-02-02 Synthetic polynucleotides and methods for selectively amplifying alleles

Publications (1)

Publication Number Publication Date
KR20230141826A true KR20230141826A (ko) 2023-10-10

Family

ID=82741675

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237029568A Pending KR20230141826A (ko) 2021-02-02 2022-02-02 합성 폴리뉴클레오티드 및 대립유전자를 선택적으로 증폭하기 위한 방법

Country Status (8)

Country Link
US (1) US20240301481A1 (https=)
EP (1) EP4288557A4 (https=)
JP (1) JP2024505119A (https=)
KR (1) KR20230141826A (https=)
CN (1) CN116888271A (https=)
AU (1) AU2022216246A1 (https=)
CA (1) CA3206960A1 (https=)
WO (1) WO2022169846A1 (https=)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2222510A1 (en) * 1995-06-07 1996-12-19 Gen-Probe Incorporated Template and primer based synthesis of enzymatically cleavable oligonucleotides
US5916777A (en) * 1995-06-07 1999-06-29 Gen-Probe Incorporated Enzymatic synthesis of oligonucleotides using 3'-ribonucleotide primers
CN1254548C (zh) * 2000-08-23 2006-05-03 宝生物工程株式会社 核酸扩增方法
WO2002064833A1 (en) * 2001-02-15 2002-08-22 Takara Bio Inc. Method of detecting nucleotide polymorphism
US10227641B2 (en) * 2008-04-30 2019-03-12 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
ES2384681T3 (es) * 2008-08-12 2012-07-10 F. Hoffmann-La Roche Ag Extensión de cebadores correctora
WO2011085075A2 (en) * 2010-01-07 2011-07-14 Gen9, Inc. Assembly of high fidelity polynucleotides
CA2863808C (en) * 2012-02-20 2020-07-21 Speedx Pty Ltd Methods and oligonucleotides for amplifying and/or detecting nucleic acids
UA116205C2 (uk) * 2012-04-09 2018-02-26 Енвіролоджикс Інк. Спосіб кількісного визначення послідовності нуклеїнової кислоти в зразку
WO2017142989A1 (en) * 2016-02-17 2017-08-24 Admera Health LLC Nucleic acid preparation and analysis

Also Published As

Publication number Publication date
EP4288557A4 (en) 2024-12-25
EP4288557A1 (en) 2023-12-13
CA3206960A1 (en) 2022-08-11
WO2022169846A1 (en) 2022-08-11
AU2022216246A1 (en) 2023-09-14
JP2024505119A (ja) 2024-02-02
US20240301481A1 (en) 2024-09-12
CN116888271A (zh) 2023-10-13

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Patent event date: 20230830

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Comment text: International Patent Application

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Patent event code: PA02012R01D

Patent event date: 20250120

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