CA3194954A1 - Crystalline forms of a compound for the targeted degradation of estrogen receptor - Google Patents

Crystalline forms of a compound for the targeted degradation of estrogen receptor

Info

Publication number
CA3194954A1
CA3194954A1 CA3194954A CA3194954A CA3194954A1 CA 3194954 A1 CA3194954 A1 CA 3194954A1 CA 3194954 A CA3194954 A CA 3194954A CA 3194954 A CA3194954 A CA 3194954A CA 3194954 A1 CA3194954 A1 CA 3194954A1
Authority
CA
Canada
Prior art keywords
polymorph
compound
radiation
disease
disorder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3194954A
Other languages
English (en)
French (fr)
Inventor
Katharine Victoria BOULTON
Chungpin Herman CHEN
III Royal J. HASKELL
Hayley REECE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arvinas Operations Inc
Original Assignee
Arvinas Operations Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arvinas Operations Inc filed Critical Arvinas Operations Inc
Publication of CA3194954A1 publication Critical patent/CA3194954A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA3194954A 2020-09-14 2021-09-13 Crystalline forms of a compound for the targeted degradation of estrogen receptor Pending CA3194954A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063078225P 2020-09-14 2020-09-14
US63/078,225 2020-09-14
PCT/US2021/050046 WO2022056368A1 (en) 2020-09-14 2021-09-13 Crystalline forms of a compound for the targeted degradation of estrogen receptor

Publications (1)

Publication Number Publication Date
CA3194954A1 true CA3194954A1 (en) 2022-03-17

Family

ID=78080527

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3194954A Pending CA3194954A1 (en) 2020-09-14 2021-09-13 Crystalline forms of a compound for the targeted degradation of estrogen receptor

Country Status (20)

Country Link
US (2) US12162859B2 (enExample)
EP (1) EP4211128A1 (enExample)
JP (1) JP2023541434A (enExample)
KR (1) KR20230069144A (enExample)
CN (1) CN116390916A (enExample)
AR (1) AR123492A1 (enExample)
AU (1) AU2021342287A1 (enExample)
BR (1) BR112023004656A2 (enExample)
CA (1) CA3194954A1 (enExample)
CL (1) CL2023000712A1 (enExample)
CO (1) CO2023004435A2 (enExample)
CR (1) CR20230162A (enExample)
DO (1) DOP2023000052A (enExample)
EC (1) ECSP23027481A (enExample)
IL (1) IL301155A (enExample)
MX (1) MX2023002979A (enExample)
PE (1) PE20231555A1 (enExample)
RS (1) RS20230288A1 (enExample)
TW (1) TW202214236A (enExample)
WO (1) WO2022056368A1 (enExample)

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CN117229286A (zh) * 2022-06-14 2023-12-15 海创药业股份有限公司 一种芳香类化合物及其制备方法及在制备雌激素受体降解剂中的用途
EP4724045A1 (en) * 2023-06-12 2026-04-15 Arvinas Operations, Inc. Solid oral dosage forms of estrogen receptor degraders
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WO2026018182A1 (en) 2024-07-19 2026-01-22 Pfizer Inc. Process for preparing a cis-1,2-diaryltetralin derivative

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