AU2021342287A1 - Crystalline forms of a compound for the targeted degradation of estrogen receptor - Google Patents

Crystalline forms of a compound for the targeted degradation of estrogen receptor Download PDF

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Publication number
AU2021342287A1
AU2021342287A1 AU2021342287A AU2021342287A AU2021342287A1 AU 2021342287 A1 AU2021342287 A1 AU 2021342287A1 AU 2021342287 A AU2021342287 A AU 2021342287A AU 2021342287 A AU2021342287 A AU 2021342287A AU 2021342287 A1 AU2021342287 A1 AU 2021342287A1
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polymorph
compound
radiation
disease
disorder
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Inventor
Katharine Victoria BOULTON
Chungpin Herman CHEN
Royal J. HASKELL III
Hayley REECE
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Arvinas Operations Inc
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Arvinas Operations Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2021342287A 2020-09-14 2021-09-13 Crystalline forms of a compound for the targeted degradation of estrogen receptor Pending AU2021342287A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063078225P 2020-09-14 2020-09-14
US63/078,225 2020-09-14
PCT/US2021/050046 WO2022056368A1 (en) 2020-09-14 2021-09-13 Crystalline forms of a compound for the targeted degradation of estrogen receptor

Publications (1)

Publication Number Publication Date
AU2021342287A1 true AU2021342287A1 (en) 2023-04-13

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AU2021342287A Pending AU2021342287A1 (en) 2020-09-14 2021-09-13 Crystalline forms of a compound for the targeted degradation of estrogen receptor

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US (2) US12162859B2 (enExample)
EP (1) EP4211128A1 (enExample)
JP (1) JP2023541434A (enExample)
KR (1) KR20230069144A (enExample)
CN (1) CN116390916A (enExample)
AR (1) AR123492A1 (enExample)
AU (1) AU2021342287A1 (enExample)
BR (1) BR112023004656A2 (enExample)
CA (1) CA3194954A1 (enExample)
CL (1) CL2023000712A1 (enExample)
CO (1) CO2023004435A2 (enExample)
CR (1) CR20230162A (enExample)
DO (1) DOP2023000052A (enExample)
EC (1) ECSP23027481A (enExample)
IL (1) IL301155A (enExample)
MX (1) MX2023002979A (enExample)
PE (1) PE20231555A1 (enExample)
RS (1) RS20230288A1 (enExample)
TW (1) TW202214236A (enExample)
WO (1) WO2022056368A1 (enExample)

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WO2026018182A1 (en) 2024-07-19 2026-01-22 Pfizer Inc. Process for preparing a cis-1,2-diaryltetralin derivative

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